A5101748979- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Heart Failure Treatment and Management
- Acute Kidney Injury Research
- Blood Pressure and Hypertension Studies
- COVID-19 Clinical Research Studies
- Medication Adherence and Compliance
- Pharmaceutical Practices and Patient Outcomes
- COVID-19 and healthcare impacts
- Chronic Kidney Disease and Diabetes
- Animal Virus Infections Studies
- Potassium and Related Disorders
- Sepsis Diagnosis and Treatment
- Renal function and acid-base balance
- Cardiac pacing and defibrillation studies
- Medical Imaging and Pathology Studies
- Enzyme Structure and Function
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Cardiac, Anesthesia and Surgical Outcomes
- Influenza Virus Research Studies
- Seismic Waves and Analysis
- COVID-19 diagnosis using AI
- Electrolyte and hormonal disorders
- Animal Disease Management and Epidemiology
- Medical Imaging Techniques and Applications
Taisei (Japan)
2013-2025
Yale University
2019-2024
Yokohama City University Medical Center
2024
Lion Corporation (Japan)
2021-2024
National Institute of Animal Health
2007-2024
Yokohama City University
2009-2024
National Agriculture and Food Research Organization
2020-2024
University of Alabama at Birmingham
2024
University Hospital Regensburg
2023
Creative Commons
2023
Abstract Pathologic immune hyperactivation is emerging as a key feature of critical illness in COVID-19, but the mechanisms involved remain poorly understood. We carried out proteomic profiling plasma from cross-sectional and longitudinal cohorts hospitalized patients with COVID-19 analyzed clinical data our health system database more than 3300 patients. Using machine learning algorithm, we identified prominent signature neutrophil activation, including resistin, lipocalin-2, hepatocyte...
<h3>Importance</h3> Acute kidney injury (AKI) occurs in up to half of patients hospitalized with coronavirus disease 2019 (COVID-19). The longitudinal effects COVID-19–associated AKI on function remain unknown. <h3>Objective</h3> To compare the rate change estimated glomerular filtration (eGFR) after hospital discharge between and without COVID-19 who experienced in-hospital AKI. <h3>Design, Setting, Participants</h3> A retrospective cohort study was conducted at 5 hospitals Connecticut...
Abstract Objective To determine whether electronic health record alerts for acute kidney injury would improve patient outcomes of mortality, dialysis, and progression injury. Design Double blinded, multicenter, parallel, randomized controlled trial. Setting Six hospitals (four teaching two non-teaching) in the Yale New Haven Health System Connecticut Rhode Island, US, ranging from small community to large tertiary care centers. Participants 6030 adult inpatients with injury, as defined by...
The use of guideline-directed medical therapy (GDMT) is underprescribed in patients with heart failure reduced ejection fraction (HFrEF). This study sought to examine whether targeted and tailored electronic health record (EHR) alerts recommending GDMT eligible HFrEF improves use. PROMPT-HF (PRagmatic trial Of Messaging Providers about Treatment Heart Failure) was a pragmatic, EHR-based, cluster-randomized comparative effectiveness trial. A total 100 providers caring for were randomized...
Importance COVID-19 infection is associated with a high incidence of acute kidney injury (AKI). Although rapid function decline has been reported in the first few months after COVID-19−associated AKI (COVID-AKI), longer-term association COVID-AKI remains unknown. Objective To assess long-term outcomes patients who had AKI. Design, Setting, and Participants This was retrospective longitudinal multicenter cohort study conducted large hospital system using electronic health records data on...
Heart failure is a major cause of morbidity and mortality worldwide. The use risk scores has the potential to improve targeted interventions by clinicians that patient outcomes, but this hypothesis not been tested in randomized trial.To evaluate whether prognostic information heart translates into improved decisions about initiation intensity treatment, more appropriate end-of-life care, subsequent reduction rates hospitalization or death.This was pragmatic, multicenter, electronic health...
