A5037137624- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Parkinson's Disease Mechanisms and Treatments
- Advanced Neuroimaging Techniques and Applications
- Neurological Disorders and Treatments
- Stroke Rehabilitation and Recovery
- Cell Adhesion Molecules Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Advanced Technologies in Various Fields
- Spatial Neglect and Hemispheric Dysfunction
- Advanced Technologies and Applied Computing
- Neurological disorders and treatments
- Advanced MRI Techniques and Applications
- Cholinesterase and Neurodegenerative Diseases
- Nuclear Receptors and Signaling
- Botulinum Toxin and Related Neurological Disorders
- Functional Brain Connectivity Studies
- Neurobiology of Language and Bilingualism
University of Pennsylvania
2020-2022
Penn Center for AIDS Research
2021-2022
California University of Pennsylvania
2020
Nanotherapeutics (United States)
2017
Abstract Introduction The ATN framework provides an in vivo diagnosis of Alzheimer's disease (AD) using cerebrospinal fluid (CSF) biomarkers pathologic amyloid plaques (A), tangles (T), and neurodegeneration (N). is rarely evaluated pathologically confirmed patients its poor sensitivity to suspected non‐Alzheimer's pathophysiologies (SNAP), including frontotemporal lobar degeneration (FTLD), leads misdiagnoses. We compared accuracy (ATN TAU ) CSF total tau (t‐tau) a modified strategy NfL...
Hyperphosphorylation and aggregation of tau protein is a critical factor in many neurodegenerative diseases. These diseases are increasing prevalence, there currently no cures. Previous work from our group others has shown that tyrosine kinase inhibitors (TKIs) can stimulate autophagy, decrease pathological proteins, improve symptoms models neurodegeneration. Here we examined the role pazopanib mouse express either human mutant P301L (TauP301L) or triple amyloid precursor (3x-AβPP). The...
Background: An understudied variant of Alzheimer’s disease (AD), the behavioral/dysexecutive AD (bvAD), is associated with progressive personality, behavior, and/or executive dysfunction and frontal atrophy. Objective: This study characterizes neuropsychological neuroanatomical features bvAD by comparing it to behavioral frontotemporal dementia (bvFTD), amnestic (aAD), subjects normal cognition. Methods: Subjects included 16 bvAD, 67 bvFTD, 18 aAD patients, 26 healthy controls....
Behavioral variant frontotemporal degeneration (bvFTD) is clinically characterized by progressive decline in social and executive domains. Previous work suggests that early lifestyle factors such as education occupational attainment may relate to structural integrity moderate the rate of cognitive bvFTD, but role other cognitively stimulating activities understudied. We sought investigate effect on cortical thickness (CT) bvFTD. bvFTD patients (n = 31) completed a baseline MRI scan,...
Background: Previous research finds a range of numbers impairments in Parkinsonian syndromes (PS), but has largely focused on how visuospatial impact deficits basic numerical processes (e.g., magnitude judgments, chunking). Differentiation between these functions and more complex often utilized everyday tasks may help elucidate neurocognitive neuroanatomic bases PS. Objective: To test correlates processing PS, we assessed number abilities, neuropsychological performance, cortical thickness...
ABSTRACT An understudied non-amnestic variant of Alzheimer’s disease (AD), behavioral AD (bvAD) is associated with progressive personality, behavior, or executive dysfunction and frontal atrophy. This study characterizes the neuropsychological neuroanatomical features bvAD by comparing it to frontotemporal dementia (bvFTD), amnestic (aAD), subjects normal cognition. Subjects included 16 bvAD, 67 bvFTD, 18 aAD patients, 26 healthy controls. Compared showed more significant visuospatial...
ABSTRACT Behavioral variant frontotemporal degeneration (bvFTD) is clinically characterized by progressive decline in social and executive domains. Previous work suggests that early lifestyle factors such as education occupational attainment may relate to structural integrity moderate the rate of cognitive bvFTD, but role other cognitively stimulating activities understudied. We sought investigate effect on cortical thickness (CT) bvFTD. bvFTD patients (n=31) completed a baseline MRI scan,...
Abstract Background Recent models propose that spread of Alzheimer's disease (AD) pathology may be mediated by white matter connectivity. AD clinical variants exhibit partially distinct patterns gray atrophy. However, it is less clear whether phenotypic differences extend to patients' connectomes. We hypothesized connectivity would differ between healthy controls, amnestic (aAD), and non‐amnestic (naAD), including behavioral variant (bvAD), logopenic‐variant primary progressive aphasia...