A5084413123- Neuropeptides and Animal Physiology
- Migraine and Headache Studies
- Nitric Oxide and Endothelin Effects
- Receptor Mechanisms and Signaling
- Trigeminal Neuralgia and Treatments
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Neuroscience of respiration and sleep
- Renin-Angiotensin System Studies
- Neurological Disorders and Treatments
- Pain Mechanisms and Treatments
- Sympathectomy and Hyperhidrosis Treatments
- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Cerebrovascular and Carotid Artery Diseases
- Heart Rate Variability and Autonomic Control
- Hormonal Regulation and Hypertension
- Neuroendocrine regulation and behavior
- Biochemical effects in animals
- Adenosine and Purinergic Signaling
- Neurological Disease Mechanisms and Treatments
- S100 Proteins and Annexins
- Neurological Complications and Syndromes
- Olfactory and Sensory Function Studies
Lund University
2016-2025
Rigshospitalet
2015-2024
Glostrup Hospital
2015-2024
Copenhagen University Hospital
2015-2024
Getinge (Sweden)
2015-2024
Umeå University
1972-2022
Skåne University Hospital
2010-2021
New York Proton Center
2020
American Headache Society
2020
Rotterdam University of Applied Sciences
2019
Abstract The innervation of the cranial vessels by trigeminal nerve, trigeminovascular system, has recently been subject study in view its possible role mediation some aspects migraine. Since stimulation ganglion humans leads to facial pain and flushing associated release powerful neuropeptide vasodilator substances, their local into extracerebral circulation was determined patients who had either common or classic Venous blood sampled from both external jugular cubital fossa ipsilateral...
Abstract Both clinical and physiological consideration of migraine suggests that the pathophysiology syndrome is intimately linked to trigeminal innervation cranial vessels, trigeminovascular system. Studies were conducted on cats humans examine interaction these systems with effective acute antimigraine drugs dihydroergotamine sumatriptan. In animal studies anesthetized prepared for routine monitoring as well blood sampling from external jugular veins. Cerebral flow was monitored...
Abstract The trigeminal ganglion was activated, in humans by thermocoagulation as part of the treatment neuralgia and cats electrical stimulation, blood samples were taken from external jugular vein for estimates plasma levels substance P calcitonin gene‐related peptide (CGRP). In those patients who noted at time coagulation to have flushed there marked elevations local (cranial) both peptides. However, nonflushing no changes observed. Parallel experiments cat revealed that P—like CGRP‐like...
Cluster headache is a rare very severe disorder that clinically well characterized with relatively poorly understood pathophysiology. In this study patients episodic cluster fulfilling the criteria of International Headache Society were examined during an acute spontaneous attack to determine local cranial release neuropeptides. Blood was sampled from external jugular vein ipsilateral pain before and after treatment attack. Samples assayed for calcitonin gene-related peptide (CGRP),...
Distribution studies disclosed that all major cerebral arteries and cortical arterioles of the cat were invested with fine varicose nerve fibers contained calcitonin gene-related peptide (CGRP)-like immunoreactivity; trigeminal ganglia likewise CGRP immunoreactivity. Sequential immunostaining antibodies to substance P (SP) revealed identical distributions these two peptides in cerebrovascular fibers, suggesting SP are colocalized nerves. completely disappeared from ipsilateral blood vessels...
A sensitive device for recording of mechanical activity in isolated small blood vessels with calibres down to 100 μm is described. This equipment was used examine the properties rat cerebral arteries. The ultrastructure preparations investigated by light‐, transmission, and scanning electron‐microscopy. In general walls middle basilar arteries consisted 3 layers smooth muscle cells, which occupied approximately 80% total wall thickness. present technique preserved integrity vessel caused no...
The contractile effect of neuropeptide Y (NPY) was tested on isolated segments basilar artery, central ear gastro-epiploic artery and vein, femoral vein from the rabbit. At 30 nM NPY did not evoke vasoconstriction; at 300 evoked a weak variable response. greatly potentiated response arteries to noradrenaline without affecting maximum As effective concentrations 1 higher. potentiating noradrenaline-evoked contractions apparent immediately min after application NPY, but one hour. (30 nM)...
<h3>Objective:</h3> To evaluate whether the calcitonin gene-related peptide (CGRP) receptor antagonist telcagepant might be effective for migraine prevention. <h3>Methods:</h3> In this randomized, double-blind, placebo-controlled, multicenter trial (ClinicalTrials.govNCT00797667), patients experiencing 3–14 days during a 4-week baseline were randomized to 140 mg, 280 or placebo twice daily 12 weeks. Efficacy was assessed by mean monthly headache and migraine/probable (headache plus ≥1...