A5077875550- Acute Myocardial Infarction Research
- Cardiac Arrest and Resuscitation
- Heart Failure Treatment and Management
- Mechanical Circulatory Support Devices
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Cardiac Structural Anomalies and Repair
- Venous Thromboembolism Diagnosis and Management
- Aortic Disease and Treatment Approaches
- Takotsubo Cardiomyopathy and Associated Phenomena
- Cardiac Valve Diseases and Treatments
- Atrial Fibrillation Management and Outcomes
- Diabetes Treatment and Management
- Cardiac electrophysiology and arrhythmias
- Cardiac, Anesthesia and Surgical Outcomes
- Aortic aneurysm repair treatments
- Coronary Interventions and Diagnostics
- Cardiac Arrhythmias and Treatments
- Heart Rate Variability and Autonomic Control
- Hip and Femur Fractures
- Climate Change and Health Impacts
- Cardiac Health and Mental Health
- Acute Ischemic Stroke Management
- Pericarditis and Cardiac Tamponade
- Central Venous Catheters and Hemodialysis
Nippon Medical School Hospital
2016-2025
Shibuya University Network
2016-2025
Nippon Medical School
2014-2024
Tokoha Gakuen University
2014-2024
Tokyo Medical and Dental University
2024
Ministry of Health Labour and Welfare
2024
Tokyo Health Care University
2017-2023
University of Oxford
2023
Amyloidosis Foundation
2021
Research Network (United States)
2021
Abstract Introduction Fever is frequently observed in critically ill patients. An independent association of fever with increased mortality has been non-neurological patients mixed febrile etiology. The and antipyretics mortality, however, may be different between infective non-infective illness. Methods We designed a prospective observational study to investigate the use antipyretic treatments without sepsis. included 1,425 consecutive adult (without neurological injury) requiring > 48...
Abstract Background Protection from lethal ventricular arrhythmias leading to sudden cardiac death (SCD) is a crucial challenge after acute myocardial infarction (AMI). Cardiac sympathetic and parasympathetic activity can be noninvasively assessed using heart rate variability (HRV) turbulence (HRT). The EMBODY trial was designed determine whether the Sodium–glucose cotransporter 2 (SGLT2) inhibitor improves nerve activity. Methods This prospective, multicenter, randomized, double-blind,...
BACKGROUND: The absence of practice standards in vasoactive agent usage for acute decompensated heart failure has resulted significant treatment variability across hospitals, potentially affecting patient outcomes. This study aimed to assess temporal trends and institutional differences vasodilator inotrope/vasopressor utilization among patients with failure, considering their clinical phenotypes. METHODS: Data were extracted from a government-funded multicenter registry covering the Tokyo...
The clinical features of gender differences in takotsubo cardiomyopathy (TC) remain to be determined. aim this study was evaluate the characteristics male and female patients with TC.We obtained information 368 diagnosed TC (84 male, 284 female) from Tokyo CCU Network database collected 1 January 2010 31 December 2012; is comprised 71 cardiovascular centers (Japan) metropolitan area. We attempted characterize during hospitalization, comparing TC.There were no significant apical ballooning...
Limited data exists on ST-segment elevation myocardial infarction (STEMI) and non-STEMI (NSTEMI) managed by a well-organized cardiac care network in metropolitan area. We analyzed the Tokyo CCU database 2009-2010. Of 4329 acute (AMI) patients including STEMI (n = 3202) NSTEMI 1127), percutaneous coronary intervention (PCI) was performed 88.8 % of 70.4 patients. Mean onset-to-door door-to-balloon times were shorter than those (167 vs 233 60 145 min, respectively, p < 0.001). Coronary artery...
Abstract Cardiogenic shock is a complex and diverse pathological condition characterized by reduced myocardial contractility. The goal of treatment cardiogenic to improve abnormal hemodynamics maintain adequate tissue perfusion in organs. If hypotension insufficient persist despite initial therapy, temporary mechanical circulatory support (t-MCS) should be initiated. This decade sees the beginning new era management using t-MCS through accumulated experience with use intra-aortic balloon...
Background Contrast-induced nephropathy (CIN) frequently complicates cardiac catheterization, so the objectives of present study were to investigate usefulness cystatin C before catheterization and establish a cut-off level for CIN, examine changes in several other markers patients with without CIN. Methods Results Prospective consecutive 87 who underwent elective catheterization: moderate renal disease defined as glomerular filtration rate 30-59 ml · min-1 ·1.73 mm-2; creatinine (Cr),...
