Marco Longoni
A5052306890- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Stroke Rehabilitation and Recovery
- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Migraine and Headache Studies
- Amyotrophic Lateral Sclerosis Research
- Neuroscience and Neuropharmacology Research
- Long-Term Effects of COVID-19
- Neurogenetic and Muscular Disorders Research
- Cerebral Venous Sinus Thrombosis
- Peripheral Neuropathies and Disorders
- Neurological Complications and Syndromes
- Neurosurgical Procedures and Complications
- Climate Change and Health Impacts
- Neurological Disorders and Treatments
- Peripheral Artery Disease Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Autoimmune Neurological Disorders and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- COVID-19 and healthcare impacts
- Vasculitis and related conditions
- ECG Monitoring and Analysis
Ospedale “M. Bufalini” di Cesena
2020-2025
Ospedale G.B. Morgagni - L.Pierantoni
2020-2025
Fondazione IRCCS Istituto Neurologico Carlo Besta
2024
Sapienza University of Rome
2021-2024
Policlinico Umberto I
2024
University of Florence
2024
Azienda-Unita' Sanitaria Locale Di Cesena
2024
Brown University
2024
Instituto Nacional de Neurología y Neurocirugía
2024
University of British Columbia
2024
BACKGROUND: Small, randomized trials of patients with cervical artery dissection showed conflicting results regarding optimal stroke prevention strategies. We aimed to compare outcomes in treated antiplatelets versus anticoagulation. METHODS: This is a multicenter observational retrospective international study (16 countries, 63 sites) that included without major trauma. The exposure was antithrombotic treatment type (anticoagulation antiplatelets), and were subsequent ischemic hemorrhage...
Introduction: Mechanical thrombectomy (MT) is the standard treatment for acute ischemic stroke (AIS) due to anterior large vessel occlusion (LVO). Despite successful recanalization, some patients remain disabled after 3 months. Mechanisms that can cause futile recanalization (FR) are still largely unknown. We investigated if stress hyperglycemia might be associated with FR. Patients and methods: This a retrospective analysis of consecutive treated in four participating centers between...
Abstract Background There is a lack of data regarding patients aged 90 years or older undergoing mechanical thrombectomy and their predictors futile recanalization. Aims We sought to evaluate the recanalization in ≥ with large vessel occlusion thrombectomy. Methods This multi-center observational retrospective study included consecutively treated four capable centers between January 1st, 2016 30th March 2023. Futile was defined as experiencing 90-day poor outcome (mRS 3–6) despite successful...
Experimental studies have shown the role of excitotoxicity in pathogenesis ischemic brain lesions, and glutamate levels been found to be elevated CSF plasma from patients, early after stroke. In this study, we investigated whether platelets could involved mechanism altered Forty four 6 hours 9 months stroke, 15 age-related healthy controls with stroke risk factors or previous transient attack were enrolled. Glutamate levels, platelet release aggregation uptake assessed. Plasma increased up...
Background and purpose Comorbidity of acute ischaemic stroke with Covid‐19 is a challenging condition, potentially influencing the decision whether to administer intravenous thrombolysis (IVT). We aimed assess 1‐month outcome in patients infection who received IVT alone or before thrombectomy (bridging therapy). Methods As collaboration initiative promoted by Italian Stroke Organization, all units ( n = 190) were contacted invited participate data collection on IVT. Results Seventy‐five...
Increased incidence rates of amyotrophic lateral sclerosis (ALS) have been recently reported across various Western countries, although geographic and temporal variations in terms incidence, clinical features genetics are not fully elucidated. This study aimed to describe demographic, feature genotype-phenotype correlations ALS cases over the last decade Emilia Romagna Region (ERR). From 2009 2019, our prospective population-based registry ERR Northern Italy recorded 1613 patients receiving...
Background Women are underrepresented in stroke thrombectomy trials, and the impact of sex differences outcomes after is unclear. We performed a multicenter propensity matching study to define sex‐related outcome endovascular integrated results meta‐analysis. Methods included patients with anterior circulation large vessel occlusion consecutively treated at 2 Comprehensive Stroke Centres (2016–2023). Selection criteria reflected international guidelines. Through systematic review we selected...
