A5063776820- T-cell and B-cell Immunology
- Atherosclerosis and Cardiovascular Diseases
- Immune Cell Function and Interaction
- Genetics, Aging, and Longevity in Model Organisms
- Immune Response and Inflammation
- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Adipokines, Inflammation, and Metabolic Diseases
- Immunotherapy and Immune Responses
- Celiac Disease Research and Management
- Tryptophan and brain disorders
- Inflammasome and immune disorders
- Aortic aneurysm repair treatments
- Trace Elements in Health
- Lipoproteins and Cardiovascular Health
- Cell Adhesion Molecules Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- S100 Proteins and Annexins
- Aortic Disease and Treatment Approaches
- Blood Coagulation and Thrombosis Mechanisms
- Immune cells in cancer
- Diabetes and associated disorders
- Cytomegalovirus and herpesvirus research
- Microscopic Colitis
- Dietary Effects on Health
University of Palermo
2014-2024
Walter and Eliza Hall Institute of Medical Research
2023
The University of Melbourne
2023
University of Turin
2016
Magna Graecia University
2016
University of Salerno
2016
University of Naples Federico II
2016
University of Campania "Luigi Vanvitelli"
2016
University of Messina
2012
University of Udine
2012
The process of maintaining life for the individual is a constant struggle to preserve his/her integrity. This can come at price when immunity involved, namely systemic inflammation. Inflammation not per se negative phenomenon: it response immune system invasion viruses or bacteria and other pathogens. During evolution human organism was set live 40 50 years; today, however, must remain active much longer time. very long activity leads chronic inflammation that slowly but inexorably damages...
Bicuspid valve disease is associated with the development of thoracic aortic aneurysm. The molecular mechanisms underlying this association still need to be clarified. Here, we evaluated circulating levels T and B lymphocyte subsets vascular diseases in patients bicuspid or tricuspid without We unveiled that MAIT, CD4+IL−17A+, NKT cell were significantly reduced cases, when compared cases either presence absence Among valve, these cells higher those also affected by Similar data obtained...
Thoracic aortic aneurysm (TAA) is a progressive disorder involving gradual dilation of ascending and/or descending thoracic aorta with dissection or rupture as complications. It occurs sporadic defined syndromes/familial forms.Genetic, molecular and cellular mechanims TAA forms are poorly characterized known. Thus, our interest has been focused on investigating the role genetic variants transforming growth factor-β (TGF-β) pathways in risk. On other hand, no data TGF-β pathway exist until...
Ionizing radiation (IR) activates both pro-and anti-proliferative signal pathways producing an imbalance in cell fate decision. IR is able to regulate several genes and factors involved cell-cycle progression, survival and/or death, DNA repair inflammation modulating intracellular radiation-dependent response. Radiation therapy can modulate anti-tumour immune responses, modifying tumour its microenvironment. In this review, we report how could stimulate inflammatory affect via multiple...
Summary In the light of key role played by interferon (IFN)‐γ in control tuberculosis, present paper we have evaluated distribution functional +874T → A IFN‐γ single nucleotide polymorphism (SNP) Sicilian patients affected tuberculosis. Our aim was to determine whether there is an association between TT genotype, which has been suggested be linked increased production IFN‐γ, and resistance chronic DNA samples were obtained from 45 97 healthy controls. Polymorphism at +874 identified using...
The literature on immunosenescence has focused mainly T cell impairment. With the aim of gaining insight into B immunosenescence, we investigated serum immunoglobulin levels in a cohort 166 subjects (20-106 years). Serum IgG (and subclasses) were quantified by nephelometric technique, IgE CAP system fluorescence enzyme immunoassay, and IgD radial immunodiffusion (RID). There was an age-related increase IgA; significant only men, but IgG1 showed both men women, whereas IgG3 men. remain...
Chronic inflammation is a major biological mechanism underpinning ageing process and age-related diseases. Inflammation also the key response of host defense against pathogens tissue injury. Current opinion sustains that during evolution have become linked together. Thus, large array factors mechanisms to NF-κB system seem be involved in process. This concept leads us proposing inductors signaling pathway as potential biomarkers. On other hand, biomarkers, represented by indicators selected...