A5007400297- MicroRNA in disease regulation
- Circular RNAs in diseases
- Bone Metabolism and Diseases
- Cancer-related molecular mechanisms research
- Invertebrate Immune Response Mechanisms
- Mosquito-borne diseases and control
- Insect symbiosis and bacterial influences
- Osteoarthritis Treatment and Mechanisms
- Cancer-related Molecular Pathways
- Epigenetics and DNA Methylation
- Animal Genetics and Reproduction
University of Sheffield
2025
Newcastle University
2020-2025
University of East Anglia
2023
University of Liverpool
2023
First Hospital of Shanxi Medical University
2023
Shanxi Medical University
2023
Abstract At over 200 years, the maximum lifespan of bowhead whale exceeds that all other mammals. The is also second-largest animal on Earth, reaching 80,000 kg 1 . Despite its very large number cells and long lifespan, not highly cancer-prone, an incongruity termed Peto’s Paradox 2 This phenomenon has been explained by evolution additional tumor suppressor genes in larger animals, supported research elephants demonstrating expansion p53 gene 3–5 Here we show fibroblasts undergo oncogenic...
Abstract A wide range of specific microRNAs have been shown to either positive or negative effects on osteoblast differentiation and function, with consequent changes in postnatal bone mass. number targets identified. We previously used CrispR-Cas9 make a miR-455 null mouse, characterizing behavioral phenotype age. The current study identifies phenotype, starting younger animals. At 3 weeks age, the mice (both male female) display increased length both long bones vertebrae and, while this...
Macrophages are responsible for diverse and fundamental functions in vertebrates. Drosophila blood cells (haemocytes) dominated by bearing a striking homology to vertebrate macrophages (plasmatocytes). The importance of haemocytes has been demonstrated previously, with immune developmental phenotypes observed upon haemocyte ablation. Here we show that can increase Hml-positive cell numbers using constitutively-active form ras ablate the pro-apoptotic transgene bax. However, adults, compared...
MicroRNAs (miRNAs) modulate the expression of other RNA molecules. One miRNA can target many transcripts, allowing each to play key roles in biological pathways. Defects bone homeostasis result common age-related diseases including osteoporosis. Serum levels miR-324-3p positively correlate with several features maintenance. In contrast here, using vivo micro-computed tomography and histology, global miR-324-null mice demonstrated increased mineral density both trabecular cortical thickness,...
MicroRNAs are non-coding RNAs that act to downregulate the expression of target genes by translational repression and degradation messenger RNA molecules. Individual microRNAs have ability specifically a wide array gene transcripts, therefore allowing each microRNA play key roles in multiple biological pathways. miR-324 is predicted thousands transcripts expressed far more highly brain than any other tissue, suggesting it may role one or neurological Here we present data from first global...
Macrophages are responsible for diverse and fundamental functions in vertebrates. Fruit flies harbour an innate immune system of which the most populous blood cell (haemocyte) type bears striking homology to vertebrate macrophage. The importance these cells has been demonstrated previously, where developmental phenotypes have observed upon haemocyte ablation using pro-apoptotic transgenes driven by Hml promoter. Here we show that, as well ablating Hml-positive vivo transgene bax, can also...
Abstract microRNAs (miRNAs) are non-coding RNAs which modulate the expression of other RNA molecules. One miRNA can target many transcripts, allowing each to play key roles in biological pathways. miR-324 is a previously implicated bone and cartilage maintenance, defects result common age-related diseases, such as osteoporosis or osteoarthritis (OA). In global miR-324-null mice damage was increased both surgically ageing-induced OA, despite minimal changes transcriptome, with few predicted...
Abstract microRNAs (miRNAs) modulate the expression of other RNA molecules. One miRNA can target many transcripts, allowing each to play key roles in biological pathways. miR-324 is implicated bone and cartilage maintenance, defects which result common age-related diseases osteoporosis osteoarthritis. Here, global miR-324-null mice damage was increased both surgically ageing-induced osteoarthritis, despite minimal changes transcriptome. However, vivo micro-computed tomography histology...