In a primary study on proinflammatory genetic profiles in stroke, the authors found E469K polymorphism of intercellular adhesion molecule 1 (ICAM-1) highly represented subgroup with spontaneous cervical artery dissection (sCAD). They further investigated same variant second group 65 patients sCAD. An association between sCAD and EE genotype was confirmed (odds ratio 3.16; p < 0.01), indicating that predisposition is risk factor for
During the coronavirus disease 2019 (COVID-19) outbreak, a decrease of stroke's hospital admissions and reperfusion therapy has been reported worldwide. This retrospective observational study assessed volume stroke cases managed in Emergency Department (ED) therapies an Italian network with high incidence COVID-19, particularly to evaluate if in-hospital rerouting switch from drip-and-ship mothership model could assure adequate acute treatments. We compared data March 2020 those previous...
We sought to investigate whether there are gender differences in clinical outcome after stroke due large vessel occlusion (LVO) mechanical thrombectomy (EVT) a population of real-world patients.From the Italian Registry Endovascular Thrombectomy, we extracted and data patients treated for occlusion. compared safety outcomes men women who underwent EVT alone or combination with intravenous thrombolysis (IVT) total Propensity Score matched set.Among 3422 included study, 1801 (52.6%) were...
Abstract Objective The STANDLOW trial investigated whether first‐line antiseizure monotherapy with low doses has a similar efficacy to standard doses, but fewer adverse events, improved quality of life, and reduced costs for the National Health System. Methods Multicenter, randomized, parallel‐arm, single‐blind, non‐inferiority trial, comparing dose versus medications (carbamazepine, levetiracetam, valproate, zonisamide, oxcarbazepine, topiramate, lamotrigine, gabapentin, lacosamide) in...
Background/Objectives: C9ORF72 expansion is associated with significant phenotypic heterogeneity. This study aimed to characterize the clinical features of C9ALS patients from Emilia Romagna ALS registry (ERRALS) and compare them non-mutated (nmALS) matched for sex, age at onset, diagnostic delay, sourced same register. Methods: In total, 67 were compared 201 nmALS. Clinical data, phenotype, prognostic factors analyzed in two groups within group after stratification by sex. Results:...
The benefits and safety of mechanical thrombectomy (MT) in patients with prestroke disability, classified as modified Rankin Scale (mRS) score 3 to 4, anterior circulation stroke remain uncertain. This study aims evaluate these factors using data from the Italian Registry Endovascular Treatment Acute Stroke. We analyzed collected between 2015 2021, comparing functional outcomes (mRS), symptomatic intracerebral hemorrhage, recanalization rates (Thrombolysis Cerebral Infarction) at 90 days...
BACKGROUND: Patients presenting with cervical artery dissection (CAD) are at risk for subsequent ischemic events. We aimed to identify characteristics that associated increased of stroke after initial presentation CAD and evaluate the differential impact anticoagulant versus antiplatelet therapy in these high-risk individuals. METHODS: This was a preplanned secondary analysis STOP-CAD study (Antithrombotic Treatment Stroke Prevention Cervical Artery Dissection), multicenter international...
Glutamate may play an important role in the pathogenesis of migraine: glutamate release brain be involved development spreading depression and increased concentrations this amino acid have been reported plasma platelets from migraine patients. Here we assessed platelet uptake 25 patients affected by with aura (MA) without (MoA), comparing results a group 20 healthy matched controls. Both stimulated were high-performance liquid chromatography, both types migraine, although more markedly MA....
Mechanical thrombectomy with or without intravenous thrombolysis is indicated in the acute treatment of ischemic strokes caused by an emergent large-vessel occlusion (ELVO) within 6 hours from symptom onset. However, a significant proportion patients are referred to comprehensive stroke centers beyond this therapeutic time window. This study performed pooled analysis data trials which mechanical was onset.We searched for randomized controlled that compared best medical due ELVO and reported...