Patients hospitalized for acute heart failure (AHF) continue to be discharged on an inadequate number of guideline-directed medical therapies (GDMT) despite evidence that inpatient initiation is beneficial. This study aimed examine whether a tailored electronic health record (EHR) alert increased rates GDMT prescription at discharge in eligible patients AHF.Pragmatic trial messaging providers about treatment (PROMPT-AHF) was pragmatic, multicenter, EHR-based, and randomized clinical trial....
Abstract Poly(ε‐caprolactone) (PCL) with a pendent coumarin group was prepared by solution polycondensation from 7‐(3,5‐dicarboxyphenyl) carbonylmethoxycoumarin dichloride and α, ω‐dihydroxy terminated poly(ε‐caprolactone) molecular weights of 1250, 3000, 10,000 g/mol. These photosensitive polymers underwent rapid reversible photocrosslinking upon exposure to irradiation alternating wavelengths (>280/254 nm) without photoinitiator. The thermal mechanical properties the photocrosslinked...
Background Acute kidney injury (AKI) is an adverse event that carries significant morbidity. Given interventions after AKI occurrence have poor performance, there substantial interest in prediction of prior to its diagnosis. However, integration real-time prognostic modeling into the electronic health record (EHR) has been challenging, as complex models increase risk error and complicate deployment. Our goal this study was create implementable predictive model accurately predict hospitalized...
Background In patients receiving immune checkpoint inhibitor (ICI) therapy, acute kidney injury (AKI) is common, and can occur either from unrelated to ICI use or activation resulting in interstitial nephritis (AIN). this study, we test the hypothesis that occurrence of AIN indicates a favorable treatment response therapy therefore among who develop AKI while on those with will demonstrate greater survival compared others AKI. Methods observational cohort included participants initiated...
Abstract Acute kidney injury is common among hospitalized individuals, particularly those exposed to certain medications, and associated with substantial morbidity mortality. In a pragmatic, open-label, National Institutes of Health-funded, parallel group randomized controlled trial (clinicaltrials.gov NCT02771977), we investigate whether an automated clinical decision support system affects discontinuation rates potentially nephrotoxic medications improves outcomes in patients AKI....
Acute kidney injury (AKI) is a common complication during hospitalization and associated with adverse outcomes.
Lipid-lowering therapy (LLT) is underutilized for very high-risk atherosclerotic cardiovascular disease. PROMPT-LIPID (PRagmatic Trial of Messaging to Providers about Treatment HyperLIPIDemia) sought determine whether electronic health record (EHR) alerts improve 90-day LLT intensification in patients with
An E3 ubiquitin ligase inhibits the development of inflammatory T cells involved in autoimmune diseases.
Timely prediction of AKI in children can allow for targeted interventions, but the wealth data electronic health record poses unique modeling challenges.We retrospectively reviewed medical records all younger than 18 years old who had at least two creatinine values measured during a hospital admission from January 2014 through 2018. We divided study population into derivation, and internal external validation cohorts, used five feature selection techniques to select 10 720 potentially...
Abstract Pathologic immune hyperactivation is emerging as a key feature of critical illness in COVID-19, but the mechanisms involved remain poorly understood. We carried out proteomic profiling plasma from cross-sectional and longitudinal cohorts hospitalized patients with COVID-19 analyzed clinical data our health system database over 3,300 patients. Using machine learning algorithm, we identified prominent signature neutrophil activation, including resistin, lipocalin-2, HGF, IL-8, G-CSF,...
Digital health tools may improve quality of life (QoL) in patients with heart failure (HF) by promoting self-care, knowledge, and engagement.
We examined feathers of domestic ducks and geese inoculated with 2 different avian influenza virus (H5N1) genotypes. Together isolation from the skin, detection viral antigens ultrastructural observation virions in feather epidermis raise possibility as sources infection.
Signal transducer and activator of transcription 3 (STAT3), which mediates biological actions in many physiological processes, is activated by cytokines growth factors via specific tyrosine or serine phosphorylation, dimerization nuclear translocation. A recent study has demonstrated, using antibody to acetylated lysine, a STAT3 mutant with Lys-685-to-Arg substitution, that at Lys-685 histone acetyltransferase p300, acetylation critical for activation. In the present study, we created an...