A5035959471- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Acute Myocardial Infarction Research
- Cerebrovascular and Carotid Artery Diseases
- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Aortic Thrombus and Embolism
- Diabetes Treatment and Management
- Oral microbiology and periodontitis research
- Cardiac Valve Diseases and Treatments
- Dental Health and Care Utilization
- Atrial Fibrillation Management and Outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- Aortic aneurysm repair treatments
- Lipoproteins and Cardiovascular Health
- Cardiovascular Disease and Adiposity
- Cardiac pacing and defibrillation studies
- Cardiovascular Health and Disease Prevention
- Cardiac Arrest and Resuscitation
- Retinal Development and Disorders
- Infective Endocarditis Diagnosis and Management
- Cardiac tumors and thrombi
- Liver Disease Diagnosis and Treatment
Nihon University
2016-2025
Shibuya University Network
2020-2025
Nihon University Itabashi Hospital
2021-2024
Nihon Kohden (Japan)
2024
Medtronic (Japan)
2024
Japan Lifeline (Japan)
2024
Abbott (Japan)
2024
The University of Tokyo
2022
Social Insurance Yokohama Central Hospital
2019
Advanced Imaging Research (United States)
2018
BACKGROUND: The absence of practice standards in vasoactive agent usage for acute decompensated heart failure has resulted significant treatment variability across hospitals, potentially affecting patient outcomes. This study aimed to assess temporal trends and institutional differences vasodilator inotrope/vasopressor utilization among patients with failure, considering their clinical phenotypes. METHODS: Data were extracted from a government-funded multicenter registry covering the Tokyo...
The combination of antiplatelet and antithrombotic drugs increases the risk bleeding in patients with atrial fibrillation after coronary drug-eluting stent (DES) implantation. However, appropriateness direct-acting oral anticoagulant (DOAC) monotherapy at time implantation remains uncertain. objective this study was to evaluate safety efficacy DOAC monotherapy, specifically using factor Xa inhibitors such as edoxaban, a low-density lipoprotein receptor knockout (LDL-R-/-) miniature pig model...
The relationship between Body Mass Index (BMI) and acute heart failure (HF) remains ill-defined. This study aimed to compare the influence of BMI on in-hospital mortality patients with HF preserved ejection fraction (HFpEF) those reduced (HFrEF) examine specific phenotypes HFpEF/HFrEF according BMI. multicenter retrospective included 5313 6332 consecutive HFpEF HFrEF, respectively. Low, normal, high BMIs were defined as <18.5, 18.5 ≤BMI <25.0, ≥25.0, Overweight/obesity was ≥25.0....
Background Late adverse myocardial remodeling after ST elevation infarction (STEMI) is strongly associated with cardiac death. Global Longitudinal strain (GLS) and circumferential diastolic rate (CDSR) derived cardiovascular magnetic resonance imaging (CMRI) a powerful predictor of late remodeling. However, the Impella's effects on CMRI STEMI are not fully understood.
Oxidative stress is involved in the initiation and progression of atherosclerosis, hyperglycemia known to increase oxidative stress, which injures endothelium accelerates atherosclerosis. To clarify relation between diabetes mellitus (DM), acute myocardial infarction (AMI), we evaluated compared time-specific after AMI patients with without DM by simple measurement derivatives reactive oxygen metabolites (d-ROMs) levels as indices species production.Sixty-eight were enrolled (34 non-DM 34...
Wall shear stress (WSS) has been considered a major determinant of aortic atherosclerosis. Recently, non-obstructive general angioscopy (NOGA) was developed to visualize various atherosclerotic pathologies, including in vivo ruptured plaque (RP) the aorta. However, relationship between RP and WSS distribution within wall is unclear. This study aimed investigate NOGA-derived stereographic by computational fluid dynamics (CFD) modeling using three-dimensional computed tomography (3D-CT)...
There are a few Japanese data regarding the incidence and outcomes of acute myocardial infarction (AMI) after coronavirus disease 2019 (COVID-19) outbreak. We retrospectively reviewed AMI patients admitted to Nihon University Itabashi Hospital COVID-19 outbreak in 2020 (COVID-19 period) same period from 2017 (control period). The patients' characteristics, time course admission, diagnosis, treatment AMI, 30-day mortality were compared between two period-groups for both ST-segment elevation...
Abstract Aims Sodium‐glucose co‐transporter 2 (SGLT2) inhibitors have shown potential therapeutic benefits in heart failure (HF). However, data on their real‐world usage and acute decompensated (ADHF) are limited. Methods results We conducted a post hoc analysis of from 1108 patients with ADHF admitted to Nihon University Itabashi Hospital (Tokyo, Japan) between 2018 2022. Patients were divided into two groups based the prescription SGLT2 during hospitalization: an inhibitor group (SGLT2i...
