A5066059339- Cardiac Valve Diseases and Treatments
- Aortic Disease and Treatment Approaches
- Aortic aneurysm repair treatments
- Infective Endocarditis Diagnosis and Management
- Connective tissue disorders research
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac and Coronary Surgery Techniques
- Cardiac Structural Anomalies and Repair
- Infectious Aortic and Vascular Conditions
- Pulmonary Hypertension Research and Treatments
- Inflammatory Biomarkers in Disease Prognosis
- Mechanical Circulatory Support Devices
- Acute Myocardial Infarction Research
- Cardiovascular Function and Risk Factors
- Cardiac pacing and defibrillation studies
- Venous Thromboembolism Diagnosis and Management
- Cardiac tumors and thrombi
- Coronary Artery Anomalies
- Adipokines, Inflammation, and Metabolic Diseases
- Antiplatelet Therapy and Cardiovascular Diseases
- Anesthesia and Neurotoxicity Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cardiac Ischemia and Reperfusion
- Sarcoma Diagnosis and Treatment
- Blood properties and coagulation
University of Palermo
2009-2025
University of Naples Federico II
2016-2025
University of Rome Tor Vergata
2018-2024
Policlinico Tor Vergata
2018-2022
Ospedale San Luigi Gonzaga
2021
Children's Hospital of Michigan
2019
Johns Hopkins Children's Center
2019
Johns Hopkins University
2019
Children's National
2019
Children's Mercy Hospital
2019
Bicuspid valve disease is associated with the development of thoracic aortic aneurysm. The molecular mechanisms underlying this association still need to be clarified. Here, we evaluated circulating levels T and B lymphocyte subsets vascular diseases in patients bicuspid or tricuspid without We unveiled that MAIT, CD4+IL−17A+, NKT cell were significantly reduced cases, when compared cases either presence absence Among valve, these cells higher those also affected by Similar data obtained...
Thoracic aortic aneurysm (TAA) is a progressive disorder involving gradual dilation of ascending and/or descending thoracic aorta with dissection or rupture as complications. It occurs sporadic defined syndromes/familial forms.Genetic, molecular and cellular mechanims TAA forms are poorly characterized known. Thus, our interest has been focused on investigating the role genetic variants transforming growth factor-β (TGF-β) pathways in risk. On other hand, no data TGF-β pathway exist until...
The involvement of different factors in the onset thoracic aortic aneurysm (TAA) patients with a bicuspid valve (BAV) vs those tricuspid (TAV) is well recognized. However, molecular, genetic and cellular mechanisms driving TAA remain unclear. aim this study was to identify involved development BAV TAV.Aorta specimens DNA samples were collected from 24 (18 men 6 women; mean age: 54.2 ± 14.39 years) 110 TAV (79 31 women, 66 9.8 patients. A control group 128 subjects (61 67 woman, 61.1 5.8 also...
Bicuspid aortic valve (BAV) is frequently associated with the development of ascending aneurysm, even if underlying mechanisms remain to be clarified. Here, we investigated a deregulation Notch1 signaling pathway and endothelial progenitor cells (EPCs) number BAV disease an early aneurysm (AAA) onset. For this purpose, 70 subjects (M/F 50/20; mean age: 58.8 ± 14.8 years) tricuspid (TAV) 35/35; 69.1 12.8 AAA complicated or not, were included. Interestingly, patients showed significant...
Thoracic aorta shows with advancing age various changes and a progressive deterioration in structure function. As result, vascular remodeling (VR) medial degeneration (MD) occur as pathological entities responsible principally for the sporadic TAA onset. Little is known about their genetic, molecular, cellular mechanisms. Recent evidence proposing strong role of chronic immune/inflammatory process evocation progression. Thus, we evaluated potential Toll like receptor- (TLR-) 4-mediated...
Aneurysm diameter and growing rate does not represent a definite parameter for operation in bicuspid aortic valve (BAV), ascending aneurysm normal root patients. Thus, we investigated histological immunohistochemical aspects of different segments aorta (precisely, without dilatation, aneurysmatic tubular portion, dissected aorta) genetic features patients with BAV complication (aneurysm or dissection). Aorta tissue samples 24 were examined. The comprised 18 men 6 women; the mean age was 54.2...
