A5049499149- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Sleep and Wakefulness Research
- Neurosurgical Procedures and Complications
- Hernia repair and management
- Cerebrospinal fluid and hydrocephalus
- Nerve Injury and Rehabilitation
- COVID-19 and healthcare impacts
- Venous Thromboembolism Diagnosis and Management
- Long-Term Effects of COVID-19
- Spinal Dysraphism and Malformations
- Head and Neck Surgical Oncology
- Diagnosis and Treatment of Venous Diseases
- Climate Change and Health Impacts
- Peripheral Nerve Disorders
- Pelvic and Acetabular Injuries
- Spine and Intervertebral Disc Pathology
- Pharmacological Receptor Mechanisms and Effects
- Fetal and Pediatric Neurological Disorders
- Prion Diseases and Protein Misfolding
- Minimally Invasive Surgical Techniques
- Neurological Complications and Syndromes
- Dermatological diseases and infestations
- Voice and Speech Disorders
- Hallucinations in medical conditions
Mater Misericordiae Hospital
2025
Neuroscience Research Australia
2013-2024
Fundação Oswaldo Cruz
2023
Universidade Federal do Rio de Janeiro
2023
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2023
Universidade de São Paulo
2023
Universidade Federal do Amazonas
2023
Boston Medical Center
2021-2022
Boston University
2021-2022
Grady Memorial Hospital
2021
To determine the effects of nonbenzodiazepine sedative zopiclone on threshold to arousal with increasing respiratory effort and genioglossus muscle activity examine potential physiological factors mediating disparate obstructive sleep apnea (OSA) severity between patients.Twelve patients OSA (apnea-hypopnea index = 41 ± 8 events/h) were studied during 2 single night studies conducted approximately 1 w apart after receiving 7.5 mg or placebo according a double-blind, placebo-controlled,...
<h3>Background and Objectives</h3> Declines in stroke admission, IV thrombolysis (IVT), mechanical thrombectomy volumes were reported during the first wave of COVID-19 pandemic. There is a paucity data on longer-term effect pandemic over course year through second We sought to measure admissions, intracranial hemorrhage (ICH), IVT, 1-year period at onset (March 1, 2020, February 28, 2021) compared with immediately preceding 2019, 29, 2020). <h3>Methods</h3> conducted longitudinal...
Background A broad range of inflammatory and neurodegenerative conditions manifest with progressive cognitive behavioural changes. diagnostic challenge is the differentiation limbic encephalitis (LE) from Creutzfeldt-Jakob disease (CJD). LE CJD are distinct neurological variations in their clinical course, overlapping presentations. can be subdivided into autoimmune paraneoplastic non-paraneoplastic subtypes, under umbrella LE. most prevalent form human prion subtype sporadic (sCJD) common....
Normal pressure hydrocephalus (NPH), described by Hakim and Adams in 1965, is characterized gait apraxia, urinary incontinence, dementia. It associated with normal cerebrospinal fluid (CSF) ventricular dilation that cannot be attributed to cerebral atrophy.To evaluate characteristics patients idiopathic NPH investigate the effect of CSF tap test (CSF-TT) on gait.Twenty-five diagnosed probable were submitted CSF-TT. The procedure aimed achieve changes parameters.Fifteen parameters assessed...
Accidental opioid-related deaths are increasing. These often occur during sleep. Opioids such as morphine may worsen obstructive sleep apnoea (OSA). Thus, people with OSA be at greater risk of harm from morphine. Possible mechanisms include respiratory depression and reductions in drive to the pharyngeal muscles increase upper airway collapsibility. However, effects on four key phenotypic causes (upper collapsibility (pharyngeal critical closure pressure; P crit ), muscle responsiveness,...
JUSTIFICATIVA E OBJETIVOS: Devido à finalidade do ambulatório e os fármacos utilizados rotineiramente, o objetivo deste estudo foi rever atualizar conhecimentos sobre receptores opioides como complemento de após palestra apresentada aos integrantes da equipe. CONTEÚDO: Foram revisados desde aspectos históricos até mais recentes opioides, descritos seus subtipos mecanismos ação. Para tal, foram consultadas referências indexadas pelo Pubmed. CONCLUSÃO: Com dados presentes na literatura atual,...
Abstract Background and objective The management of chronic refractory breathlessness is one the indications for regular low‐dose (≤30 mg/24 h) oral sustained release morphine. Morphine may disrupt sleep in some conditions improve quality others. This study aimed to determine any signal regular, morphine on perceived disruption due quality. Methods a secondary analysis data from 38 participants with (30 male; 33 COPD ) aged 76 ± 0.9 years who completed double‐blind, randomized,...
