Jordan Massey
A5016424922- Immune cells in cancer
- Intracerebral and Subarachnoid Hemorrhage Research
- Homelessness and Social Issues
- Neuroinflammation and Neurodegeneration Mechanisms
- Epigenetics and DNA Methylation
Yale University
2019-2021
Background and Purpose— Enhancement of erythrophagocytosis by macrophages in a timely manner can limit the toxic effects erythrocyte metabolites promote brain recovery after intracerebral hemorrhage (ICH). In current study, we investigated therapeutic effect retinoid X receptor agonist, bexarotene, facilitating neurobehavioral 2 mouse models ICH. Methods— Bone marrow-derived fluorescently labeled erythrocytes were used to study vitro with phenotypic changes quantified gene expression. ICH...
RNA sequencing of cerebral hematoma myeloid cells reveals a two-stage functional and metabolic program associated with recovery.
Brain tissue-resident microglia and monocyte-derived macrophages (MDMs) are innate immune cells that contribute to the inflammatory response, phagocytosis of debris, tissue repair after injury. We have previously reported both MDMs transition from proinflammatory reparative phenotypes over days an intracerebral hemorrhage (ICH). However, their individual functional properties in brain remain largely unknown. Here we characterized differences between further elucidate distinct activation...