A5027605173- Head and Neck Surgical Oncology
- Tracheal and airway disorders
- Head and Neck Cancer Studies
- Hearing, Cochlea, Tinnitus, Genetics
- Lung Cancer Treatments and Mutations
- Hearing Loss and Rehabilitation
- Cervical Cancer and HPV Research
- Olfactory and Sensory Function Studies
- Vestibular and auditory disorders
- Sinusitis and nasal conditions
- Noise Effects and Management
- Dysphagia Assessment and Management
- Prostate Cancer Diagnosis and Treatment
- Advanced Chemical Sensor Technologies
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Nasal Surgery and Airway Studies
- Cancer Diagnosis and Treatment
- Esophageal and GI Pathology
- Cancer Immunotherapy and Biomarkers
- Allergic Rhinitis and Sensitization
- Prostate Cancer Treatment and Research
- Airway Management and Intubation Techniques
- Salivary Gland Tumors Diagnosis and Treatment
- Essential Oils and Antimicrobial Activity
Washington University in St. Louis
2016-2025
Office of Multidisciplinary Activities
2019-2024
St. Louis County Missouri
2016-2023
Laryngograph (United Kingdom)
2023
Weatherford College
2023
Stryker (United States)
2021
Cochlear (Australia)
2021
Barro Colorado Island
2021
University of Mississippi Medical Center
2020
White River Junction VA Medical Center
2019
Pembrolizumab improved survival in patients with recurrent or metastatic head and neck squamous-cell carcinoma (HNSCC). The aims of this study were to determine if pembrolizumab would be safe, result pathologic tumor response (pTR), lower the relapse rate resectable human papillomavirus (HPV)-unrelated HNSCC.Neoadjuvant (200 mg) was administered followed 2 3 weeks later by surgical ablation. Postoperative (chemo)radiation planned. Patients high-risk pathology (positive margins and/or...
Abstract BACKGROUND: Extracapsular spread (ECS) is commonly used to justify adjuvant chemotherapy in patients with head and neck cancer. The role of ECS as a prognosticator therapy determinant surgically resected, human papillomavirus‐related oropharyngeal squamous cell carcinoma (OPSCC), however, has never been determined. METHODS: Of 210 oropharynx prospective transoral laser microsurgery database, 152 who had p16‐positive primary OPSCC pathologically positive necks were eligible for the...
About 50% of patients with locally advanced head and neck squamous cell carcinoma (HNSCC) experience recurrences after definitive therapy. The presurgical administration anti-programmed death protein 1 (PD-1) immunotherapy results in substantial pathologic tumor responses (pTR) within the microenvironment (TME). However, mechanisms underlying dynamics antitumor T cells upon neoadjuvant PD-1 blockade remain unresolved, approaches to increase are lacking. In a phase 2 trial (NCT02296684), we...
Objectives/Hypothesis The goal of this study was to determine the incidence major complications following primary and revision functional endoscopic sinus surgery (FESS). In addition, aimed factors associated with occurrence including patient provider characteristics use image guidance system (IGS) technology. Study Design Retrospective cohort analysis California Florida all‐payer databases from 2005 2008. Methods rates surgical (skull base, orbital, hemorrhagic) after FESS were calculated,...
Radical prostatectomy, external beam radiotherapy and brachytherapy are accepted treatments for localized prostate cancer. However, it is unknown if survival differences exist among treatments. We analyzed the of patients treated with these modalities according to contemporary standards.A total 10,429 consecutive cancer radical prostatectomy (6,485), (2,264) or (1,680) were identified. Multivariable regression analyses used model disease (biopsy grade, clinical stage, specific antigen)...
Abstract Purpose: Vocal fold medialization laryngoplasty (ML) and laryngeal reinnervation (LR) as treatments for unilateral vocal paralysis (UVFP) were compared in a multicenter, prospective, randomized clinical trial. Methods: Previously untreated patients with UVFP to undergo either ML or LR. Voice results pretreatment at 6 12 months posttreatment using perceptual ratings by untrained listeners (RUL), blinded speech pathologist GRBAS scores, voice‐related quality of life (VRQOL) scores....
Noise-induced excitotoxicity is thought to depend on glutamate. However, the excitotoxic mechanisms are unknown, and necessity of glutamate for synapse loss or regeneration unclear. Despite absence glutamatergic transmission from cochlear inner hair cells in mice lacking vesicular transporter-3 (<i>Vglut3<sup>KO</sup></i>), at 9–11 weeks, approximately half number synapses found <i>Vglut3<sup>WT</sup></i> were maintained as postsynaptic AMPA receptors juxtaposed with presynaptic ribbons...
