A5013457303- Heart Failure Treatment and Management
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Medication Adherence and Compliance
- Chronic Lymphocytic Leukemia Research
- Cancer Genomics and Diagnostics
- Pregnancy and preeclampsia studies
- Cardiac pacing and defibrillation studies
- Lymphoma Diagnosis and Treatment
- Birth, Development, and Health
- Epigenetics and DNA Methylation
- Mobile Health and mHealth Applications
- Animal Genetics and Reproduction
- Click Chemistry and Applications
- Cardiovascular Effects of Exercise
- Renal and related cancers
- Cutaneous Melanoma Detection and Management
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Immunodeficiency and Autoimmune Disorders
- Phagocytosis and Immune Regulation
- Digital Mental Health Interventions
- CAR-T cell therapy research
- Systemic Sclerosis and Related Diseases
- Ferroptosis and cancer prognosis
- Reproductive Biology and Fertility
University of Florida
2023-2025
University of Rochester Medical Center
2020-2025
Yale University
2021-2024
University of Rochester
2023
Fetal development in an adverse utero environment significantly increases the risk of developing metabolic diseases later life, including dyslipidemia, non-alcoholic fatty liver and diabetes. The aim this study was to determine whether improving fetal growth with a placental nanoparticle gene therapy would ameliorate restriction (FGR)-associated dysregulation hepatic lipid glucose metabolism-related signaling pathways. Using guinea pig maternal nutrient (MNR) model insufficiency FGR,...
Fetal development in an adverse utero environment significantly increases the risk of hypertension and cardiovascular disease. The kidneys play a pivotal role regulation blood pressure function, perturbations kidney structure molecular profile are often demonstrated offspring born fetal growth restricted (FGR). aim this study was to determine whether improving with placental nanoparticle gene therapy would ameliorate FGR-associated dysregulation development. Using guinea pig maternal...
Abstract At over 200 years, the maximum lifespan of bowhead whale exceeds that all other mammals. The is also second-largest animal on Earth, reaching 80,000 kg 1 . Despite its very large number cells and long lifespan, not highly cancer-prone, an incongruity termed Peto’s Paradox 2 This phenomenon has been explained by evolution additional tumor suppressor genes in larger animals, supported research elephants demonstrating expansion p53 gene 3–5 Here we show fibroblasts undergo oncogenic...
Digital health tools may improve quality of life (QoL) in patients with heart failure (HF) by promoting self-care, knowledge, and engagement.
Abstract Background Self‐care and patient engagement are important elements of heart failure (HF) care, endorsed in the guidelines. Digital health tools may improve quality life (QOL) HF patients by promoting knowledge, engagement. This manuscript describes rationale challenges design implementation a pragmatic randomized controlled trial to evaluate efficacy three digital technologies improving QOL for with HF. Hypothesis We hypothesize that interventions will through early detection...
Metastatic melanoma portends a poor prognosis and patients may present with multiple, simultaneous tumors. Despite recent advances in systemic immunotherapy, majority of fail to respond, or exhibit lesion-specific responses wherein some metastases respond as others progress within the same patient. While intertumoral heterogeneity has been clinically associated these mixed therapeutic responses, no clear mechanism identified, largely due scarcity preclinical models. We developed novel murine...
<title>Abstract</title> Background The modified Rodnan skin score (mRSS), used to measure dermal thickness in patients with systemic sclerosis (SSc), is agnostic inflammation and vasculopathy. Previously, we demonstrated the potential of neural network-based digital pathology applied stained biopsies from SSc as a quantitative outcome. We leveraged deep learning histologic analyses clinical trial decipher features ‘seen’ by artificial intelligence (AI). Methods Adults diffuse cutaneous...
ABSTRACT Fetal development in an adverse utero environment significantly increases the risk of developing metabolic diseases later life, including dyslipidemia, non-alcoholic fatty liver and diabetes. The aim this study was to determine whether improving fetal growth with a placental nanoparticle gene therapy would ameliorate restriction (FGR)-associated dysregulation hepatic lipid glucose metabolism-related signaling pathways. Using guinea pig maternal nutrient (MNR) model insufficiency...
Abstract Background: Resistance to BRAF V600E inhibitors (dabrafenib) and MEK (trametinib) occurs in 6-8 months the majority of melanoma patients with target mutation. For this reason, combination targeted therapy (TT) offers reliable but often non-durable responses. A translatable model exhibiting de novo resistance TT response checkpoint inhibition (ICB) may offer an avenue for exploring mechanisms resistance, responses combined TT/ICB, modes treatment salvage. Methods: C57/BL6J mice...
Abstract Synchronous metastatic melanoma, clinically defined as multiple lesions diagnosed within 6 months, has a poor prognosis. Despite recent advances in systemic immunotherapy, majority of patients fail to respond or exhibit lesion-specific responses. While intertumoral heterogeneity been associated with therapeutic responses, no clear mechanism identified, largely due the scarcity preclinical models. We developed novel murine synchronous melanoma model that recapitulates clinical...
Abstract PD-1 (programmed cell death protein-1) blockade, an immunotherapy that re-stimulates antitumor CD8 T response, has revolutionized the treatment of metastatic melanoma. However, majority melanoma patients eventually acquire therapy resistance. The emergence resistant metastases likely results from de novo somatic mutations secondary to inherent tumor genetic instability. We hypothesize intertumoral differences introduce immunosuppressive mechanisms, such as inducing myeloid-derived...
<h3>Background</h3> Despite recent advancements in systemic therapy, only a minority of metastatic patients develop meaningful clinical responses to immune checkpoint inhibitors. Inherent genetic instability melanoma generates genomically and microenvironmentally distinct metastases. These different tumor microenvironments (TMEs) contain numerous T cell suppression mechanisms, such as upregulation the PD-1/PD-L1 exhaustion pathway. However, synchronous metastases share one host system,...
ABSTRACT Heart failure is a complex syndrome that contributes significantly to mortality and morbidity in the Unites States. Self-management an ACC/AHA-recommended management tool for chronic conditions, however, those with congestive heart have historically poor compliance, low health literacy, comorbidities lead reduced adherence therapies lifestyle modifications. Digital technologies potential enhance care improve self-management. This manuscript describes rationale challenges of design...