Abstract Background Hyperglycemia, a risk factor for development of cardiovascular disease, causes endothelial dysfunction. Alpha-glucosidase inhibitors (α-GIs) improve postprandial hyperglycemia (PPHG) and may have favorable effects on associated disease. Effects α-GIs in patients with acute coronary syndrome (ACS) PPHG remain unclear; thus, we assessed the effect α-GI miglitol function such by digital reactive hyperemia peripheral arterial tonometry (RH-PAT). Methods Fifty-four ACS who...
Objective Sodium-glucose co-transporter-2 inhibitors (SGLT2is), such as dapagliflozin, have a diuretic effect, and their early initiation to treat acute heart failure (AHF) may improve outcomes; however, the significance of timing starting dapagliflozin after hospital admission remains unclear. Methods We performed post hoc analysis prospective, observational registry. Participants were divided into (E) group late (L) using median time (6 days) cut-off. evaluated relationship between patient...
Abstract Background and aims Macrophage accumulation in arteriosclerotic plaque of coronary arteries is involved destabilization. Atherosclerosis has been known to be progressive patients with type 2 diabetes mellitus (DM). This study compared the features 3-dimensional (3D) spatial distribution macrophage within artery wall between acute syndrome (ACS) DM (n = 20) those without (non-DM, n by using intravascular ultrasound (IVUS) optical coherence tomography (OCT). Methods The OCT-derived...
Smaller low-density lipoprotein (LDL) particle size has been suggested to result in the development of endothelial dysfunction, atherosclerosis, and in-stent restenosis (ISR); however, little is known regarding impact LDL on neointima formation leading ISR after everolimus-eluting stent (EES) implantation.In this study, we have included 100 patients examine relationship between an LDL-C/apolipoprotein B (Apo B) ≤ 1.2, reportedly representing size, neointimal characteristics using optical...
Abstract Background The clinical efficacy of the Impella for high-risk percutaneous coronary intervention (PCI) and cardiogenic shock remains under debate. We thus sought to investigate protective effects on heart with Impella’s early use pre-PCI using cardiac magnetic resonance imaging (CMRI). Methods retrospectively evaluated difference in subacute phase CMR results (19 ± 9 days after admission) between patients undergoing an (n = 7) or not (non-Impella group: n 18 [12 intra-aortic balloon...
Heart failure with preserved ejection fraction (HFpEF) renal dysfunction (RD) is considered to be a specific phenotype of HFpEF. This study aimed compare the clinical characteristics and prognostic factors for in-hospital mortality between HFpEF-diagnosed patients without RD.
The Model for End-stage Liver Disease eXcluding International normalized ratio (MELD-XI) is an established scoring system that reflects hepatorenal function. However, little known about the prognostic value of changes in MELD-XI score during hospitalization acute decompensated heart failure (ADHF).We prospectively analysed 536 patients admitted ADHF between January 2018 and December 2019. In MELD-XI, 9.44 lowest possible considered to be normal, values above are classified as high. We...
Abstract Objective The aim of this study was to compare how prasugrel and clopidogrel affect platelet aggregation reactivity, cardiac enzyme release, remodeling, the formation in‐stent thrombi after primary percutaneous coronary intervention (PCI). Background advantages using over in injury following acute syndrome (ACS) remain unclear. Methods A total 78 ACS patients were randomly allocated into (300 mg loading/75 maintenance) or (20 loading/3.75 treatment groups, followed by undergoing...
Abstract Atrial fibrillation (AF) is a progressive disease that starts with structural or functional changes in the left atrium and ventricle, evolves from paroxysmal toward sustained forms. Early detection of ventricle stage could be useful for identifying higher risk progression to persistent AF future cardio-cerebrovascular events. The aim this study was test hypothesis feature tracking (FT) atrial (LA) strain ventricular (LV) extracellular volume fraction (ECV) derived cardiovascular...
The absence of high quality, large-scale data that indicates definitive mortality benefits does not allow for firm conclusions on the role intravenous vasodilators in acute heart failure. We aimed to investigate associations between and clinical outcomes failure patients, with a specific focus patient profiles type vasodilators.Data 26,212 consecutive patients urgently hospitalised primary diagnosis 2009 2015 were extracted from government-funded multicentre registration system. Propensity...
Congestive splenomegaly is a classic sign of organ congestion in acute decompensated heart failure (ADHF). Shear wave elastography (SWE) allows the measurement spleen stiffness (SS). We hypothesized that SS could quantify severity splenic and predict adverse events ADHF.This study included two cohorts: haemodynamic cohort (62 HF patients) an outcome (115 ADHF patients). was measured by two-dimensional SWE on same day right catheterization cohort. Right atrial pressure (RAP) independently...