A5101544373- Bone health and osteoporosis research
- Bone health and treatments
- Vitamin D Research Studies
- Bone Metabolism and Diseases
- Body Composition Measurement Techniques
- Cerebral Palsy and Movement Disorders
- Estrogen and related hormone effects
- Bone and Joint Diseases
- Bone Tumor Diagnosis and Treatments
- Medical Imaging and Pathology Studies
- Nutrition and Health in Aging
- Children's Physical and Motor Development
- Cancer Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- Infant Development and Preterm Care
- Folate and B Vitamins Research
- Radiopharmaceutical Chemistry and Applications
- Parathyroid Disorders and Treatments
- Lower Extremity Biomechanics and Pathologies
- Inclusion and Disability in Education and Sport
- Regulation of Appetite and Obesity
- Menopause: Health Impacts and Treatments
- Laser Applications in Dentistry and Medicine
- Cancer and Skin Lesions
- Pituitary Gland Disorders and Treatments
University of Siena
2006-2024
Fondazione Stella Maris
2021-2023
Ospedale Santa Maria alle Scotte
2014
Azienda Ospedaliera Ospedale Civile di Legnano
2013
Policlinico Universitario di Catania
2011
Casa Sollievo della Sofferenza
1998
University of Pisa
1993
Sapienza University of Rome
1990
University of Florence
1985
Abstract Male osteoporosis is an increasingly important health problem. It known that sex steroid hormones play role in regulating bone turnover and mass males as well females. However, the exact mechanism of loss men remains unknown. In present study, 200 elderly (age range, 55–85 yr) were followed for 4 yr to evaluate relationships between hormone levels, markers, mineral density, rates loss. Femoral lumbar ultrasound parameters at os calcis, serum testosterone (T), estradiol (E2), SHBG...
Recently it was found that thyrotropin (TSH) receptors are present both in osteoclast and osteoblast TSH can modulate bone remodeling independent of thyroid hormones. The aim this study was, firstly, to evaluate the effects acute administration on markers men women and, secondly, if these mediated by variations serum osteoprotegerin (OPG) receptor activator nuclear factor-KB ligand (RANKL).We studied 30 thyroidectomized patients (10 premenopausal 10 postmenopausal women, men) affected...
Abstract This randomized study compared different intravenous bisphosphonates in PDB. Zoledronate was superior with respect to pamidronate achieving biochemical remission, therapeutic response maintained most patients at 15 mo. Single neridronate and zoledronate infusion showed a similar efficacy up 90% of nonresponders pamidronate. Introduction: Intravenous represent common therapy for Paget's disease bone (PDB). However, there have been few head trials comparing bisphosphonates. Materials...
Even though SQSTM1 gene mutations have been identified in a consistent number of patients, the etiology Paget's disease bone (PDB) remains part unknown. In this study we analyzed 533 608 consecutive PDB patients from several regions, including high-prevalence area Campania (also characterized by increased severity PDB, higher familial cases, and peculiar phenotypic characteristics as giant cell tumor). Eleven different (Y383X, P387L, P392L, E396X, M401V, M404V, G411S, D423X, G425E, G425R,...
To assess the impact on stroke outcome of statin use in acute phase after IV thrombolysis.Multicenter study prospectively collected data 2,072 patients treated with thrombolysis. Outcome measures efficacy were neurologic improvement (NIH Stroke Scale [NIHSS] ≤ 4 points from baseline or NIHSS = 0) and major (NIHSS 8 at 7 days favorable (modified Rankin [mRS] 2) excellent functional (mRS 1) 3 months. safety 7-day deterioration ≥ death), symptomatic intracerebral hemorrhage type 2 death within...
Intravenous loop diuretics are a cornerstone of therapy in acutely decompensated heart failure (ADHF). We sought to determine if there any differences clinical outcomes between intravenous bolus and continuous infusion diuretics. Subjects with ADHF within 12 hours hospital admission were randomly assigned or twice daily furosemide. There three co-primary endpoints assessed from discharge: the mean paired changes serum creatinine, estimated glomerular filtration rate (eGFR), reduction B-type...
