A5085392142- Migraine and Headache Studies
- Trigeminal Neuralgia and Treatments
- Neuropeptides and Animal Physiology
- Neuroendocrine regulation and behavior
- Pain Mechanisms and Treatments
- Sympathectomy and Hyperhidrosis Treatments
- Nitric Oxide and Endothelin Effects
- Ophthalmology and Visual Health Research
- Neurological Complications and Syndromes
- Hormonal Regulation and Hypertension
- Blood Pressure and Hypertension Studies
- Neuroscience of respiration and sleep
- Ophthalmology and Eye Disorders
- Sexual function and dysfunction studies
- Adenosine and Purinergic Signaling
- Maternal Mental Health During Pregnancy and Postpartum
- Telomeres, Telomerase, and Senescence
- Sodium Intake and Health
- Medical and Biological Sciences
- Transcranial Magnetic Stimulation Studies
- Moyamoya disease diagnosis and treatment
- Renin-Angiotensin System Studies
- Circadian rhythm and melatonin
- Heart rate and cardiovascular health
- Cerebral Venous Sinus Thrombosis
King's College London
2022-2025
Erasmus MC
2017-2024
Intra Cellular Therapies (United States)
2021
Erasmus University Rotterdam
2017-2019
Center for Research and Advanced Studies of the National Polytechnic Institute
2017
Universidad Nacional Autónoma de México
2015
Abstract Migraine headache pathophysiology involves trigeminovascular system activation, calcitonin gene-related peptide (CGRP) release, and dysfunctional nociceptive transmission. Triptans are 5-HT 1B/1D/(1F) receptor agonists that prejunctionally inhibit trigeminal CGRP but their vasoconstrictor properties limit use in migraine patients with cardiovascular disease. By contrast, lasmiditan is a novel antimigraine selective 1F agonist devoid of properties. On this basis, study has...
Background Migraine has been associated with a dysfunctional activation of the trigeminovascular system. Calcitonin gene-related peptide, neuropeptide released from trigeminal nerve fibres, an important role in pathophysiology migraine and is current therapeutic target for treatment. Methods We examined effects two novel calcitonin peptide receptor antagonists, ubrogepant atogepant, on relaxations induced by α human isolated middle meningeal, cerebral coronary arteries. Furthermore,...
Background and Purpose Triptans are 5‐HT 1B/1D receptor agonists (that also display 1F affinity) with antimigraine action, contraindicated in patients coronary artery disease due to their vasoconstrictor properties. Conversely, lasmiditan was developed as an agonist. To assess the selectivity cardiovascular effects of lasmiditan, we investigated binding, functional activity, vitro/in vivo vascular compared it sumatriptan. Experimental Approach Binding second messenger activity assays other...
Multiple drugs targeting the calcitonin gene-related peptide (CGRP) receptor have been developed for migraine treatment. Here, effect of monoclonal antibody erenumab on CGRP-induced vasorelaxation was investigated in human isolated blood vessels, as well combining with small molecule drugs, namely rimegepant, olcegepant, or sumatriptan.
Background Migraine prevalence and levels of calcitonin gene-related peptide (CGRP), a involved in migraine pathophysiology, differ between men women, appear to be affected by changes sex hormones. The present study investigated the sex-specific responses CGRP human isolated arteries. Methods CGRP-induced relaxation 62 (28 34 women) middle meningeal arteries (HMMA) 139 (69 70 coronary (HCA) was compared women groups <50 years ≥50 age as proxy for pre- postmenopausal status well...
Migraine is associated with activation of the trigeminovascular system, release calcitonin gene-related peptide (CGRP) and dilation dural arteries. Novel treatments target or its receptor, which are present in all vascular beds, raising cardiovascular concerns. Erenumab a human CGRP-receptor antibody approved for prophylactic treatment migraine.We characterised relaxant responses to CGRP absence presence erenumab (1 μM) isolated middle meningeal, internal mammary (proximal distal) coronary...
Abstract Raised intracranial pressure (ICP) is associated with altered cerebral hemodynamics and cephalic pain. The relationship between the algetic response cortical neurovascular changes in raised ICP unclear. This study aimed to evaluate this determine if lowering (using a glucagon like peptide-1 receptor agonist) could ameliorate response. We also sought explore role of calcitonin gene-related peptide pain driven by inhibiting signalling quantifying In rat model ICP, created...
Background The current understanding of mechanisms behind migraine pain has been greatly enhanced with the recent therapies targeting calcitonin gene-related peptide and its receptor. clinical efficacy peptide-blocking drugs indicates that, at least in a considerable proportion patients, is key molecule pain. There are several receptors molecular pathways that can affect release response to peptide. One these could be purinergic involved nociception, but understudied respect migraine....
Abstract We previously identified genomic instability as a causative factor for vascular aging. In the present study, we determined which aging outcomes are due to local endothelial DNA damage, was accomplished by genetic removal of ERCC1 (excision repair cross-complementation group 1) in mice (EC-knockout (EC-KO) mice). EC-KO showed progressive decrease microvascular dilation skin, increased leakage kidney, decreased lung perfusion, and aortic stiffness compared with wild-type (WT)....
Background: Migraine is more prevalent in women, and although the mechanisms involved this disparity remain poorly understood, an interaction between trigeminovascular system cycling estrogen levels biologically-predisposed women has been suggested. We investigated role of amylin 1 (AMY1) receptor activation modulation trigeminal nociceptive female rats across estrous cycle stages with falling rising compared these to responses males. Methods: recorded neuronal activity vivo within...