Luca Masotti
A5032594788- Acute Ischemic Stroke Management
- Venous Thromboembolism Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurosurgical Procedures and Complications
- Acute Myocardial Infarction Research
- Cardiac Arrhythmias and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Cardiac Imaging and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
- Case Reports on Hematomas
- Lipoproteins and Cardiovascular Health
- Heart Failure Treatment and Management
- Ultrasound in Clinical Applications
- Diagnosis and Treatment of Venous Diseases
- Cardiac Arrest and Resuscitation
- Adipokines, Inflammation, and Metabolic Diseases
- Palliative Care and End-of-Life Issues
- Intensive Care Unit Cognitive Disorders
- Cardiovascular and Diving-Related Complications
- Cerebrovascular and Carotid Artery Diseases
- Sepsis Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
Ospedale San Giuseppe
2017-2024
Azienda Usl Toscana Centro
2022
Santa Maria Nuova Hospital
2014-2020
Ospedale Santa Maria
2014-2017
St. Anne's University Hospital Brno
2017
University Hospital of Alexandroupolis
2017
Democritus University of Thrace
2017
University General Hospital Attikon
2017
National and Kapodistrian University of Athens
2017
Azienda Sanitaria di Firenze
2016
Background and Purpose— The best time for administering anticoagulation therapy in acute cardioembolic stroke remains unclear. This prospective cohort study of patients with atrial fibrillation, evaluated (1) the risk recurrent ischemic event severe bleeding; (2) factors recurrence (3) risks bleeding associated anticoagulant its starting after stroke. Methods— primary outcome this multicenter was composite stroke, transient attack, symptomatic systemic embolism, cerebral major extracranial...
The European Society of Cardiology (ESC) has proposed an updated risk stratification model for death in patients with acute pulmonary embolism based on clinical scores (Pulmonary Embolism Severity Index (PESI) or simplified PESI (sPESI)), right ventricle dysfunction (RVD) and elevated serum troponin (2014 ESC model).We assessed the ability 2014 to predict 30-day after embolism. Consecutive symptomatic, confirmed included prospective cohorts were merged a collaborative database. Patients' was...
Background The optimal timing to administer non–vitamin K oral anticoagulants ( NOAC s) in patients with acute ischemic stroke and atrial fibrillation is unclear. This prospective observational multicenter study evaluated the rates of early recurrence major bleeding (within 90 days) their who received s for secondary prevention. Methods Results Recurrence was defined as composite stroke, transient attack, symptomatic systemic embolism, cerebral extracranial bleeding. For analysis, 1127 were...
Background and Purpose- Despite treatment with oral anticoagulants, patients nonvalvular atrial fibrillation (AF) may experience ischemic cerebrovascular events. The aims of this case-control study in AF were to identify the pathogenesis risk factors for events occurring during non-vitamin K antagonist anticoagulants (NOACs) therapy stroke prevention. Methods- Cases consecutive who had acute NOAC treatment. Controls did not have NOACs Results- Overall, 713 cases (641 strokes 72 transient...
In patients with atrial fibrillation who suffered an ischemic stroke while on treatment nonvitamin K antagonist oral anticoagulants, rates and determinants of recurrent events major bleedings remain uncertain.This prospective multicenter observational study aimed to estimate the bleeding their in follow-up consecutive acute cerebrovascular event anticoagulant treatment. Afterwards, we compared estimated risks between whom therapy was changed those continued original treatment.After a mean...
Hyperglycemia and inflammation are involved in the progression of spontaneous intracerebral hemorrhage (sICH)-induced brain injury, but their role predicting clinical outcome is not clear. We sought to determine whether elevation white blood cell count (WBC), C-reactive protein (CRP), glucose (BG) concentration at presentation prognosticate poor sICH patients.Between November 1, 2005 October 31, 2009, 210 patients admitted 2 intensive care units were prospectively consecutively evaluated...
Objective There is little evidence to guide treatment strategies for intracerebral hemorrhage on vitamin K antagonists (VKA‐ICH). Treatments utilized in clinical practice include fresh frozen plasma (FFP) and prothrombin complex concentrate (PCC). Our aim was compare case fatality with different reversal strategies. Methods We pooled individual ICH patient data from 16 stroke registries 9 countries (n = 10 282), of whom 1,797 (17%) were VKA. After excluding 250 patients international...
Early hematoma growth (EHG) occurs in about one third of patients with spontaneous intracerebral hemorrhage. The main aim this study was to investigate the potential plasma C-reactive protein (CRP) for predicting EHG after acute hemorrhage.Plasma CRP measured within 6 hours onset (median, 120 minutes) 399 primary or vitamin K antagonist-associated hemorrhage and without recent infection. Computed tomography brain scans were performed at baseline repeated 24 22 hours). outcome EHG, defined as...
Background In patients with acute ischemic stroke and atrial fibrillation, early anticoagulation prevents recurrence but the risk of hemorrhagic transformation ( HT ). The aims this study were to evaluate in consecutive fibrillation (1) incidence HT, (2) time initiation , (3) association recurrences, (4) clinical outcome at 90 days. Methods Results was diagnosed by a second brain computed tomographic scan performed 24 72 hours after onset. recurrences as well mortality or disability...
<h3>Objectives:</h3> We examined the C-reactive protein (CRP) response after spontaneous intracerebral hemorrhage (sICH) and its relationship to outcome. additionally characterized early brain localization of CRP. <h3>Methods:</h3> In this prospective, multicenter, international, collaborative, longitudinal study with cross-sectional immunohistochemical analysis tissue, 223 patients (M/F: 132/91) were recruited during 2010 calendar year. CRP was evaluated at admission (median 93 minutes from...
To the Editor-Defining prognosis of patients affected by coronavirus disease 2019 (COVID-19) due to severe acute respiratory syndrome 2 (SARS-CoV-2) infection is utmost importance for planning appropriate setting care and treatment.Therefore, we read with great interest article Ji colleagues that was recently published in Clinical Infectious Diseases [1].After exclusion presenting COVID-19 using data records 208 suffering from COVID-19, mean age ± standard deviation [SD] 44.0 16.3 years,...
COVID-19 infection causes respiratory pathology with severe interstitial pneumonia and extra-pulmonary complications; in particular, it may predispose to thromboembolic disease. The current guidelines recommend the use of thromboprophylaxis patients COVID-19, however, optimal heparin dosage treatment is not well-established. We conducted a multicentre, Italian, retrospective, observational study on admitted ordinary wards, describe clinical characteristic at admission, bleeding thrombotic...
Introduction: The efficacy and safety of statins for secondary prevention in patients who have experienced a cardioembolic stroke are not well-defined. However, previous observational data reported hyperlipidemia as risk factor both ischemic bleeding complications with AF stroke. Based on these premises, we conducted sub-analysis the RAF RAF-NOAC studies to evaluate acute AF. Materials methods: We combined patient from studies, prospective across Stroke Units Europe, United States, Asia...
The exact prevalence of mobile right heart thromboemboli (RHTh) in patients with pulmonary embolism (PE) is unknown, depending upon PE severity and the use early echocardiography. Similarly, mortality rate variable, though RHTh detection appears to substantially increase risk death PE. aim this study was assess different categories a wide series PE, analyse effect on in-hospital mortality. Among 1,716 enrolled Italian Pulmonary Embolism Registry, 1,275 (13.3% at high risk, 59.3% intermediate...