A5018250648- Muscle Physiology and Disorders
- Genetic Neurodegenerative Diseases
- Tissue Engineering and Regenerative Medicine
- Adipose Tissue and Metabolism
- Nutrition and Health in Aging
- Mesenchymal stem cell research
- Immune responses and vaccinations
- Neurogenetic and Muscular Disorders Research
- 3D Printing in Biomedical Research
- Viral Infections and Immunology Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Cardiac Fibrosis and Remodeling
- Bone fractures and treatments
- Long-Term Effects of COVID-19
- Mitochondrial Function and Pathology
- Muscle and Compartmental Disorders
- Exercise and Physiological Responses
- Ubiquitin and proteasome pathways
Sapienza University of Rome
2021-2025
ORCID
2023
National Cancer Institute
2023
Agostino Gemelli University Polyclinic
2023
University of Rome Tor Vergata
2020-2021
Universitat Autònoma de Barcelona
2017
Hospital de Sant Pau
2017
Article15 February 2021Open Access Transparent process Biofabricating murine and human myo-substitutes for rapid volumetric muscle loss restoration Marco Costantini Institute of Physical Chemistry, Polish Academy Sciences, Warsaw, Poland Search more papers by this author Stefano Testa Department Biology, Rome University Tor Vergata, Rome, Italy Ersilia Fornetti Claudia Fuoco Carles Sanchez Riera Minghao Nie Mechano-Informatics, Graduate School Information Science Technology, The Tokyo, Japan...
Skeletal muscle tissue is characterized by restrained self-regenerative capabilities, being ineffective in relation to trauma extension both time span (e.g., chronic diseases) and size large trauma). For these reasons, engineering and/or cellular therapies represent a valuable solution the cases where physiological healing process failed. Satellite cells, putative skeletal stem have been first explored remedy insufficient self-regeneration capacity. Nevertheless, some limitation related...
Inflammatory memory or trained immunity is a recently described process in immune and non-immune tissue resident cells, whereby previous exposure to inflammation mediators leads faster stronger responses upon secondary challenge. Whether muscle injury associated with altered subsequent by satellite cells (SCs), the stem not known. We used mouse model of repeated injury, which intramuscular cardiotoxin (CTX) injections were administered 50 days apart order allow for full recovery injured...
Chronic cardiac muscle inflammation and subsequent fibrotic tissue deposition are key features in Duchenne Muscular Dystrophy (DMD). The treatment of choice for delaying DMD progression both skeletal corticosteroids, supporting the notion that chronic heart plays a pivotal role fibrosis dysfunction. Nevertheless, considering adverse effects associated with long-term corticosteroid treatments, there is need novel anti-inflammatory therapies. In this study, we used our recently described...
<title>Abstract</title> Sarcoglycanopathies are heterogeneous proximo-distal diseases presenting severe muscle alterations. These caused by mutations in genes coding for one of the four sarcoglycan transmembrane proteins, which form complex (SGC). Little is known about different roles SGC beyond dystrophin glycoprotein (DGC) structural role. Here, we show that proteins enriched at post-synaptic membrane neuromuscular junctions (NMJs). Using a mouse model lacking beta-sarcoglycan subunit,...
SUMMARY Striated muscle is a highly organized structure composed by well-defined anatomical domains with integrated but distinct assignments. So far, the lack of direct correlation between tissue architecture and gene expression has limited our understanding how each unit responds to physio-pathologic contexts. Here, we show combined use spatially resolved transcriptomics immunofluorescence can bridge this gap enabling unbiased identification such characterization their response external...
Abstract Background Inflammatory memory or trained immunity is a recently described process in immune and non-immune tissue resident cells, whereby previous exposure to inflammation mediators leads faster stronger responses upon secondary challenge. Whether muscle injury associated with altered subsequent by satellite cells (SCs), the stem not known. Methods we used mouse model of repeated injury, which intramuscular cardiotoxin (CTX) injections were administered 50 days apart order allow...
Abstract Skeletal muscle tissue is characterized by restrained self-regenerative capabilities, being ineffective in relation to trauma extension both time span (e.g. chronic diseases) and size large trauma). For these reasons, engineering and/or cellular therapies represent a valuable solution the cases where physiological healing process failed. Satellite cells, putative skeletal stem have been first explored remedy insufficient self-regeneration capacity. Nevertheless, some limitation...