A5014095575- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Cardiac Arrest and Resuscitation
- Autophagy in Disease and Therapy
- Coronary Interventions and Diagnostics
- Gout, Hyperuricemia, Uric Acid
- Acute Kidney Injury Research
- Mitochondrial Function and Pathology
- Cardiac Imaging and Diagnostics
- Sepsis Diagnosis and Treatment
- Mechanical Circulatory Support Devices
- Acute Myocardial Infarction Research
- Potassium and Related Disorders
- Adipose Tissue and Metabolism
- Cardiac Structural Anomalies and Repair
- Renal function and acid-base balance
- Aortic Disease and Treatment Approaches
- Cardiac Valve Diseases and Treatments
- Hippo pathway signaling and YAP/TAZ
- Congenital Heart Disease Studies
- Protease and Inhibitor Mechanisms
- Endoplasmic Reticulum Stress and Disease
- ATP Synthase and ATPases Research
- Cardiovascular and Diving-Related Complications
- Hemodynamic Monitoring and Therapy
Chiba Hokusou Hospital
2016-2025
Japanese Circulation Society
2023
Society for Vascular Surgery
2023
Rutgers, The State University of New Jersey
2014-2022
Rutgers New Jersey Medical School
2016-2022
Nippon Medical School
2007-2020
Mitsukoshi Health and Welfare Foundation
2020
Tokyo Medical and Dental University
2020
Intensive Care Society
2016-2018
Kyushu University
2016
Both fusion and fission contribute to mitochondrial quality control. How unopposed affects survival of cardiomyocytes left ventricular function in the heart is poorly understood.We investigated role dynamin-related protein 1 (Drp1), a GTPase that mediates fission, mediating autophagy, function, stress resistance heart.Drp1 downregulation induced elongation, accumulation damaged mitochondria, increased apoptosis at baseline. Drp1 also suppressed autophagosome formation autophagic flux...
Background— Mitochondrial autophagy is an important mediator of mitochondrial quality control in cardiomyocytes. The occurrence and its significance during cardiac hypertrophy are not well understood. Methods Results— Mice were subjected to transverse aortic constriction (TAC) observed at multiple time points up 30 days. Cardiac developed after 5 days, the ejection fraction was reduced 14 heart failure days TAC. General upregulated between 1 12 hours TAC but downregulated below physiological...
Rationale: Diabetic patients develop cardiomyopathy characterized by hypertrophy, diastolic dysfunction, and intracellular lipid accumulation, termed lipotoxicity. hearts utilize fatty acids as a major energy source, which produces high levels of oxidative stress, thereby inducing mitochondrial dysfunction. Objective: To elucidate how function is regulated in diabetic cardiomyopathy. Methods Results: Mice were fed either normal diet or high-fat (HFD, 60 kcal % fat). Although autophagic flux...
Abstract Background Protection from lethal ventricular arrhythmias leading to sudden cardiac death (SCD) is a crucial challenge after acute myocardial infarction (AMI). Cardiac sympathetic and parasympathetic activity can be noninvasively assessed using heart rate variability (HRV) turbulence (HRT). The EMBODY trial was designed determine whether the Sodium–glucose cotransporter 2 (SGLT2) inhibitor improves nerve activity. Methods This prospective, multicenter, randomized, double-blind,...
Rationale: In Drosophila , the Hippo signaling pathway negatively regulates organ size by suppressing cell proliferation and survival through inhibition of Yorkie, a transcriptional cofactor. Yes-associated protein (YAP), mammalian homolog promotes cardiomyocyte growth in postnatal hearts. However, underlying mechanism responsible for beneficial effect YAP cardiomyocytes remains unclear. Objectives: We investigated whether miR-206, microRNA known to promote hypertrophy skeletal muscle,...
Well-controlled mitochondrial homeostasis, including a mitochondria-specific form of autophagy (hereafter referred to as mitophagy), is essential for maintaining cardiac function. The molecular mechanism mediating mitophagy during pressure overload (PO) poorly understood. We have shown previously that in the heart mediated primarily by Atg5/Atg7-independent mechanisms, Unc-51-like kinase 1 (Ulk1)-dependent alternative mitophagy, myocardial ischaemia. Here, we investigated role PO-induced hypertrophy.
