A5011597797- Traumatic Brain Injury and Neurovascular Disturbances
- Atrial Fibrillation Management and Outcomes
- Acute Ischemic Stroke Management
- Cardiac, Anesthesia and Surgical Outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- Intracranial Aneurysms: Treatment and Complications
- Clinical Nutrition and Gastroenterology
- Venous Thromboembolism Diagnosis and Management
- Child Nutrition and Feeding Issues
- Cerebrovascular and Carotid Artery Diseases
- Intensive Care Unit Cognitive Disorders
- Intracerebral and Subarachnoid Hemorrhage Research
- Opioid Use Disorder Treatment
- Pharmacological Effects and Toxicity Studies
- Sepsis Diagnosis and Treatment
- Cardiac Arrest and Resuscitation
- Cerebrospinal fluid and hydrocephalus
- Neurosurgical Procedures and Complications
- Pregnancy and Medication Impact
- Poisoning and overdose treatments
- Peripheral Artery Disease Management
- Esophageal and GI Pathology
- Epilepsy research and treatment
- Enhanced Recovery After Surgery
- Vagus Nerve Stimulation Research
Medical University of South Carolina
2013-2024
Anna Needs Neuroblastoma Answers
2018
University of Florida
2007
T he rate of stroke among adults with atrial fibrilla- tion (AF) varies widely, ranging between 1% and 20% annually (mean 4.5% per year) depending on comorbidities a patient's history prior cerebrovascular events. 1 Stratification risk is important, because the major antithrombotic medications used to lower incidence AF-related bleeding.2][3] The advent several new agents offers alternatives warfarin may threshold for thromboembolic initiating therapy in patients AF.In this update American...
Background: Since the approval of oral factor Xa inhibitors, there have been concerns regarding ability to neutralize their anticoagulant effects after intracranial hemorrhage (ICH). Multiple guidelines suggest using prothrombin complex concentrates (PCCs) in these patients on basis research that includes a limited number with ICH. Given this, we aimed evaluate safety and efficacy PCCs for inhibitor–related ICH large, multicenter cohort patients. Methods: This was multicenter, retrospective,...
Despite advances in endovascular techniques, mechanical thrombectomy (MT) fails to achieve successful reperfusion approximately 20% of patients. This study aimed identify common etiologies and predictors failed a contemporary series.A prospectively maintained database MT patients between January 2013 August 2021 was interrogated. Failed defined as final modified Thrombolysis Cerebral Infarction score < 2b. Demographic data, procedural details, stroke etiology, anatomical data who underwent...
Methylnaltrexone and alvimopan are two new potentially useful agents in the management of opioid-induced bowel dysfunction prevention postoperative ileus. Both have promising prokinetic properties appear to be capable reversing effects opioids on delayed gastrointestinal transit. This article reviews currently available published literature provide an overview clinical trials insight for potential use these patients requiring opioid based analgesia. These compounds represent a class that may...
Background: Headache is a debilitating complication following an aneurysmal subarachnoid hemorrhage (aSAH). Despite its impact on morbidity and quality of life, limited evidence characterizes the effectiveness opioids. Objective: The aim this study was to evaluate opioid associated reduction in pain scores patients with aSAH-associated headache. Methods: This retrospective adult aSAH, Hunt Hess grades I – III, admitted neurosciences intensive care unit. Descriptive inferential statistics...
Study Objective. To determine the effects of mild‐to‐moderate induced hypothermia—a neuroprotectant and/or therapeutic strategy for management intracranial hypertension in neurologically injured patients—on pharmacokinetics aminoglycoside therapy. Design . Pharmacokinetic analysis. Setting Critical care unit at a university‐affiliated hospital. Patients Three patients, aged 22, 24, and 47 years, who received tobramycin had documented levels while undergoing hypothermia more than 24 hours...
Cefoxitin is a second-generation cephamycin antibiotic, which at concentrations ≥100 µg/mL known to modestly interfere, for up 2 hours post-infusion, with serum creatinine measurement via the traditional Jaffe-based assay. We report case of severe elevation while utilizing cefoxitin as component an antimicrobial regimen in critically ill patient Mycobacterium abscessus ventriculomeningitis. Our results, both analysis and spiking experiment, demonstrate interference despite utilization...
To determine if direct admission of status epilepticus (SE) patients to a comprehensive epilepsy center (CEC) is associated with improved outcome compared community hospital subsequent CEC transfer.
Clopidogrel hyperresponsiveness is a timely topic, with wide ranging reports of hemorrhagic complications, using various clopidogrel dosing strategies following neuroendovascular procedures. This study serves to investigate complications standard doses and timing these in relation the procedure.
Purpose: The objective of this study is to characterize opioid intensity in the intensive care unit (ICU) and its association with utilization across transitions. Methods: This a prospective cohort study. Medically ill ICU patients complete medication histories who survived discharge were included. Opioid was characterized based on IV morphine milligram equivalents (IV MME). Primary outcomes prescribing upon hospital discharge. Results: Opioids prescribed 34.1% 31.1% Within ≥50 mean MME/ICU...
Methylnaltrexone and alvimopan are two new potentially useful agents in the management of opioid-induced bowel dysfunction prevention postoperative ileus. Both have promising prokinetic properties appear to be capable reversing effects opioids on delayed gastrointestinal transit. This article reviews currently available published literature provide an overview clinical trials insight for potential use these patients requiring opioid based analgesia. These compounds represent a class that may...
Valproic acid (VPA) is a broad-spectrum anticonvulsant drug. Under normal conditions, this drug highly protein bound. However, in patients with hypoalbuminemia, the free fraction can increase substantially while total VPA levels remain therapeutic range. The neurologic activity and toxicity of are directly related to levels.Our in-house assay was validated using 20 patient samples obtained from reference laboratory (RL1). It further evaluated by parallel testing RL1 collected our patients....