A5024586943- Autophagy in Disease and Therapy
- Cardiac Fibrosis and Remodeling
- Chemotherapy-induced cardiotoxicity and mitigation
- Aortic aneurysm repair treatments
- Cardiac Ischemia and Reperfusion
- Vitamin C and Antioxidants Research
- Signaling Pathways in Disease
- Cancer Treatment and Pharmacology
- Aortic Disease and Treatment Approaches
- Heart Failure Treatment and Management
- Electrospun Nanofibers in Biomedical Applications
- Muscle metabolism and nutrition
- Genetics, Aging, and Longevity in Model Organisms
- Extracellular vesicles in disease
- Adipose Tissue and Metabolism
- Exercise and Physiological Responses
- Galectins and Cancer Biology
- Acute Ischemic Stroke Management
- Hydrogen's biological and therapeutic effects
- PI3K/AKT/mTOR signaling in cancer
- Studies on Chitinases and Chitosanases
- Peripheral Artery Disease Management
- Cancer-related molecular mechanisms research
- Gut microbiota and health
- Muscle Physiology and Disorders
Istituto Neurologico Mediterraneo
2018-2024
Sapienza University of Rome
2017-2023
Bicuspid valve disease is associated with the development of thoracic aortic aneurysm. The molecular mechanisms underlying this association still need to be clarified. Here, we evaluated circulating levels T and B lymphocyte subsets vascular diseases in patients bicuspid or tricuspid without We unveiled that MAIT, CD4+IL−17A+, NKT cell were significantly reduced cases, when compared cases either presence absence Among valve, these cells higher those also affected by Similar data obtained...
NPPA/atrial natriuretic peptide (natriuretic type A) exerts critical pleiotropic effects in the cardiovascular system, limiting cardiomyocyte hypertrophy and death, reducing cardiac fibrosis promoting vascular integrity. However, molecular mechanisms underlying these beneficial still need to be clarified. We demonstrated for first time that macroautophagy/autophagy is involved local protective of NPPA cardiomyocytes (CMs), both vitro vivo. Exogenous rapidly activates autophagy CMs through...
Intensive physical exercise may cause increase oxidative stress and muscular injury in elite football athletes. The aim of this study was to exploit the effect cocoa polyphenols on injuries induced by intensive players. Oxidant/antioxidant status markers muscle damage were evaluated 24 players 15 controls. Furthermore, randomly assigned either a dark chocolate (>85% cocoa) intake ( n = 12) or control group for 30 days randomized controlled trial. Oxidative stress, antioxidant status,...
Heart failure is a major side effect of doxorubicin (DOX) treatment in patients with cancer. However, the mechanisms underlying development DOX-induced heart need to be addressed. This study aims test whether serine/threonine kinase MST1, Hippo pathway component, contributes myocardial injury. C57BL/6J WT mice and cardiomyocyte-specific dominant-negative MST1 (kinase-dead) overexpression received three weekly injections DOX, reaching final cumulative dose 18 mg/kg. Echocardiographic,...
Background and Purpose Oxidative stress insufficient autophagy activity are associated with inflammatory processes common features of many cardiovascular diseases (CVDs). We investigated if a combination natural activators could modulate oxidative stress, platelet aggregation endothelial cell survival function in response to stress. Experimental Approach Ex vivo activation, H 2 O production were measured platelets subjects at high risk, including smokers, patients metabolic syndrome (MetS)...
Thoracic aortic aneurysms (TAA) pathogenesis and progression include many mechanisms. The authors investigated the role of autophagy, oxidative stress, endothelial dysfunction in 36 TAA patients 23 control patients. Univariable multivariable analyses were performed. displayed higher stress then Autophagy group was reduced. association autophagy with disease supports these processes TAA. demonstrate a putative Nox2 dysregulation human These findings could pinpoint novel treatment targets to...
Background: Aging is an independent risk factor for cardiovascular diseases. The autophagy process may play a role in delaying aging and improving function aging. Data regarding atrial fibrillation (AF) patients are lacking. Methods: A post hoc analysis of the prospective ATHERO-AF cohort study, including 150 AF sex- age-matched control subjects (CS), was performed. For analysis, population divided into three age groups: <50−60, 61−70, >70 years. Oxidative stress (Nox2 activity hydrogen...
