A5033773853- Acute Ischemic Stroke Management
- Cardiac, Anesthesia and Surgical Outcomes
- Traumatic Brain Injury and Neurovascular Disturbances
- Atrial Fibrillation Management and Outcomes
- Intensive Care Unit Cognitive Disorders
- Venous Thromboembolism Diagnosis and Management
- Anesthesia and Sedative Agents
- Antiplatelet Therapy and Cardiovascular Diseases
- Cerebrovascular and Carotid Artery Diseases
- Electrolyte and hormonal disorders
- Intracranial Aneurysms: Treatment and Complications
- Acute Kidney Injury Research
- Clinical Nutrition and Gastroenterology
- Poisoning and overdose treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Anesthesia and Neurotoxicity Research
- Nutrition and Health in Aging
- Cardiac Arrest and Resuscitation
- Pharmaceutical Practices and Patient Outcomes
- Migraine and Headache Studies
- COVID-19 and healthcare impacts
- Neurological Disorders and Treatments
- Coronary Interventions and Diagnostics
- Diabetes Management and Research
- Renal function and acid-base balance
The Ohio State University Wexner Medical Center
2018-2025
The Ohio State University
2020-2025
Institut de Virologie
2021
University of Kentucky HealthCare
2015-2021
May Institute
2020
Columbus Oncology and Hematology Associates
2019
Methodist University Hospital
2019
University of Tennessee Health Science Center
2019
UAB Medicine
2017
University of Alabama at Birmingham Hospital
2017
Intracerebral hemorrhage is the most serious type of stroke, leading to high rates severe disability and mortality. Hematoma expansion an independent predictor poor functional outcome a compelling target for intervention. For decades, randomized trials aimed at decreasing hematoma through single interventions have failed meet their primary outcomes statistically significant improvement in neurological outcomes. A wide range evidence suggests that ultra-early bundled care, with multiple...
Background: Since the approval of oral factor Xa inhibitors, there have been concerns regarding ability to neutralize their anticoagulant effects after intracranial hemorrhage (ICH). Multiple guidelines suggest using prothrombin complex concentrates (PCCs) in these patients on basis research that includes a limited number with ICH. Given this, we aimed evaluate safety and efficacy PCCs for inhibitor–related ICH large, multicenter cohort patients. Methods: This was multicenter, retrospective,...
SMEDIRA, N. G.; EVANS, B. H.; GRAIS, L. S.; COHEN, LO, B.; COOKE, M.; SCHECHTER, W. P.; FINK, C.; EPSTEIN-JAFFE, E.; MAY, LUCE, J. M. Author Information
Abstract Context The coronavirus disease 2019 (COVID-19) pandemic has created a need for remote blood glucose (BG) monitoring in the intensive care unit (ICU). Objective To evaluate feasibility and patient safety of hybrid strategy point-of-care (POC) BG plus continuous monitor (CGM) ICU. Design Retrospective analysis. Setting ICU an academic medical center. Patients with COVID-19 on IV insulin. Intervention After meeting initial validation criteria, CGM was used insulin titration POC...
<title>Abstract</title> <bold>Background and Objective:</bold> The determination of death by neurologic criteria (DNC) is completed a clinical examination alone if no confounding conditions render the unreliable. Currently, consensus guidelines on DNC state patient should be free any confounders prior to testing; however, how these are reviewed evaluated not specified. This project aimed investigate assessment medication during DNC.<bold>Methods:</bold> A 28-question survey was developed...
Background: Increasing evidence suggests that large-volume infusions of 0.9% sodium chloride (NaCl) for resuscitation are associated with hyperchloremic metabolic acidosis, renal vasoconstriction, and increased risk acute kidney injury (AKI). Patients neurological may require hypertonic NaCl therapeutic hypernatremia, treatment cerebral salt wasting, hyponatremia, or elevated intracranial pressure. Consequently, this exposure to result in an development AKI. Objective: The primary aim study...
Paroxysmal sympathetic hyperactivity ( PSH ) affects approximately 10% of survivors acquired brain injury and is associated with substantial morbidity. The most effective maintenance therapies include oral β‐blockers α‐2 antagonists. We report the use rectal propranolol for symptomatic control in a critically ill patient an altered gastrointestinal tract whom intake was contraindicated. A 15‐year‐old C aucasian male no past medical history admitted status post all‐terrain vehicle rollover...
Perturbations in resting energy expenditure (REE) among critically ill stroke patients are defined, and guidelines recommend weight-based dosing when indirect calorimetry (IC) is not feasible to estimate daily requirements. We aimed determine whether guideline-recommended provides adequate requirements compared with recommended IC target.IC data was collected on admitted a neurocritical care unit. low-weight-based (25 kcal/kg) high (30 the REE target. Subsequently, we analyzed effect of...
Dexmedetomidine is used in neurocritical care units (NCCUs) due to the light, dose-dependent sedation, and anxiolysis provided. It unknown how dose dexmedetomidine obese patients. The primary objective assess ability achieve goal Richmond Agitation Sedation Scale (RASS) measurements patients with a neurological injury who are solely on before after an institutional dosing change from actual body weight (ABW) adjusted (AdjBW).This study included admitted NCCU condition, required for at least...
Background Emergent neuroendovascular stenting presents challenges for the utilization of antiplatelet agents. Methods This was a multicenter, retrospective cohort patients who underwent emergent stenting. The primary endpoints were thrombotic and bleeding events in relation to timing administration, route choice intravenous (IV) agent study investigated practice variability utilization. Results Five-hundred seventy screened across 12 sites. Of those, 167 included data analysis. For...
Dexmedetomidine is a highly selective α2-adrenoreceptor agonist that produces dose-dependent sedation, anxiolysis, and analgesia without respiratory depression. Due to these ideal sedative properties, there has been increased interest in utilizing dexmedetomidine as first-line for critically ill patients requiring light sedation.To evaluate the ability achieve goal intensive care unit (ICU) sedation before after an institutional change of dosing from actual (ABW) adjusted (AdjBW) body weight...
Context. Modification of diet and exercise is known to be effective in treating diabetes obesity, but options for practical, interventions are few. Objective. To assess the effectiveness a gym-based fitness competition with financial incentives weight loss control adults type 2 diabetes. Design. Retrospective analysis outcomes quality improvement initiative care. Analysis was made from comparisons measurements participants before enrollment those subset enrolling who finished challenge....