Background: The relationship between acute kidney injury (AKI) in the phase of decompensated heart failure (ADHF) and patient outcome has not yet been reported. Methods Results: Data for 625 patients with ADHF admitted to intensive care unit were analyzed. No AKI occurred 281 (no AKI) during first 5 days. assigned 3 groups based on timing: present admission stable risk, injury, failure, loss, endstage (RIFLE) class (stable early AKI; n=125), stepped-up RIFLE (worsening n=49), or that after...
Background: Tolvaptan, an oral selective vasopressin 2 receptor antagonist that acts on the distal nephrons to cause a loss of electrolyte-free water, is rarely used during acute phase heart failure (AHF). Methods and Results: We investigated 183 AHF patients admitted intensive care unit administered tolvaptan (7.5mg) with continuous intravenous furosemide, then additionally at 12-h intervals until HF was compensated. When furosemide changed peroral use, administration stopped. The were...
Rationale: Obesity-associated cardiomyopathy characterized by hypertrophy and mitochondrial dysfunction. Mitochondrial quality control mechanisms, including mitophagy, are essential for the maintenance of cardiac function in obesity-associated cardiomyopathy. However, autophagic flux peaks at around 6 weeks high-fat diet (HFD) consumption declines thereafter. Objective: We investigated whether mitophagy is activated during chronic phase associated with obesity (obesity cardiomyopathy) after...
OBJECTIVE To determine if prediabetes is associated with atherosclerosis of coronary arteries, we evaluated the degree in nondiabetic, prediabetic, and diabetic patients by using angioscopy to identify plaque vulnerability based on yellow color intensity. RESEARCH DESIGN AND METHODS Sixty-seven artery disease (CAD) underwent angioscopic observation multiple main-trunk arteries. According American Diabetes Association guidelines, were divided into nondiabetic (n = 16), prediabetic 28), 23)...
<b><i>Objectives:</i></b> We sought to clarify clinical features and outcomes related calcified nodules (CN) compared with plaque rupture (PR) erosion (PE) detected by optical coherence tomography (OCT) at the culprit lesions in patients acute coronary syndrome (ACS). <b><i>Methods:</i></b> Based on OCT findings for lesion morphologies, ACS analyzable images (<i>n</i> = 362) were classified as CN, PR, PE, other....
Abstract Aims Whether or not the definition of a worsening renal function (WRF) is adequate for evaluation acute failure in patients with heart unclear. Methods and results One thousand eighty‐three were analysed. A WRF, indicated by change serum creatinine ≥0.3 mg/mL during first 5 days, occurred 360 while no‐WRF, <0.3 mg/dL, 723 patients. Acute kidney injury (AKI) upon admission was defined based on ratio value recorded to baseline placed into groups degree AKI: no‐AKI ( n = 751), Class...
Lysosomal dysfunction caused by mutations in lysosomal genes results storage disorder (LSD), characterized accumulation of damaged proteins and organelles cells functional abnormalities major organs, including the heart, skeletal muscle, liver. In LSD, autophagy is inhibited at degradation step autophagosomes observed. Enlargement left ventricle (LV) contractile were observed RagA/B cardiac-specific KO (cKO) mice, a mouse model LSD which acidification impaired irreversibly. YAP, downstream...
<title>Abstract</title> The number of patients with heart failure (HF) is increasing the aging population, shifting care from hospitals to clinics. Although predicting medium-term prognosis after discharge can enhance and reduce readmissions, yet no established model has been evaluated for both discrimination calibration. This multicenter study developed validated machine learning (ML) models—including logistic regression, random forests, extreme gradient boosting, light boosting— predict...
Coronary perforation is an undesirable complication during percutaneous coronary intervention (PCI). We reviewed the cases of overt in our institute and analyzed their clinical backgrounds, characteristics target lesion, management, outcomes. Between 1991 2005, we experienced 12 (0.35%) a total 3415 PCI procedures. The occurred use debulking devices 3 cases, immediately after stenting 2, postdilatation stent wiring cases. Restoration was attempted by long inflation balloon 7 implantation...
The relationship between the short-term prognosis of acute heart failure (AHF) and kidney injury (AKI) using risk, injury, failure, end stage (RIFLE) criteria has already been reported, however, long-term AKI not. We investigated after discharge RIFLE criteria. Five hundred patients with AHF admitted to our intensive care unit were analyzed. Patients assigned a no (n = 156), Class R (risk; n 201), I (injury; 73), or F (failure; 70) most severe classifications during hospitalization....