When pulmonary embolism (PE) develops, circulatory collapse and hypoxia are caused at the same time. The rapid proper use of extracorporeal life support (ECLS) can improve mortality rate patients with collapsed massive PE. No study has examined influence treatment that involved adding catheter based-intervention to ECLS Thirty-five PE were examined, 10 these placed on ECLS. Eight for female, median age was 61 years. Seven had in-hospital onset 3 out-of-hospital Their underlying conditions a...
Background A rapid laboratory test for diagnosis of acute aortic dissection (AAD) has not been available. We performed this prospective study to determine the utility a bedside D-dimer (DD) assay detection AAD. Methods and Results Patients with suspected AAD were recruited their DD levels measured by assay. They divided into 2 groups according enhanced computed tomography findings: an group (n=30) non-AAD (n=48). The median level was higher in (1.80 μg/ml) than (0.42 (p=0.000). showed 100%...
Temporal trends in the incidence and mortality of acute myocardial infarction (AMI) have not been fully clarified Japan.
Background The association between female sex and poor outcomes following surgery for type A acute aortic dissection has been reported; however, sex‐related differences in clinical features in‐hospital of B dissection, including classic intramural hematoma, remain to be elucidated. Methods Results We studied 2372 patients with who were enrolled the Tokyo Acute Aortic Super‐Network Registry. There fewer older women than men (median age [interquartile range]: 76 years [66–84 years], n=695...
The relationship between Body Mass Index (BMI) and acute heart failure (HF) remains ill-defined. This study aimed to compare the influence of BMI on in-hospital mortality patients with HF preserved ejection fraction (HFpEF) those reduced (HFrEF) examine specific phenotypes HFpEF/HFrEF according BMI. multicenter retrospective included 5313 6332 consecutive HFpEF HFrEF, respectively. Low, normal, high BMIs were defined as <18.5, 18.5 ≤BMI <25.0, ≥25.0, Overweight/obesity was ≥25.0....
Cardiovascular emergencies often require intensive care unit (ICU) management, but there is limited data comparing outcomes based on the admission ward. We analyzed from Japanese Registry of All Cardiac and Vascular Diseases Diagnosis Procedure Combination (JROAD-DPC) database (2016-2020) for 715,054 patients (mean age, 75.4±14.2 years, 58.4% male) admitted with acute myocardial infarction (N=175,974), unstable angina (N=45,308), heart failure (N=179,871), aortic dissection (N=58,597),...
Coronary perforation is an undesirable complication during percutaneous coronary intervention (PCI). We reviewed the cases of overt in our institute and analyzed their clinical backgrounds, characteristics target lesion, management, outcomes. Between 1991 2005, we experienced 12 (0.35%) a total 3415 PCI procedures. The occurred use debulking devices 3 cases, immediately after stenting 2, postdilatation stent wiring cases. Restoration was attempted by long inflation balloon 7 implantation...
The mortality rate of acute myocardial infarction (AMI) has improved dramatically because reperfusion therapy during the last 40 years; however, recent temporal trends for AMI have not been fully clarified in Japan.The purpose this study was to elucidate temporary trend in-hospital and treatment decade Tokyo Metropolitan area.We enrolled 30,553 patients from Cardiovascular Care Unit Network Registry, diagnosed with 2007 2016, as part an ongoing, multicenter, cohort study. We analyzed basic...
High-Sensitivity cTn to Rule-In and Rule-Out NSTEMI ••••
Protection from lethal ventricular arrhythmias leading to sudden cardiac death is one of the most important problems after myocardial infarction. Cardiac sympathetic hyperactivity related poor prognosis and fatal can be non-invasively assessed with heart rate variability, turbulence, T-wave alternans, late potentials, 123I-meta-iodobenzylguanide (123I-MIBG) scintigraphy. Sodium glucose cotransporter 2 (SGLT2) inhibitors potentially reduce nervous system activity that augmented in part due...
We investigated the various pre- and postoperative complications related to early (30-day) mortality after open surgery for acute type A aortic dissection.Data from Tokyo Acute Aortic Super-network database spanning January 2015 December 2017 were retrospectively reviewed. Pre- factors assessed in 1504 of 2058 (73.0%) consecutive patients [age: 66.6 (SD: 13.5) years, male: 52.9%] who underwent dissection repair.The rate following surgical repair was 8.9%. According multivariable analysis,...