Alberto Chiti
A5088791721- Acute Ischemic Stroke Management
- Atrial Fibrillation Management and Outcomes
- Venous Thromboembolism Diagnosis and Management
- Cerebrovascular and Carotid Artery Diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Migraine and Headache Studies
- Neurological Disorders and Treatments
- Dementia and Cognitive Impairment Research
- Cardiac Imaging and Diagnostics
- Neurological Complications and Syndromes
- Stroke Rehabilitation and Recovery
- Cerebrovascular and genetic disorders
- Cerebral Venous Sinus Thrombosis
- Cardiac Valve Diseases and Treatments
- Cardiac Arrhythmias and Treatments
- Neurological Disease Mechanisms and Treatments
- Lipoproteins and Cardiovascular Health
- Neurosurgical Procedures and Complications
- Aortic Disease and Treatment Approaches
- Spinal Hematomas and Complications
- Lysosomal Storage Disorders Research
- Infective Endocarditis Diagnosis and Management
Nuovo Ospedale di Prato
2020-2024
Accademia di Belle Arti di Carrara
2024
Ospedale Vito Fazzi
2024
Azienda Ospedaliera Universitaria Pisana
2011-2021
University of Pisa
2009-2021
Thales (Portugal)
2020-2021
CTO Andrea Alesini
2008-2020
Azienda Ospedaliera Sant'Andrea
2014-2019
University of Pavia
2014-2018
University of Brescia
2014-2018
Background and Purpose— The best time for administering anticoagulation therapy in acute cardioembolic stroke remains unclear. This prospective cohort study of patients with atrial fibrillation, evaluated (1) the risk recurrent ischemic event severe bleeding; (2) factors recurrence (3) risks bleeding associated anticoagulant its starting after stroke. Methods— primary outcome this multicenter was composite stroke, transient attack, symptomatic systemic embolism, cerebral major extracranial...
Background The optimal timing to administer non–vitamin K oral anticoagulants ( NOAC s) in patients with acute ischemic stroke and atrial fibrillation is unclear. This prospective observational multicenter study evaluated the rates of early recurrence major bleeding (within 90 days) their who received s for secondary prevention. Methods Results Recurrence was defined as composite stroke, transient attack, symptomatic systemic embolism, cerebral extracranial bleeding. For analysis, 1127 were...
Background— Data on long-term risk and predictors of recurrent thrombotic events after ischemic stroke at a young age are limited. Methods Results— We followed 1867 patients with first-ever who were 18 to 45 years (mean age, 36.8±7.1 years; women, 49.0%), as part the Italian Project Stroke in Young Adults (IPSYS). Median follow-up was 40 months (25th 75th percentile, 53). The primary end point composite stroke, transient attack, myocardial infarction, or other arterial events. One hundred...
Background and Purpose- Despite treatment with oral anticoagulants, patients nonvalvular atrial fibrillation (AF) may experience ischemic cerebrovascular events. The aims of this case-control study in AF were to identify the pathogenesis risk factors for events occurring during non-vitamin K antagonist anticoagulants (NOACs) therapy stroke prevention. Methods- Cases consecutive who had acute NOAC treatment. Controls did not have NOACs Results- Overall, 713 cases (641 strokes 72 transient...
In patients with atrial fibrillation who suffered an ischemic stroke while on treatment nonvitamin K antagonist oral anticoagulants, rates and determinants of recurrent events major bleedings remain uncertain.This prospective multicenter observational study aimed to estimate the bleeding their in follow-up consecutive acute cerebrovascular event anticoagulant treatment. Afterwards, we compared estimated risks between whom therapy was changed those continued original treatment.After a mean...
Background and Purpose— The beneficial effect of intravenous thrombolytic therapy in patients with acute ischemic stroke attributable to internal carotid artery (ICA) occlusion remains unclear. aim this study was evaluate the efficacy safety recombinant tissue-type plasminogen activator these patients. Methods— ICARO a case-control multicenter on prospectively collected data. Patients ICA treated within 4.5 hours from symptom onset (cases) were compared matched not (controls). Cases controls...
Background In patients with acute ischemic stroke and atrial fibrillation, early anticoagulation prevents recurrence but the risk of hemorrhagic transformation ( HT ). The aims this study were to evaluate in consecutive fibrillation (1) incidence HT, (2) time initiation , (3) association recurrences, (4) clinical outcome at 90 days. Methods Results was diagnosed by a second brain computed tomographic scan performed 24 72 hours after onset. recurrences as well mortality or disability...
<h3>Importance</h3> Although sparse observational studies have suggested a link between migraine and cervical artery dissection (CEAD), any association the 2 disorders is still unconfirmed. This lack of definitive conclusion might implications in understanding pathogenesis both conditions complex relationship ischemic stroke (IS). <h3>Objective</h3> To investigate whether history its subtypes associated with occurrence CEAD. <h3>Design, Setting, Participants</h3> A prospective cohort study...
