A5035544791- Autophagy in Disease and Therapy
- Radioactivity and Radon Measurements
- Mitochondrial Function and Pathology
- Radioactive contamination and transfer
- Effects and risks of endocrine disrupting chemicals
- Adipose Tissue and Metabolism
- Nuclear Physics and Applications
- ATP Synthase and ATPases Research
- Estrogen and related hormone effects
- Radiation Detection and Scintillator Technologies
- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- 3D Surveying and Cultural Heritage
- Sirtuins and Resveratrol in Medicine
- Acute Myeloid Leukemia Research
- Nitric Oxide and Endothelin Effects
- Neurological Disease Mechanisms and Treatments
- Nuclear and radioactivity studies
- Graphite, nuclear technology, radiation studies
- Advanced Glycation End Products research
- Image Processing and 3D Reconstruction
- Cancer Genomics and Diagnostics
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- MicroRNA in disease regulation
- Chemotherapy-induced cardiotoxicity and mitigation
Istituto Neurologico Mediterraneo
2016-2025
Medical University of Vienna
2020-2025
Max Perutz Labs
2025
Vienna Biocenter
2025
Agenzia Regionale per la Protezione dell'ambiente ligure
2001-2023
Azienda Regionale per la protezione dell'ambiente Lombardia
2001-2023
Lombardia Informatica (Italy)
2006-2023
Istituto di Genetica Molecolare
2019
Duke University
2014-2019
Sapienza University of Rome
2018
Abstract Personalized medicine aims to match the right drug with patient by using specific features of individual patient's tumor. However, current strategies personalized therapy matching provide treatment opportunities for less than 10% patients cancer. A promising method may be profiling biopsy specimens single-cell resolution directly quantify effects. We prospectively tested an image-based functional precision (scFPM) approach guide treatments in 143 advanced aggressive hematologic...
Abstract Aims Low-grade endotoxaemia is detectable in human circulation but its role thrombosis still unclear. Methods and results We measured serum lipopolysaccharide (LPS) concentration, soluble P-selectin (sP-selectin), a marker of platelet activation, zonulin, gut permeability, peripheral circulation, coronary thrombi, intracoronary blood patients with ST-elevation myocardial infarction (STEMI, n = 50) stable angina (SA) (n 50), respectively, controls 50). Experimental study was carried...
The identification of the mechanisms predisposing to stroke may improve its preventive and therapeutic strategies in patients with essential hypertension. role macroautophagy/autophagy development hypertension-related needs be clarified. We hypothesized that a defective autophagy favor spontaneous by promoting mitochondrial dysfunction. studied stroke-prone spontaneously hypertensive (SHRSP) rat, which represents clinically relevant model associated high blood pressure. assessed autophagy,...
Bacterial lipopolysaccharides are recognized as the major cause of pyrogenic reactions from parenteral solutions. Molecular filtration was used to remove these molecules (endotoxins) contaminated Because bacterial can exist in different states aggregation, depending on composition solution they suspended in, full range possible aggregation examined by using filters with a wide pore sizes. Filters sizes retained endotoxin lipopolysaccharide presumed be vesicle form, micelle or...
Abstract Aims Here, we aimed to determine the therapeutic effect of longevity-associated variant (LAV)-BPIFB4 gene therapy on atherosclerosis. Methods and results ApoE knockout mice (ApoE−/−) fed a high-fat diet were randomly allocated receive LAV-BPIFB4, wild-type (WT)-BPIFB4, or empty vector via adeno-associated viral injection. The primary endpoints study assess (i) vascular reactivity (ii) atherosclerotic disease severity, by Echo-Doppler imaging, histology ultrastructural analysis....
Endocrine disrupting chemicals (EDCs) are identified for their ability to perturb the homeostasis of endocrine system and hormonal balance. The male reproductive is under close control hormones each change in concentration time exposition action can induce a deregulation its physiology. In this review we summarize most recent studies on two main categories EDCs with different action: estrogenic bisphenol A alkylphenols anti-androgenic phthalates. This describes effects these substances system.