Background The role of microRNAs dysregulation in tobacco cigarette smoking-induced vascular damage still needs to be clarified. We assessed the acute effects smoking on endothelial cell-related circulating healthy subjects. In addition, we investigated potential smoking-dependent cell damage. Methods and Results A panel endothelial-related was quantified subjects before after 1 cigarette. Serum levels miR-155 were found significantly increased shortly smoking. also observed a progressive...
The association between diabetes and cardiovascular diseases is well known. Related macro- microangiopathies frequently induce hypoxia consequently energy failure to satisfy the jeopardized myocardium basal needs. Additionally, it widely accepted that impairs endothelial nitric oxide synthase (eNOS) activity, resulting in diminished (NO) bioavailability consequent cell dysfunction. In this study, we analyzed embryonic heart-derived H9c2 response hypoxic stress after administration of a high...
Atrial natriuretic peptide (ANP), a cardiac hormone involved in the regulation of water/sodium balance and blood pressure, is also secreted by endothelial cells, where it exerts protective effects response to stress. Autophagy an intracellular self-renewal process degradation dysfunctional cytoplasmic elements. ANP was recently reported act as extracellular regulator autophagy. However, its role autophagy has never been investigated. Here, we tested human umbilical vein cells (HUVECs). We...
Abstract Bicuspid aortic valve (BAV) disease is recognized to be a syndrome with complex and multifaceted pathophysiology. Its progression modulated by diverse evolutionary conserved pathways, such as Notch-1 pathway. Emerging evidence also highlighting the key role of TLR4 signaling pathway in pathologies their related complications, sporadic ascending aorta aneurysms (AAA). Consistent these observations, we aimed evaluate both BAV its common complication, AAA. To this aim, 70 subjects (M/F...
Trehalose, spermidine, nicotinamide, and polyphenols have been shown to display pro-autophagic antioxidant properties, eventually reducing cardiovascular ischemic complications. This study aimed investigate whether a mixture of these components improves maximal walking distance (MWD) in peripheral artery disease (PAD) patients. Nitrite/nitrate (NOx), endothelin-1, sNOX2-dp, H2O2 production, break-down activity (HBA), ATG5 P62 levels, flow-mediated dilation (FMD), MWD were evaluated 20 PAD...
Chronic cardiac muscle inflammation and subsequent fibrotic tissue deposition are key features in Duchenne Muscular Dystrophy (DMD). The treatment of choice for delaying DMD progression both skeletal corticosteroids, supporting the notion that chronic heart plays a pivotal role fibrosis dysfunction. Nevertheless, considering adverse effects associated with long-term corticosteroid treatments, there is need novel anti-inflammatory therapies. In this study, we used our recently described...
Cardiac stromal cells (CSCs) embrace multiple phenotypes and are a contributory factor in tissue homeostasis repair. They can be exploited as therapeutic mediators against cardiac fibrosis remodeling, but their survival cardioprotective properties decreased by microenvironmental cues. We evaluated the impact of autophagy modulation different pharmacological/genetic approaches on viability phenotype murine CSCs, which had been subjected to nutrient deprivation or hyperglycemia, order mimic...
Oxidative stress and impaired autophagy are directly indirectly implicated in exercise-mediated muscle injury. Trehalose, spermidine, nicotinamide, polyphenols possess pro-autophagic antioxidant properties, could therefore reduce exercise-induced damage to skeletal muscle. The aim of this study was investigate whether a mixture these compounds able improve injury biomarkers endurance athletes through the modulation oxidative autophagic machinery. sNOX2-dp; H2O2 production; breakdown activity...
Abstract Introduction Diabetes leads to endothelial dysfunction, a main determinant of several cardiovascular diseases. The molecular mechanisms underlying the effects hyperglycemia in cells are not fully characterized. Autophagy, intracellular process by which cell digests and recycles senescent or damaged cytoplasmic elements, exerts protective effects, limiting cardiac vascular injury presence stress. However, it is unclear how modulates autophagy cells. Purpose In this study, we...