Introduction: The efficacy and safety of statins for secondary prevention in patients who have experienced a cardioembolic stroke are not well-defined. However, previous observational data reported hyperlipidemia as risk factor both ischemic bleeding complications with AF stroke. Based on these premises, we conducted sub-analysis the RAF RAF-NOAC studies to evaluate acute AF. Materials methods: We combined patient from studies, prospective across Stroke Units Europe, United States, Asia...
ABSTRACT Background and Aim According to randomized controlled trials (RCTs), dual antiplatelet therapy (DAPT) is more effective for secondary prevention of ischemic events attributable large artery atherosclerosis (LAA) than other mechanisms. We investigated whether real‐world application may impact DAPT effectiveness safety in the REAl‐life study on short‐term Dual Antiplatelet treatment Patients with stroke or Transient attack (READAPT, NCT05476081). Methods READAPT was an observational...
Introduction: Patients with ischemic stroke or transient attack (TIA) and cancer face unique risks of recurrent events bleeding. It is unclear whether this increased risk present even in patients minor receiving dual antiplatelet therapy (DAPT). This study aimed to evaluate the impact on short-term outcomes after DAPT non-cardioembolic high-risk TIA. methods: was a secondary analysis prospective multicentric READAPT (NCT05476081), including (NIHSS ⩽ 5) TIA (ABCD2 ⩾4) who initiated within 48...
Background: Elevated baseline systolic blood pressure (SBP) was associated with poor outcomes following dual antiplatelet therapy (DAPT) in patients non-cardioembolic minor ischemic stroke (MIS) or high-risk transient attack (TIA) clinical trials. Objectives: We aimed to assess the impact of admission SBP on short-term after DAPT MIS TIA. Methods: performed an inverse probability weighted (IPW) analysis from a prospective multicentric real-world study (READAPT) including (National Institute...
Abstract Introduction Mild cognitive impairment (MCI) prodromic of vascular dementia is expected to have a multidomain profile. Methods In sample cerebral small vessel disease (SVD) patients, we assessed MCI subtypes distributions according different operationalization Winblad criteria and compared the neuroimaging features single versus MCI. We applied three diagnostic scenarios in which cutoffs for objective number considered neuropsychological tests varied. Results Passing from liberal...
<h3>Objective</h3> Although a concern exists that 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) might increase the risk of intracerebral haemorrhage (ICH), contribution these agents to relationship between serum cholesterol and disease occurrence has been poorly investigated. <h3>Methods</h3> We compared consecutive patients having ICH with age sex-matched stroke-free control subjects in case–control analysis, as part Multicenter Study on Cerebral Haemorrhage Italy...
This study was designed to derive and validate a score predict early ischemic events major bleedings after an acute stroke in patients with atrial fibrillation.The derivation cohort consisted of 854 fibrillation included prospective series between January 2012 March 2014. Older age (hazard ratio 1.06 for each additional year; 95% confidence interval, 1.00-1.11) severe enlargement ratio, 2.05; 1.08-2.87) were predictors outcome (stroke, transient attack, systemic embolism) at 90 days from...
Background and Purpose— Bridging therapy with low-molecular-weight heparin reportedly leads to a worse outcome for acute cardioembolic stroke patients because of higher incidence intracerebral bleeding. However, this practice is common in clinical settings. This observational study aimed compare (1) the profiles receiving not bridging therapy, (2) overall group outcomes, (3) outcomes according type anticoagulant prescribed. Methods— We analyzed data from prospective RAF RAF-NOACs studies....
Introduction To describe clinical, neuroimaging, and laboratory features of a large cohort Italian patients with reversible cerebral vasoconstriction syndrome. Methods In the setting multicenter Project on Stroke at Young Age (IPSYS), we retrospectively enrolled diagnosis definite syndrome according to International Classification Headache Disorders (ICHD)-3 beta criteria (6.7.3 attributed syndrome, imaging-proven). Clinical manifestations, treatment, clinical outcomes were evaluated in all...
Dementia is one of the most disabling conditions. Alzheimer’s disease and vascular dementia (VaD) are frequent causes. Subcortical VaD consequent to deep-brain small vessel (SVD) form VaD. Its pathological hallmarks ischemic white matter changes lacunar infarcts. Degenerative often coexist, but mechanisms interaction incompletely understood. The term mild cognitive impairment defines a transitional state between normal ageing dementia. Pre-dementia stages also acknowledged (vascular...
<h3>Objective</h3> To investigate the role of alcohol as a causal factor for intracerebral hemorrhage (ICH) and whether its effects might vary according to pathogenic mechanisms underlying cerebral bleeding. <h3>Methods</h3> We performed case-control analysis, comparing cohort consecutive white patients with ICH aged 55 years older group age- sex-matched stroke-free controls, enrolled in setting Multicenter Study on Cerebral Haemorrhage Italy (MUCH-Italy) between 2002 2014. Participants were...