A5068303834- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Stroke Rehabilitation and Recovery
- Intracranial Aneurysms: Treatment and Complications
- Migraine and Headache Studies
- Cerebral Venous Sinus Thrombosis
- Venous Thromboembolism Diagnosis and Management
- COVID-19 and Mental Health
- Neurological and metabolic disorders
- Neurological Disease Mechanisms and Treatments
- Long-Term Effects of COVID-19
- Peripheral Artery Disease Management
- Neurological disorders and treatments
- CNS Lymphoma Diagnosis and Treatment
- Atrial Fibrillation Management and Outcomes
- Fetal and Pediatric Neurological Disorders
- Healthcare Systems and Practices
- Burn Injury Management and Outcomes
- Vascular Malformations and Hemangiomas
- Ophthalmology and Eye Disorders
- Vascular Malformations Diagnosis and Treatment
- Pituitary Gland Disorders and Treatments
- Genetic Neurodegenerative Diseases
Policlinico Umberto I
2023-2024
Sapienza University of Rome
2018-2024
University of Messina
2018-2024
University of Florence
2024
Ospedale Santa Maria Goretti
2023-2024
Weill Cornell Medicine
2018
Azienda Ospedaliera Sant'Andrea
2018
MIND Research Institute
2018
Cornell University
2018
The implementation of 12-lead ECG in the pre-participation screening young athletes is still controversial and number issues are largely debated, including prevalence spectrum abnormalities found individuals undergoing screening. We assessed a large, unselected population 32 652 subjects [26 050 (80%) males], prospectively examined 19 clinics associated to Italian Sports Medicine Federation. Most were amateur athletes, aged 8–78 years (median 17), predominantly students (68%), engaged soccer...
Abstract The ApoE4 allele is associated with increased risk of small vessel disease, which a cause vascular cognitive impairment. Here, we report that mice targeted replacement (TR) the ApoE gene human have reduced neocortical cerebral blood flow compared to ApoE3-TR mice, an effect due density rather than slowing microvascular red cell flow. Furthermore, homeostatic mechanisms matching local delivery brain activity are impaired in ApoE4-TR mice. In model hypoperfusion, these cerebrovascular...
Introduction: Previous reports and meta-analyses derived from small case series reported a mortality rate of up to 40% in patients with coronavirus disease 2019 associated cerebral venous thrombosis (COVID-CVT). We assessed the clinical characteristics outcomes an international cohort COVID-CVT. Patients methods: This was registry study consecutive COVID-CVT diagnosed between March 2020 2023. Data collected by International Cerebral Venous Thrombosis Consortium CVT 2017 2018 served as...
To identify new factors associated with hemorrhagic transformation (HT) despite early recanalization in patients acute ischemic stroke treated mechanical thrombectomy.We retrospectively included known onset of large vessel occlusion thrombectomy +/- intravenous thrombolysis. Non-contrast CT was performed at 24 12 h from endovascular procedure. We collected data on patient characteristics, risk factors, radiological and treatment features, severity admission discharge, carotid intima-media...
Acute ischemic stroke (AIS) due to basilar artery occlusion (BAO) represents 1-4% of all strokes. BAO results in strokes associated with a high risk poor functional outcome and, 86-95% the untreated cases, it death because vital cerebral structures involved. Diagnosis can be delayed variability presenting symptoms, and acute treatment is often attempted even beyond 6 h from symptoms onset fatal prognosis.In this observational study, we retrospectively analyzed patients AIS referred center...
The benefit of mechanical thrombectomy (MT) in patients with acute ischemic stroke (AIS) basilar artery occlusion (BAO) and a baseline National Institute Health Stroke Scale (NIHSS) score <10 is unclear because this subpopulation has been substantially excluded from large clinical trials. aim our study was to determine whether MT ± IV thrombolysis (IVT) improves functional outcomes compared IVT alone BAO NIHSS <10.
The Garcin syndrome is a rare condition characterized by multiple unilateral cranial nerve palsy, without neither long-tract involvement nor intracranial hypertension. Non-Hodgkin lymphoma systemic malignant disease that localizes in minority of cases the central nervous system. We report case revealed diffuse large B cell (DLBCL) located skull base and right kidney. reached diagnosis mean nonstandard, mini-invasive, transforamen ovale biopsy lesion (Hartel's route). nature renal mass was...
Background: Coronavirus disease 2019 (COVID-19) increases the risk of cerebral venous sinus thrombosis (CVST), and previous reports derived from small case series reported a high mortality in these patients, up to 40%. We assessed clinical characteristics outcomes an international cohort patients with COVID-CVST. Methods: This was registry study consecutive COVID-CVST diagnosed between March 2020 2023. As comparison, we used data CVST unrelated COVID-19,diagnosed 2017 2018 International...
Background: In atherothrombotic acute ischemic stroke (AIS), when the atheroma breaks down, clot can incorporate foam cells (FCs). The identification of correct etiology is paramount for secondary prevention. This study aims to evaluate presence FC in arterial clot, and determine whether patients with FCs without (NFCs) had different cerebrovascular risk factors, haemato-chemical parameters, atherosclerotic disease incidence, order predict etiological diagnosis. Methods: We collected 100...
In sub-Saharan Africa (SSA), stroke incidence is ~316 cases per 100,000 inhabitants and in 75% of SSA countries among the top three causes death. This epidemiological evolution results from exponential growth African population as well lack policies for prevention therapy. The Democratic Republic Congo one included a “low-income country” 2023 Organization Economic Co-operation Development's Development Assistance Committee List; its capital, Kinshasa, megalopolis with more than 18 million...
Abstract Background and aims Perihematomal hypoperfusion may lead to ischemic damage during intraparenchymal cerebral hemorrhage (ICH), resulting in worse prognosis. We aimed (1) investigate the relationship between serum biomarkers related oxidative stress vasoactive substances occurrence of perihematomal lesions ICH, (2) evaluate their correlation with volumetric evolution hematoma edema. Methods enrolled 28 patients affected by ICH. Blood samples were collected at timepoint T0 (admission...
Perihematomal hypoperfusion may lead to ischemic damage during intraparenchymal cerebral hemorrhage (ICH), resulting in worse prognosis. We aimed (1) investigate the relationship between serum biomarkers related oxidative stress and vasoactive substances occurrence of perihematomal lesions ICH (2) evaluate their correlation with volumetric evolution hematoma edema. enrolled 28 patients affected by ICH. Blood samples were collected at three different time points from symptom onset: T0, T1, T2...
Mechanical thrombectomy is a standard treatment for acute stroke, but it can be technically challenging in elderly patients with difficult vascular anatomy. To overcome this issue, we propose new endovascular approach called the “tightrope” technique. This technique uses stiff guidewire and angiographic catheter to straighten internal carotid artery (ICA) tortuosity, allowing guiding positioned next intracranial level. We retrospectively evaluated all procedures which was used. involves...
Purpose/Aim Diabetic chorea is a rare movement disorder associated with diabetes mellitus. We report the case of patient that benefited from pimozide and died pancreatic cancer.Case A 70-year-old woman presented pollakiuria involuntary movements left limbs since three months. Laboratory tests revealed high serum levels glycemia glycated haemoglobin. She was admitted to internal medicine department discharged one week later: insulin administered normalization blood glucose gradually...