Aortic aneurysms are a serious health concern as their rupture leads to high morbidity and mortality. Abdominal aortic (AAAs) thoracic (TAAs) exhibit differences similarities in pathophysiological pathogenetic features. AAA is multifactorial disease, mainly associated with atherosclerosis, characterized by relevant inflammatory response calcification. TAA rarely atherosclerosis some cases genetic mutations such Marfan syndrome (MFS) bicuspid valve (BAV). MFS-related non-genetic or sporadic...
We retrospectively analyzed early results of coronary artery bypass grafting (CABG) surgery using two different types cardioplegia for myocardial protection: antegrade intermittent warm blood or cold crystalloid cardioplegia. From January 2015 to October 2016, 330 consecutive patients underwent isolated on-pump CABG. Cardiac arrest was obtained with use (WBC group, n = 297) (CCC 33), according the choice surgeon. Euroscore II and preoperative characteristics were similar in both groups,...
Marfan syndrome (MFS) is a connective tissue disease caused by mutations in the FBN1 gene, leading to alterations extracellular matrix microfibril assembly and early formation of thoracic aorta aneurysms (TAAs). Non-genetic TAAs share many clinico-pathological aspects with MFS deregulation some microRNAs (miRNAs) has been demonstrated be involved progression TAA. In this study, 40 patients undergoing elective ascending surgery were enrolled compare TAA histomorphological features, miRNA...
Thoracic aortic aneurysms (TAAs) represent a serious health concern, as they are associated with early dissection and rupture. TAA formation is triggered by genetic conditions, in particular Marfan syndrome (MFS) bicuspid valve (BAV). During the aneurysmatic process, endothelial cells can undergo endothelial-to-mesenchymal transition (End–MT) consequent phenotypic functional alterations. We previously documented that MFS characterized miR-632–driven End–MT exacerbation, whereas BAV...
Telomeres have been postulated as a universal clock that shortens in parallel with cellular aging. They are specialized DNA-protein structures at the ends of chromosome remarkable functions--preventing their recognition double-stranded DNA breaks, protecting recombination and degradation, avoiding damage response. Telomere shortening is currently considered best aging marker, but also predictor for age-related diseases, including cardiovascular diseases. Biological age clearly seems to be...
The emerging evidence emphasizes red blood cell distribution width (RDW) as optimal prognostic biomarker for cardiovascular diseases. However, several clinical biases impede its application. Recent recommendations suggest combining RDW with other biomarkers. Accordingly, we propose evaluating the well-recognized biomarkers of vascular aging (i.e., leukocyte telomere length and telomerase activity, reduced levels endothelial progenitor cells [EPCs]) RDW, predicting risk onset prognosis...
Objective The objective of this study was to evaluate the effectiveness Penn classification in predicting in-hospital mortality after surgery acute type A aortic dissection patients.Methods We evaluated 58 patients (42 men and 16 women; mean age 62.17 ± 10.6 years) who underwent emergency for between September 2003 June 2010 our department. investigated correlation pre-operative malperfusion outcome surgery.Results Twenty-eight (48%) were class Aa (absence branch vessel or circulatory...
Marfan syndrome (MFS) is a connective tissue disorder caused by FBN1 gene mutations leading to TGF-β signaling hyperactivation, vascular wall weakness, and thoracic aortic aneurysms (TAAs). The pathogenetic mechanisms are not completely understood patients undergo early surgery prevent TAA ruptures. We previously reported miR-632 upregulation in MFS tissues compared with non-genetic tissues. DNAJB6 target of cancer plays critical role blocking epithelial-to-mesenchymal transition inhibiting...
Background: Previous studies have demonstrated that polymorphisms involved in immune genes can affect the risk, pathogenesis, and outcome of thoracic ascending aortic aneurysms (TAAA). Here, we explored potential associations five functional promoter interleukin-6 (IL-6), IL-1B, IL-1A, IL-18, Tumor necrosis factor (TNF)A with TAAA. Methods: 144 TAAA patients 150 age/gender matched controls were typed using KASPar assays. Effects on telomere length levels related histopathological serological...