A5006854826- Cardiac Valve Diseases and Treatments
- Aortic Disease and Treatment Approaches
- Infective Endocarditis Diagnosis and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Aortic aneurysm repair treatments
- Cardiac and Coronary Surgery Techniques
- Cardiac Structural Anomalies and Repair
- Cerebrovascular and Carotid Artery Diseases
- Coronary Interventions and Diagnostics
- Congenital Heart Disease Studies
- Mechanical Circulatory Support Devices
- Cardiac tumors and thrombi
- Bone health and treatments
- Renaissance and Early Modern Studies
- Anesthesia and Neurotoxicity Research
- Cardiac Ischemia and Reperfusion
- Vitamin D Research Studies
- Intracranial Aneurysms: Treatment and Complications
- Atrial Fibrillation Management and Outcomes
- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Cancer Diagnosis and Treatment
- Bone health and osteoporosis research
- Acute Myocardial Infarction Research
Policlinico Tor Vergata
2014-2024
University of Rome Tor Vergata
2015-2024
University of Siena
1976-2020
Northern General Hospital
2017
San Diego Cardiac Center
2017
Bocconi University
2010-2017
Politecnico di Milano
2010-2012
Fundación Juan March
2010
Foro Italico University of Rome
2009
Island Hospital
1990-2009
Estrogen treatment improves calcium malabsorption induced by surgical or natural menopause, but the mechanisms involved are still under debate, with both increased production of 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] and improved peripheral responsiveness to steroid having been proposed. To address this issue, we studied effect short term administration 1,25-(OH)2D3 (1 μg/day for 7 days) on intestinal fractional absorption 47Ca (47Ca FA) vertebral bone density, measured dual photon...
Abstract OBJECTIVES In the last decades, 4 different scores for prediction of mortality following surgery type A acute aortic dissection (TAAD) were proposed. We aimed to validate these in a large external multicentre cohort. METHODS retrospectively analysed patients who underwent TAAD between 2000 and 2020. Patients enrolled from 10 centres 2 European countries. Outcomes early (30-day and/or in-hospital) 1-year mortality. Discrimination, calibration observed/expected (O/E) ratio evaluated....
Abstract Background We have evaluated in a single-center retrospective study early and mid-term outcomes of intermittent warm blood St. Thomas cold crystalloid cardioplegia patients referred for coronary artery bypass grafting (CABG) due to acute syndromes (ACS). From January 2018 December 2023, 336 consecutive underwent isolated on-pump CABG (unstable angina = 234, 69.6%; N-STE-myocardial infarction 66, 19.6%; STE-myocardial 36, 10.7%). Myocardial protection was achieved using (WBC, n 215,...
This study examined the characteristics of 147 PDB cases from Italy. Our data showed a reduced clinical severity with respect to other populations and provided further support importance environmental factors (rural area residence animal contact) in pathogenesis PDB. Familial aggregation was observed 15% cases.The etiology Paget's disease bone (PDB) remains unknown. Current evidence suggests that interactions among genetic or exogenous seem be necessary for expression. Major epidemiological...
Objectives Conducting system defects are common in patients with aortic valve disease. Aortic replacement may result further conduction abnormalities requiring permanent pacemaker implantation. The aim of our study was to identify the incidence and predictors for postoperative 30-day implantation undergoing isolated replacement, effect an accurate surgical technique order prevent Methods Data from 261 consecutive (mean age 69 ± 12 years, 136 men) January 2004 2008 were analyzed...
Prosthetic valve endocarditis (PVE) is an uncommon yet dreadful complication in patients with prosthetic valves that requires a distinct analysis from native endocarditis. The present study aims to investigate independent risk factors for early surgical outcomes PVE. A retrospective cohort was conducted 8 Italian Cardiac Surgery Units January 2000 December 2013 by enrolling all PVE undergoing treatment. total of 209 consecutive were included the study. During period, global rate procedures...
Background: The cardiac surgery-associated acute kidney injury (CSA-AKI) occurs in up to 1 out of 3 patients. Off-pump coronary artery bypass grafting (OPCABG) is one the major surgeries leading CSA-AKI. Early identification and timely intervention are clinical significance for In this study, we aimed establish a prediction model off-pump grafting-associated (OPCABG-AKI) after surgery based on machine learning methods. Methods: preoperative intraoperative data 1,041 patients who underwent...
The sinuses of Valsalva are known to contribute the normal function aortic valve. Little is about their role in promoting coronary artery blood flow. aim this study was compare flow characteristics among patients undergoing a Bentall operation by means conventional cylindrical Dacron conduit or with new pseudosinuses retaining natural after valve and supracoronary ascending aorta replacement.One year procedure standard (7 patients, group A) B), replacement (control group, 7 C) velocity...
The aim of the study was to compare early and long-term results pectoralis muscle flap reconstruction with those sternal rewiring following failed closure. Primary outcomes were survival failure rate. Respiratory function, chronic pain quality life also evaluated. In a propensity-score matching analysis, 94 patients who underwent reconstruction, 40 selected; 20 bilateral flaps (Group 1) 2). Survival rates evaluated by in-hospital records at follow-up. function measures, including vital...
We retrospectively analyzed early results of coronary artery bypass grafting (CABG) surgery using two different types cardioplegia for myocardial protection: antegrade intermittent warm blood or cold crystalloid cardioplegia. From January 2015 to October 2016, 330 consecutive patients underwent isolated on-pump CABG. Cardiac arrest was obtained with use (WBC group, n = 297) (CCC 33), according the choice surgeon. Euroscore II and preoperative characteristics were similar in both groups,...
Coronary endarterectomy (CE) represents a useful adjunctive technique to coronary artery bypass grafting (CABG) in the presence of diffuse disease. Nevertheless, long-term patency graft remains unclear, and no standard anticoagulation antiplatelet protocols exist for use after CE. The aim this retrospective study was evaluate possibly clarify role single (SAT) versus dual therapy (DAT) at mid-term follow-up. Between January 2006 December 2013, CE performed 90 patients (mean age 67 ± 8.2...
Thoracic aortic aneurysms (TAAs) represent a serious health concern, as they are associated with early dissection and rupture. TAA formation is triggered by genetic conditions, in particular Marfan syndrome (MFS) bicuspid valve (BAV). During the aneurysmatic process, endothelial cells can undergo endothelial-to-mesenchymal transition (End–MT) consequent phenotypic functional alterations. We previously documented that MFS characterized miR-632–driven End–MT exacerbation, whereas BAV...