Luca Petraglia
A5015654900- Acute Ischemic Stroke Management
- Atrial Fibrillation Management and Outcomes
- Venous Thromboembolism Diagnosis and Management
- Heparin-Induced Thrombocytopenia and Thrombosis
- Platelet Disorders and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Lipoproteins and Cardiovascular Health
- Long-Term Effects of COVID-19
- Neurogenesis and neuroplasticity mechanisms
- Cardiac electrophysiology and arrhythmias
- Blood Coagulation and Thrombosis Mechanisms
- Cardiomyopathy and Myosin Studies
- Hemophilia Treatment and Research
- Traumatic Ocular and Foreign Body Injuries
- COVID-19 and healthcare impacts
- Climate Change and Health Impacts
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Arrhythmias and Treatments
- Nerve injury and regeneration
- Venomous Animal Envenomation and Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Advanced Neuroimaging Techniques and Applications
- Receptor Mechanisms and Signaling
- Transcranial Magnetic Stimulation Studies
- Cardiovascular Effects of Exercise
Policlinico Umberto I
2023-2024
Sapienza University of Rome
2020-2024
Federico II University Hospital
2017
We aimed to investigate the rate of hospital admissions for cerebrovascular events and revascularization treatments acute ischemic stroke in Italy during coronavirus disease 2019 (COVID-19) outbreak.
In patients with atrial fibrillation who suffered an ischemic stroke while on treatment nonvitamin K antagonist oral anticoagulants, rates and determinants of recurrent events major bleedings remain uncertain.This prospective multicenter observational study aimed to estimate the bleeding their in follow-up consecutive acute cerebrovascular event anticoagulant treatment. Afterwards, we compared estimated risks between whom therapy was changed those continued original treatment.After a mean...
Vaccine-induced thrombotic thrombocytopenia with cerebral venous thrombosis is a syndrome recently described in young adults within two weeks from the first dose of ChAdOx1 nCoV-19 vaccine. Here we report cases malignant middle artery (MCA) infarct and 9-10 days following vaccination. The arrived our facility around same time but different geographical areas, potentially excluding epidemiological links; meanwhile, no abnormality was found respective vaccine batches. Patient 1 57-year-old...
Introduction: The efficacy and safety of statins for secondary prevention in patients who have experienced a cardioembolic stroke are not well-defined. However, previous observational data reported hyperlipidemia as risk factor both ischemic bleeding complications with AF stroke. Based on these premises, we conducted sub-analysis the RAF RAF-NOAC studies to evaluate acute AF. Materials methods: We combined patient from studies, prospective across Stroke Units Europe, United States, Asia...
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Introduction: Ischaemic stroke patients with atrial fibrillation (AF) are at high risk of recurrence despite oral anticoagulation therapy. Patients cardiovascular comorbidities may take both antiplatelet and therapy (OAC/AP). Our study aims to evaluate the safety efficacy OAC/AP as secondary prevention in people AF ischaemic stroke. methods: We performed a post-hoc analysis pooled individual data from multicenter prospective cohort studies compared outcomes on DOAC/VKA alone (OAC cohort)....
Background: Ischemic stroke may trigger neuroplastic changes via proliferation, migration towards the lesion, and differentiation of neuroprogenitor cells into mature neurons. Repetitive Transcranial Magnetic Stimulation (rTMS) promote brain plasticity. This study aimed to assess rTMS’s effect on post-stroke endogenous neuroplasticity by dosing plasma miRs 17~92, Netrin-1, Sema3A, BDNF. Methods: In this case-controlled study, we randomized 19 ischemic patients within five days from symptoms...
Introduction: Patients with ischemic stroke (IS) and atrial fibrillation (AF) face a higher risk of recurrent vascular events. This study evaluates the impact atherosclerotic disease burden across different territories on events in patients recent AF within 90 days. Methods: We included IS from International RAF network prospective 90-day follow-up. Atherosclerotic was identified by at least one following: Symptomatic heart disease, symptomatic peripheral artery internal carotid stenosis...
Atrial fibrillation (AF) and congestive heart failure often coexist due to their shared risk factors leading potential worse outcome, particularly cerebrovascular events. The aims of this study were calculate the rates ischemic severe bleeding events in stroke patients having both AF reduced ejection fraction (rEF) (⩽40%), compared with but without rEF. We performed a retrospective analysis that drew data from prospective studies. primary outcome was composite either (stroke or systemic...
Abstract Background The efficacy and safety of statins for secondary prevention in patients who have experienced a cardioembolic stroke are not well-defined. However, previous observational data reported hyperlipidemia as risk factor both ischemic bleeding complications with AF stroke. Based on these premises, we conducted sub-analysis the RAF RAF-NOAC studies to evaluate acute AF. Methods We combined patient from studies, prospective across Stroke Units Europe, United States, Asia January...
Abstract Background. Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare syndrome of unclear aetiology occurring after DNA-based vaccinations against COVID-19. The aim this study was to investigate the DNA vaccine-encoded Sars-cov-2 soluble spike protein (SP). as potential trigger platelet activation in VITT. Methods. We studied three VITT patients and seven healthy controls (HCs) within 3 weeks from first dose ChAdOx1 nCoV-19, one non vaccinated HC. Serum levels SP...
Emergent reperfusion therapies have improved acute ischemic stroke prognosis, but many patients are still bound to bad clinical outcome, probably because of our incomplete knowledge its pathophysiology. Thanks mechanical thrombectomy, occluding material is available for histological analysis. Several studies investigated the possible relationship between thrombus composition and clinical, procedural, radiological variables stroke. The potential value analysis as a tool practice research not...
Abstract Vaccine induced thrombotic thrombocytopenia is a new syndrome recently described in young adults within two weeks from the first dose of ChAdOx1 nCoV-19 vaccine and characterized by cerebral venous thrombosis. We report cases malignant middle artery (MCA) infarct 10 days after vaccination with nCoV-19. Patient 1 was 57-year-old woman who underwent decompressive craniectomy despite successful mechanical thrombectomies. 2 55-year-old developed fatal bilateral MCA infarct. Both...
INTRODUCTION: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) was first reported in December 2019 an outbreak occurring Wuhan, China and has spread rapidly all over the word causing a global pandemic with approximately 129 million confirmed cases more than 2.8 deaths worldwide as of April 2nd, 2021. With increasing number people affected by this disease, it become early apparent that SARS-CoV-2 may also affect nervous system.EVIDENCE ACQUISITION: A great case reports, series...
# 266 Metoprolol induces cardiac beta-3 adrenergic receptor and Sphingosine 1 phosphate signals to prevent adverse Left-ventricle remodeling dysfunction after myocardial infarction {#article-title-2} Background: β-adrenergic (AR)-blockers are fore-front therapies against (MI)-induced other forms of heart failure (HF). Mechanisms accounting for these beneficial effects remain however only partially understood. In particular, due the difference in targeting great variability human HF-patients...
Background: Uncertainties remain about the role of common thrombophilia markers as determinants ischemic stroke (IS) risk. Polymorphism His1299Arg in FV gene, named R2 haplotype (FVHR2), has been poorly investigated. The aim present study was to assess prevalence and FVHR2 a cohort IS patients compared nonmatched group healthy individuals. Methods: We studied 156 consecutive survivors first ever 124 controls. All subjects were investigated for gene polymorphisms factor V (FV) Leiden,...