A5082783439- Anesthesia and Sedative Agents
- Atrial Fibrillation Management and Outcomes
- Intensive Care Unit Cognitive Disorders
- Epilepsy research and treatment
- Venous Thromboembolism Diagnosis and Management
- Intracerebral and Subarachnoid Hemorrhage Research
- COVID-19 Clinical Research Studies
- Pharmacological Effects and Toxicity Studies
- Antiplatelet Therapy and Cardiovascular Diseases
- Acute Ischemic Stroke Management
- Neuroscience and Neuropharmacology Research
- COVID-19 Impact on Reproduction
- Sepsis Diagnosis and Treatment
- Electrolyte and hormonal disorders
- Long-Term Effects of COVID-19
- Respiratory Support and Mechanisms
- Neurological and metabolic disorders
- Renin-Angiotensin System Studies
- Receptor Mechanisms and Signaling
- Thermal Regulation in Medicine
- Cerebral Venous Sinus Thrombosis
- COVID-19 and healthcare impacts
- Inflammatory mediators and NSAID effects
- Eicosanoids and Hypertension Pharmacology
- Blood Coagulation and Thrombosis Mechanisms
Yale New Haven Hospital
2015-2024
Sturdy Memorial Hospital
2024
Yale New Haven Health System
2019-2023
Arcadia
2022
Inova Fairfax Hospital
2020
University of Illinois Chicago
2020
Albert Einstein College of Medicine
1988-2020
University of New Haven
2017
Yale University
2017
UF Health Shands Hospital
2017
Abstract Pathologic immune hyperactivation is emerging as a key feature of critical illness in COVID-19, but the mechanisms involved remain poorly understood. We carried out proteomic profiling plasma from cross-sectional and longitudinal cohorts hospitalized patients with COVID-19 analyzed clinical data our health system database more than 3300 patients. Using machine learning algorithm, we identified prominent signature neutrophil activation, including resistin, lipocalin-2, hepatocyte...
Abstract Thrombotic complications occur at high rates in hospitalized patients with COVID‐19, yet the impact of intensive antithrombotic therapy on mortality is uncertain. We examined in‐hospital intermediate‐ compared to prophylactic‐dose anticoagulation, and separately aspirin no antiplatelet therapy, a large, retrospective study 2785 adult COVID‐19 patients. In this analysis, we established two separate, nested cohorts (a) who received or anticoagulation (“anticoagulation cohort”, N =...
Background: Since the approval of oral factor Xa inhibitors, there have been concerns regarding ability to neutralize their anticoagulant effects after intracranial hemorrhage (ICH). Multiple guidelines suggest using prothrombin complex concentrates (PCCs) in these patients on basis research that includes a limited number with ICH. Given this, we aimed evaluate safety and efficacy PCCs for inhibitor–related ICH large, multicenter cohort patients. Methods: This was multicenter, retrospective,...
Abstract Pathologic immune hyperactivation is emerging as a key feature of critical illness in COVID-19, but the mechanisms involved remain poorly understood. We carried out proteomic profiling plasma from cross-sectional and longitudinal cohorts hospitalized patients with COVID-19 analyzed clinical data our health system database over 3,300 patients. Using machine learning algorithm, we identified prominent signature neutrophil activation, including resistin, lipocalin-2, HGF, IL-8, G-CSF,...
Evidence‐based management of analgesia and sedation in COVID‐19‐associated acute respiratory distress syndrome remains limited. Non‐guideline recommended analgesic sedative medication regimens deeper targets have been employed for patients with COVID‐19 due to exaggerated requirements extended durations mechanical ventilation. This, coupled a desire minimize nurse entry into patient rooms, marked obesity, altered end‐organ function, evolving shortages, presents numerous short‐ long‐term...
Thrombotic complications occur at high rates in hospitalized patients with COVID-19, yet the impact of intensive antithrombotic therapy on mortality is uncertain. How does in-hospital compare intermediate- versus prophylactic-dose anticoagulation, and separately aspirin no antiplatelet therapy, treatment COVID-19? Using data from 2785 adult COVID-19 patients, we established two separate, nested cohorts (1) who received or anticoagulation ("anticoagulation cohort", N = 1624), (2) were not...
Labour mobility has been extensively studied in China and the European Union (EU). However, there very little attempt to compare internal migration EU China. This article provides an account of initial exploratory quantitative comparison Chinese migration. The first makes case for comparing context growing literature on international comparisons Problems data definition are then explored, a review undertaken identify which determinants could be used as basis comparative study. Mobility...
Abstract Introduction In response to the coronavirus disease 2019 (COVID‐19) pandemic, health care institutions have faced challenges necessitating operational agility facilitate provision of optimal patient care. This research was performed elucidate how pharmacy departments adapted their staffing models, and impact on frontline staff satisfaction. Methods Critical pharmacists in American College Clinical Pharmacy (ACCP) Society Health‐System Pharmacists list‐serves were electronically...
The possible role of histamine or adenosine in intestinal blood flow autoregulation 1-mo-old swine was examined by obtaining pressure-flow relationships before and during H1- adenosine-receptor blockade two groups fasting animals under anesthesia with pentobarbital sodium (30 mg/kg). Changes abdominal thoracic aortic pressures superior mesenteric left renal arterial flows were recorded controlled compression above the celiac artery. After control obtained, a test dose agonist (0.1 microgram...
From the Department of Pharmacy Services, Yale-New Haven Hospital, New Haven, CT. Received for publication January 20, 2016; accepted 21, 2016. Reprints: David P. Reardon, PharmD, BCPS, 20 York Street, PS-LL, CT 06510. E-mail: [email protected]