A5055802409- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac Valve Diseases and Treatments
- Cerebrovascular and Carotid Artery Diseases
- COVID-19 and healthcare impacts
- Atrial Fibrillation Management and Outcomes
- Climate Change and Health Impacts
- Cardiac Arrest and Resuscitation
- Air Quality and Health Impacts
- Acute Ischemic Stroke Management
- Cardiac Arrhythmias and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Peripheral Artery Disease Management
- Vascular Procedures and Complications
- Cardiovascular Function and Risk Factors
- Cardiac Ischemia and Reperfusion
- Atherosclerosis and Cardiovascular Diseases
- COVID-19 Clinical Research Studies
- Aortic aneurysm repair treatments
- Cardiac electrophysiology and arrhythmias
- Venous Thromboembolism Diagnosis and Management
- Blood Pressure and Hypertension Studies
- Advanced MRI Techniques and Applications
- Mechanical Circulatory Support Devices
Ospedale Santa Maria Goretti
2017-2025
University of Catania
2016-2024
Ospedale Maggiore
2024
Magna Graecia University
2024
University of Naples Federico II
2024
Center for Advanced Studies Research and Development in Sardinia
2023
Liverpool John Moores University
2023
University of Liverpool
2023
Sapienza University of Rome
1996-2023
Liverpool Heart and Chest Hospital
2023
BACKGROUND Brief episodes of ischemia render the heart more resistant to subsequent ischemia; this phenomenon has been called ischemic preconditioning. In some animal species, myocardial preconditioning appears be due activation ATP-sensitive K+ (KATP) channels. The role played by KATP channels in humans remains unknown. aim study was establish whether glibenclamide, a selective channel blocker, abolishes observed during coronary angioplasty following repeated balloon inflations. METHODS AND...
Abstract Aims The CLIMA study, on the relationship between coronary plaque morphology of left anterior descending artery and twelve months clinical outcome, was designed to explore predictive value multiple high-risk features in same lesion [minimum lumen area (MLA), fibrous cap thickness (FCT), lipid arc circumferential extension, presence optical coherence tomography (OCT)-defined macrophages] as detected by OCT. Composite cardiac death target segment myocardial infarction primary...
Randomized studies have shown that the use of coronary-artery stenting as initial treatment for coronary stenosis is associated with a lower risk restenosis than standard angioplasty. We prospectively investigated efficacy these two approaches in selected patients isolated proximal left anterior descending artery.
Background— Clinical consequences of optical coherence tomographic (OCT) high-definition visualization plaque/stent structures in acute patients remain undefined. In this retrospective substudy, we assessed the prognostic impact postprocedural culprit lesion OCT findings with coronary syndrome undergoing percutaneous intervention. Methods and Results— CLI-OPCI (Centro per la Lotta Contro L’Infarto-Optimization Percutaneous Coronary Intervention) database collecting cases from 5 independent...
Abstract Aims Here, we aimed to determine the therapeutic effect of longevity-associated variant (LAV)-BPIFB4 gene therapy on atherosclerosis. Methods and results ApoE knockout mice (ApoE−/−) fed a high-fat diet were randomly allocated receive LAV-BPIFB4, wild-type (WT)-BPIFB4, or empty vector via adeno-associated viral injection. The primary endpoints study assess (i) vascular reactivity (ii) atherosclerotic disease severity, by Echo-Doppler imaging, histology ultrastructural analysis....
The role of A1 adenosine receptors in preconditioning humans is unknown. To establish whether bamiphylline, a selective antagonist receptors, abolishes ischaemic man, 36 consecutive patients undergoing single-vessel coronary angioplasty were randomized to receive intravenous infusion bamiphylline (5 mg. kg−1)or placebo (0·9% NaCl) immediately prior the procedure. mean values (±1 SD) ST segment shifts on surface and intracoronary electrocardiograms measured at end first second balloon...
BACKGROUND: Infection due to severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), i.e. coronavirus-associated disease 2019 (COVID-2019), may occasionally lead distress syndrome (ARDS), requiring in the most cases extracorporeal membrane oxygenation (ECMO). Yet, limited data, if any, are currently available on role of ECMO critically ill patients with COVID-19. We aimed at providing a snapshot analysis for COVID-19 Europe.METHODS: Freely data reported by European Extracorporeal Life...
The initial data of the International Study on Acute Coronary Syndromes - ST Elevation Myocardial Infarction COVID-19 showed in Europe a remarkable reduction primary percutaneous coronary intervention procedures and higher in-hospital mortality during phase pandemic as compared with prepandemic period. aim current study was to provide final results registry, subsequently extended outside larger inclusion period (up June 2020) longer follow-up 30 days).This is retrospective multicentre...
Abstract The mitochondrial uncoupling protein 2 (UCP2) plays a protective function in the vascular disease of both animal models and humans. UCP2 downregulation upon high-salt feeding favors dysfunction knock-out mice, accelerates cerebrovascular renal damage stroke-prone spontaneously hypertensive rat. Overexpression counteracts negative effects models. We tested vitro ability to stimulate autophagy mitophagy as mechanism mediating its exposure endothelial tubular cells. silencing reduced...
NPPA/atrial natriuretic peptide (natriuretic type A) exerts critical pleiotropic effects in the cardiovascular system, limiting cardiomyocyte hypertrophy and death, reducing cardiac fibrosis promoting vascular integrity. However, molecular mechanisms underlying these beneficial still need to be clarified. We demonstrated for first time that macroautophagy/autophagy is involved local protective of NPPA cardiomyocytes (CMs), both vitro vivo. Exogenous rapidly activates autophagy CMs through...