Abstract Purpose: Improved understanding of the molecular basis underlying oral squamous cell carcinoma (OSCC) aggressive growth has significant clinical implications. Herein, cross-species genomic comparison carcinogen-induced murine and human OSCCs with indolent or metastatic yielded results surprising translational relevance. Experimental Design: Murine OSCC lines were subjected to next-generation sequencing (NGS) define their mutational landscape, novel candidate cancer genes, assess for...
Abstract Although significant progress has been made in understanding outcomes following cochlear implantation, predicting performance remains a challenge. Duration of hearing loss, age at and electrode positioning within the cochlea together explain ~ 25% variability speech-perception scores quiet using implant (CI). Electrocochleography (ECochG) responses, prior to account for 47% variance same measures. No study date explored CI noise , more realistic measure natural listening. This aimed...
Importance There is a paucity of large-scale prospective studies evaluating the risk developing head and neck cancer (HNC) associated with smoking, drinking, dietary habits. Objective To determine association habits HNC. Design, Setting, Participants A nested cohort survival analysis Prostate, Lung, Colorectal, Ovarian (PLCO) Cancer Screening Trial participants was performed. were between 55 74 years age recruited at 10 centers across US from November 1993 to July 2001. who developed HNC...
Objective Identify the risk factors that predict 30‐day unplanned readmission in hospitalized otolaryngology patients. Study Design Retrospective cohort study. Setting Single academic hospital. Subjects and Methods All admissions for 1‐year period between January 1, 2011, December 31, at an hospital were reviewed. Univariate logistic regression multivariate regression, employing a backward elimination stepwise approach, performed to identify within 30 days of discharge from service. Results...
6012 Background: Pembrolizumab has efficacy in metastatic HNSCC. We hypothesized that treatment intensification surgically resectable HPV-negative, Stage III/IV HNSCC with neoadjuvant plus post-operative adjuvant (POA) pembrolizumab would be safe and reduce 1-year locoregional recurrence/distant metastases (LRR/DM) from 35% (historical: Cooper Bernier NEJM 2004) to 15%. Methods: Phase II trial where all eligible patients received 1 dose of (200 mg) prior surgery only those high-risk...
Objective To evaluate the impact of a Mindfulness Based Stress Reduction (MBSR) program in patients with chronic bothersome tinnitus on (1) severity symptoms and (2) functional connectivity neural attention networks. Study Design Open‐label interventional pilot study. Setting Outpatient academic medical center. Subjects A total 13 adult participants median age 55 years, suffering from tinnitus. Methods An 8‐week MBSR was conducted by trained instructor. The primary outcome measure difference...
Recent studies suggest that budesonide added to saline nasal lavage can be an effective treatment for patients with chronic rhinosinusitis (CRS).To evaluate the incremental effect of adding large-volume, low-pressure sinus irrigation.This double-blind, placebo-controlled, randomized clinical trial was conducted at a quaternary care academic medical center between January 1, 2016, and February 16, 2017. A total 80 adult CRS were enrolled; 74 completed baseline assessments; 61 remained in...
Data regarding outcomes after major head and neck ablation reconstruction in the growing geriatric population (specifically ≥80 years of age) are limited. Such information would be extremely valuable preoperative discussions with elderly patients about their surgical risks expected functional outcomes.To identify patient factors associated 30-day postoperative complications, 90-day mortality, decline; to explore whether an association exists between type reconstructive procedure outcome;...
Patients undergoing total laryngectomy are at high risk for hospital readmission. Hospital readmissions increasingly scrutinized because they used as a metric of quality care and subject to financial penalties.To determine the rate of, reasons for, factors that predict 30-day unplanned readmission patients laryngectomy.Retrospective cohort study single academic tertiary referral medical center. The population comprised 155 who underwent with or without flap closure between January 2007...
To explore the feasibility of ecological momentary assessments (EMAs) as a tool to more accurately assess level bother from tinnitus.Longitudinal observational study.Washington University Department Otolaryngology-Head and Neck Surgery faculty practice plan.Twenty participants with moderately severely bothersome tinnitus were enrolled. All owned smartphone device, all communications conducted via email, phone, text messaging. Participants received 4 EMAs per day for 2 weeks message final...
Objective To determine inpatient and outpatient tracheostomy complication rates 30‐day hospital readmission rates, to assess patient procedural risk factors associated with complications readmissions. Study Design Prospective cohort study. Methods Adult patients undergoing at a single academic performed by any service, for indication, were enrolled in this study over the course of 1 year. All had complete follow‐up after discharge rates. Logistic regression was used these events. Results One...