MD, Head of the Unit Endovascular Neurosurgery at Hospital de Base Sao Jose do Rio Preto, SP, Brazil. Received 25 September 2007, received in final form 14 January 2008. Accepted February 2008.Dr. Zeferino Demartini Jr – / Unidade Neurocirurgia - Avenida Brig. Faria Lima 5544 15090-000 Preto SP Brasil. E-mail: demartini9@yahoo.com
Purpose: Pre-operative botulinum toxin A (BTA) injection of the lateral obliques aims to facilitate closure large ventral hernia defects and decrease risk repair breakdown during critical healing phase. The exact duration post-operative BTA effect top-up timing in cases at high recurrence remains uncertain. This study was designed assess value electromyography (EMG) determining appropriate time for top-up. Methods: 56 patients underwent with pre-operative infiltration obliques. Eleven...
Pharyngeal and respiratory sensation is impaired in obstructive sleep apnea (OSA). Opioids may further diminish sensation. Thus protective pharyngeal neuromuscular arousal responses to airway occlusion that rely on could be with opioids worsen OSA severity. However, little known about the effects of upper people OSA. This study was designed determine 40 mg MS-Contin tactile sensation, load detection, magnitude perception during wakefulness. A double-blind, randomized, crossover design (1 wk...
Background Endovenous radio frequency ablation for small saphenous vein incompetence by and large appears to be superior safer than conventional open surgery. Small from approximately mid-calf the point proximally where dives into popliteal fossa is considered safe, as sural nerve in most cases separated this segment of deep fascia. The outcome distal incompetent remains unclear. Efficacy endovenous can enhanced increasing length ablatable segment. Methodology To optimise outcome, may made...
The Brazilian Lyme-disease-like illness (BLDLI) or Baggio-Yoshinari syndrome is a unique zoonosis found in Brazil. It reproduces all the clinical symptoms of Lyme disease except for high frequencies relapse and presence autoimmune manifestations. Two cases borreliosis manifesting with unremitting headache, which symptom associated late-stage BLDLI, were presented. Clinical, therapeutic, prognostic aspects BLDLI its headaches showed discussed this article. diagnosis requires additional...
Abstract Background: Post-dural puncture headache (PDPH) is an iatrogenic condition following lumbar (LP). Incidence variable and often associated with young females. Technical features of the procedure (i.e. needle gauge) have been investigated; however there no investigation on method cerebrospinal fluid (CSF) collection. Objective: To investigate whether mild CSF aspiration increased PDPH in selected patients. Methods: 336 subjects were eligible to study. Data 237 patients from a tertiary...
Both awake ventilatory control measures and OSA endotypes measured during sleep have reported potentials in endotyping/phenotyping OSA, although no randomized, controlled trial has compared/linked between the two techniques. From a double-blind, randomized placebo-controlled crossover trial, we found that of respiratory are related to physiological such as airway collapsibility arousal threshold severity. Awake chemosensitivity best potential predict changes severity with morphine.
Mucosal vaccination appears to be suitable protect against SARS-CoV-2 infection. In this study, we tested an intranasal mucosal vaccine candidate COVID-19 constituted of a cationic liposome containing trimeric spike protein and CpG-ODNs, Toll-like receptor 9 agonist, as adjuvant. vitro in vivo experiments indicated the absence toxicity following administration formulation. First, found that subcutaneous or protected hACE-2 transgenic mice from infection with wild-type (Wuhan) strain, shown...
Background Recurrence rates and patterns after endovenous radiofrequency ablation (ERFA) are poorly documented. Objective To assess the incidence anatomical recurrence of saphenous vein reflux ERFA. Method Two hundred patients previously treated with ERFA were recalled for clinical assessment venous-duplex ultrasound at three years post-treatment. Results A total 106 (68F, 38M) a mean age 49.4 (SD +11.5y) assessed. Mean follow-up was 42.1 months + 20.1m). Further varicose veins identified in...
Charles Bonnet syndrome (CBS) is a neuro-ophthalmic condition that affects elderly people with visual impairment related to ophthalmological pathologies. It characterized by complex hallucinations with insight into the unreality of perceptions and preserved cognitive status. Its mechanism involves spontaneous neuronal discharges cortex secondary deafferentation input. Treatment should address its ophthalmologic etiology but pharmacological management may be done as well. We report case...