The aims of the study were to quantify prevalence asymptomatic coeliac disease (CD) in a cohort osteoporotic females, and investigate features bone loss.We studied 255 women (mean age 66.6 +/- 8.5 SD) with primary osteoporosis (WHO diagnostic criteria). After first CD screening measure serum IgG antigliadin antibodies (IgG-AGA), 53 showed positive test: tissue transglutaminase (TG-ab) subsequently determined confirm diagnosis CD. Bone metabolism was evaluated by: urinary calcium, phosphate,...
Abstract We examined the prevalence of PDB in Italy from radiological, scintigraphic, and biochemical surveys two Italian towns. Prevalence rates varied 0.7% to 2.4%, were higher males than females, slightly differed between Unlike previous studies populations British descent, no secular trend for a decreasing emerged. Introduction: Clinical, necropsy data different countries suggested pronounced geographical variations Paget's disease bone (PDB). Despite impact on population, there are...
Abstract Epidemiological studies of Paget's disease bone (PDB) suggest a pronounced geographical variation in the prevalence and decrease clinical severity over time. To analyze epidemiological features PDB Italy, we recently established registry Italian cases performed radiological, biochemical, scan surveys towns Siena Turin. The overall Italy varied between 0.7% 2.4%. Prevalence rates increased with age were higher men than women. We observed clinically confirmed familial aggregation...
This study examined the characteristics of 147 PDB cases from Italy. Our data showed a reduced clinical severity with respect to other populations and provided further support importance environmental factors (rural area residence animal contact) in pathogenesis PDB. Familial aggregation was observed 15% cases.The etiology Paget's disease bone (PDB) remains unknown. Current evidence suggests that interactions among genetic or exogenous seem be necessary for expression. Major epidemiological...
Bazedoxifene for the prevention of postmenopausal osteoporosis Luigi Gennari, Daniela Merlotti, Vincenzo De Paola, Giuseppe Martini, Ranuccio NutiDepartment Internal Medicine, Endocrine-Metabolic Sciences and Biochemistry, University Siena, Policlinico Le Scotte 53100-Siena, ItalyAbstract: acetate is a novel, chemically distinct selective estrogen receptor modulator (SERM) that has been specifically developed after stringent preclinical screening in order to obtain favorable effects on...
Aminobisphosphonates actually represent the most common treatment for Paget disease of bone (PDB). In a previous study we demonstrated that either zoledronic acid (4 mg) or neridronate (200 given as single intravenous infusion showed similar short-term efficacy in achieving biochemical remission up to 90% patient nonresponders pamidronate. this compared long-term (36 months) effects same dose an (100-mg 2 consecutive days) intramuscular (25-mg injection weekly regimen 56 patients with active...
Recently ultrasound techniques have been proposed to evaluate skeletal status. Speed of sound and attenuation through the bone are properties currently used assess strength fragility. The speed in m s-1 (SOS), broadband dB MHz-1 (BUA) stiffness (S) 134 healthy females (age range 10-90 years) 100 males 10-93 was measured using Achilles scanner (Lunar Corp., Madison, WI, USA). A polynomial function applied observed data a pattern age-related BUA, SOS S changes. Peak values SOS, BUA were...
Abstract Both dual-photon absorptiometry (DPA) using 153Gd and dual-energy x-ray (DEXA) can be used for measurement of bone mineral content (BMC) density (BMD) the total skeleton its seven major regions. The short-term precision (coefficient variation, CV) DEXA total-body BMD medium (20 minute) fast (10 speeds was 0.34 0.68% in 5 normal subjects; corresponding CV osteoporotic females were 0.70 1.04%. DPA 0.82% 8 subjects 0.70% 12 patients. regional similar to fast-speed DEXA, without...
Carvedilol treatment in chronic heart failure (CHF) patients has been demonstrated to reduce mortality by improving cardiac systolic function and reducing left ventricular adverse remodeling. However, the effects of drug on (LV) filling are less studied. In this study we evaluated early long-term diastolic modifications an echo-Doppler method during carvedilol therapy with advanced CHF pseudonormal or restrictive pattern. We studied 58 severe but stable (39 class NYHA III 19 IV) having...