A5030535929- Venous Thromboembolism Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Acute Myocardial Infarction Research
- Acute Ischemic Stroke Management
- Sepsis Diagnosis and Treatment
- Emergency and Acute Care Studies
- Ultrasound in Clinical Applications
- Cardiac Imaging and Diagnostics
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Rheumatoid Arthritis Research and Therapies
- Antiplatelet Therapy and Cardiovascular Diseases
- Infective Endocarditis Diagnosis and Management
- S100 Proteins and Annexins
- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Reliability and Agreement in Measurement
- Intracerebral and Subarachnoid Hemorrhage Research
- Radiation Dose and Imaging
- Rough Sets and Fuzzy Logic
- Clusterin in disease pathology
- Traditional Chinese Medicine Studies
- Bioinformatics and Genomic Networks
- Cardiac Valve Diseases and Treatments
- Cardiovascular Issues in Pregnancy
- Dermatological and Skeletal Disorders
University of Perugia
2024
Ospedali Riuniti di Ancona
1993-2023
Azienda Ospedaliero Universitaria Ospedali Riuniti
2015-2022
Ospedali Riuniti Umberto I
2016-2018
Canadian Respiratory Research Network
2016
Collagen Medical (United States)
1993
Vita-Salute San Raffaele University
1989-1990
The European Society of Cardiology (ESC) has proposed an updated risk stratification model for death in patients with acute pulmonary embolism based on clinical scores (Pulmonary Embolism Severity Index (PESI) or simplified PESI (sPESI)), right ventricle dysfunction (RVD) and elevated serum troponin (2014 ESC model).We assessed the ability 2014 to predict 30-day after embolism. Consecutive symptomatic, confirmed included prospective cohorts were merged a collaborative database. Patients' was...
Abstract Aims To investigate the efficacy and safety of early transition from hospital to ambulatory treatment in low-risk acute PE, using oral factor Xa inhibitor rivaroxaban. Methods results We conducted a prospective multicentre single-arm investigator initiated academically sponsored management trial patients with PE (EudraCT Identifier 2013-001657-28). Eligibility criteria included absence (i) haemodynamic instability, (ii) right ventricular dysfunction or intracardiac thrombi, (iii)...
Background Candidemia is a life-threatening fungal infection and it can affect patients of all ages. Characterization candidemia in the elderly lacking. Methods We performed retrospective study adults (≥ 18 years) with diagnosed our center 2010–2015. Demographics, comorbidities, clinical microbiologic characteristics, antifungal treatment outcome were compared between older (≤65 younger (>65 patients. Results Among 302 identified during period, 188 (62%) belonged to group. Comorbidities...
Hypernetworks are based on topological simplicial complexes and generalize the concept of two-body relation to many-body relation. Furthermore, provide a significant generalization network theory, enabling integration relational structure, logic analytic dynamics. A pulmonary embolism is blockage main artery lung or one its branches, frequently fatal. Our study uses data 28 diagnostic features 1427 people considered be at risk enrolled in Department Internal Subintensive Medicine an Italian...
The optimal strategy for identification of hemodynamically stable patients with acute pulmonary embolism (PE) at risk death and clinical deterioration remains undefined.
Data in literature indicate that patients suffering a minor head injury (MHI), biomarkers serum levels could be effective to predict the absence of intracranial (ICI) on CT scan. Use these case taking oral anticoagulants who experience MHI is very limited. We investigated as predictors ICI anticoagulated managed an ED.
Critically ill patients affected by atrial fibrillation are at high risk of adverse events: however, the actual stratification models for haemorrhagic and thrombotic events not validated in a critical care setting. With this paper we aimed to identify, adopting topological data analysis, factors therapeutic failure (in-hospital death or intensive unit transfer), in-hospital occurrence stroke/TIA major bleeding cohort critically with pre-existing admitted stepdown unit; engineer newer...
The clinical benefit of anticoagulant treatment for various indications is offset by the risk bleeding. impact bleeding related to vitamin K antagonist (VKA) use, in terms patients’ discomfort or temporary disability and both medical socio-economic resources not negligible1–4. However, majority studies have focused on major bleeding, used obsolete definitions distinguished between clinically relevant non-major (CRNMB) minor events2,3. International Society Thrombosis Haemostasis provided a...
Controversies on sub-populations most sensitive to therapy and the best timing of starting treatment still surround use immunomodulatory drugs in COVID-19.We designed a multicentre open-label randomised controlled trial test effect prompt adding tofacitinib standard for hospitalised patients affected by mild/moderate COVID-19 pneumonitis.Patients admitted three Italian hospitals pneumonitis not requiring mechanical ventilation were receive alone or (10 mg/bid) 2 weeks, within first 24 h from...
Abstract Procalcitonin (PCT) is a marker of bacterial infection. Its prognostic role in the critically-ill patient, however, still object debate. Aim this study was to evaluate capacity admission PCT (aPCT) assessing prognosis patient regardless presence A single-cohort, single-center retrospective performed evaluating patients admitted stepdown care unit. Age, sex, Simplified Acute Physiology Score II (SAPS-II), shock, troponin-I, aPCT, serum creatinine, cultures and clinical endpoints...
We report the case of a 63-year-old male patient admitted to our emergency department for dyspnoea, peripheral oedema, severe diarrhoea and asthenia. History revealed Crohn’s disease (CD) submitted several intestinal surgical resections in previous years. He recently started treatment with adalimumab control CD. Laboratory tests at admission haemolytic anaemia thrombocytopaenia. Haptoglobin levels were low, schistocyte count was markedly increased. In suspect thrombotic microangiopathy, he...
Abstract Background Limited data are available on the clinical course of patients with history atrial fibrillation (AF) when admitted in an intensive care environment. We aimed to describe occurrence major adverse events AF a stepdown unit (SDU) and analyse factors associated outcomes, impact dicumarolic oral anticoagulant (OAC) therapy performance risk scores this setting. Materials methods Single‐centre, observational retrospective analysis population subjects SDU. Therapeutic failure...
Early diagnosis and treatment of deep vein thrombosis (DVT) is a main issue in the Emergency setting. With aim assisting clinicians subsequent management DVT Departments, Nominal Group Technique (NGT) study was conducted. A panel 5 Italian experts developed 21 consensus statements based on available evidence their clinical experience. The agreed may assist applying results studies experience to routine care settings, providing guidance all aspects risk assessment, prophylaxis, early appropriate EDs.
Post-discharge prophylaxis for venous thromboembolism (VTE) is a challenging issue in patients hospitalised Internal Medicine Units (IMUs). The aim of this study was to evaluate the frequency and factors associated with post-discharge VTE IMUs. Multi-centre, retrospective including consecutive who were admitted any cause discharged from an IMU. Overall, 3,740 (mean age 74.1 ± 15.7 years) included at 38 IMUs Italy. At discharge, percentage receiving pharmacological thromboprophylaxis 16.0%...
Pulmonary Embolism (PE) is a common and potentially lethal condition. Most patients die within the first few hours from event. Despite diagnostic advances, delays underdiagnosis in PE are common.To increase performance PE, current work-up of with suspected acute pulmonary embolism usually starts assessment clinical pretest probability using plasma d-Dimer measurement prediction rules. The most validated widely used decision rules Wells Geneva Revised scores. We aimed to develop new rule...