A5091314623- Intracerebral and Subarachnoid Hemorrhage Research
- Acute Ischemic Stroke Management
- Neurosurgical Procedures and Complications
- Atrial Fibrillation Management and Outcomes
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Myasthenia Gravis and Thymoma
- Heavy Metal Exposure and Toxicity
- Pharmacological Effects and Toxicity Studies
- Peripheral Neuropathies and Disorders
- Total Knee Arthroplasty Outcomes
- Orthopaedic implants and arthroplasty
- Hemoglobinopathies and Related Disorders
- Cerebrovascular and Carotid Artery Diseases
- Takotsubo Cardiomyopathy and Associated Phenomena
- SARS-CoV-2 and COVID-19 Research
- Hereditary Neurological Disorders
- Sarcoidosis and Beryllium Toxicity Research
- Gestational Trophoblastic Disease Studies
- Healthcare Policy and Management
- S100 Proteins and Annexins
- Antiplatelet Therapy and Cardiovascular Diseases
- Cerebral Venous Sinus Thrombosis
- Inflammatory mediators and NSAID effects
- Occupational exposure and asthma
Munzur University
2024
Medical University of South Carolina
2012-2023
Boehringer Ingelheim (United States)
2020
Baylor College of Medicine
2014
University of North Carolina at Chapel Hill
2005
Scarborough General Hospital
1997-2005
University at Buffalo, State University of New York
1981
Background: Since the approval of oral factor Xa inhibitors, there have been concerns regarding ability to neutralize their anticoagulant effects after intracranial hemorrhage (ICH). Multiple guidelines suggest using prothrombin complex concentrates (PCCs) in these patients on basis research that includes a limited number with ICH. Given this, we aimed evaluate safety and efficacy PCCs for inhibitor–related ICH large, multicenter cohort patients. Methods: This was multicenter, retrospective,...
Patients undergoing total hip or knee replacement frequently receive blood transfusion. Homologous transfusion carries appreciable risks and should therefore be reduced to a minimum. We have investigated the use of preoperative oral iron supplements optimize haemoglobin concentration stores prior surgery. All patients attending preadmission clinic 4 weeks primary had measurement. If (Hb) was less than 12 g dL −1 they were given four week course ferrous sulphate. it greater equal randomized...
Abstract Background Protection against contemporary severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants requires sequence-adapted vaccines. Methods In this ongoing phase 2/3 trial, 12–17-year-olds (n = 108), 18–55-year-olds 313), and >55-year-olds 306) who previously received 3 original BNT162b2 30-µg doses, a fourth dose (second booster) of bivalent original/Omicron-BA.4/BA.5-adapted (BNT162b2-Omi.BA.4/BA.5). For comparisons with BNT162b2, participants were selected...
This case reviews the management of a 27-year-old pregnant female in myasthenic crisis. She presented to emergency department respiratory distress refractory standard therapy, necessitating airway and ventilatory support treatment with plasmapheresis. Myasthenic crisis setting pregnancy is rare presents unique challenges for physicians.
Abstract Although septic cavernous sinus thrombosis represents a rare cerebral vascular event, the morbidity and mortality can be profound. Diagnosis of this disease remains challenging, despite recent advances in imaging technology. We present 71‐year‐old man who presented with symptoms retro‐orbital pain, swelling history being treated for bacterial sinusitis. An initial non‐contrast head computed tomography showed dilated, hyperdense appearance his left superior ophthalmic vein,...
An association between Guillain-Barre syndrome and its variants (GBS/V) vaccines has led to hesitancy toward vaccination. COVID-19 could theoretically provoke GBS/V via immune activation. We analyzed reports of after vaccination in the vaccine adverse event reporting system (VAERS).The VAERS database is a surveillance used report events USA, open for consumers physicians access. It was queried following Reports were reviewed by four neurologists. Modified diagnostic criteria classify into...
To determine if direct admission of status epilepticus (SE) patients to a comprehensive epilepsy center (CEC) is associated with improved outcome compared community hospital subsequent CEC transfer.
Abstract Background Endogenous apoliloprotein E mediates neuroinflammatory responses and recovery after brain injury. Exogenously administered apolipoprotein E-mimetic peptides can effectively penetrate the down-regulate acute inflammation. CN-105 is a novel pentapeptide with excellent preclinical evidence as an intracerebral hemorrhage (ICH) therapeutic. The C N-105 in participants A cute supra T entorial intra erebral H emorrhage (CATCH) trial first-in-disease-state, multi-center,...
Rats made tolerant to endotoxin are partially protected from the histologic and functional injury that usually accompanies intramuscular administration of glycerol. Glycerol nephrotoxicity appears correlate with reductions in renal blood flow cardiac output which follow injection. Studies were undertaken determine if tolerance would alter these hemodynamic abnormalities. A radiolabelled microsphere technique was employed measure regional flow. Endotoxin-tolerant rats had higher outputs flows...