A5074754860- Birth, Development, and Health
- Pregnancy and preeclampsia studies
- Trypanosoma species research and implications
- Calcium signaling and nucleotide metabolism
- Health and Lifestyle Studies
- Viral-associated cancers and disorders
- Rheumatoid Arthritis Research and Therapies
- Nitric Oxide and Endothelin Effects
- Lysosomal Storage Disorders Research
- Telomeres, Telomerase, and Senescence
- Folate and B Vitamins Research
- Biomarkers in Disease Mechanisms
- Systemic Lupus Erythematosus Research
- DNA Repair Mechanisms
- SARS-CoV-2 and COVID-19 Research
- Genetics, Aging, and Longevity in Model Organisms
- Gestational Diabetes Research and Management
- Virus-based gene therapy research
- Parvovirus B19 Infection Studies
- Lymphoma Diagnosis and Treatment
- Mitochondrial Function and Pathology
- COVID-19 Clinical Research Studies
- Coenzyme Q10 studies and effects
- Histiocytic Disorders and Treatments
- Autophagy in Disease and Therapy
Fundación Cardiovascular de Colombia
2019-2024
Erasmus MC
2015-2023
Erasmus University Rotterdam
2015-2023
Weatherford College
2021
Universidad de Santander
2021
Universidad del Valle
2021
Czech Academy of Sciences, Biology Centre
2019
Universidad Autónoma de Bucaramanga
2011-2012
Colciencias
2011
Hospital Universitario de Guadalajara
2009
Abstract Heart failure has reached epidemic proportions in a progressively ageing population. The molecular mechanisms underlying heart remain elusive, but evidence indicates that DNA damage is enhanced failing hearts. Here, we tested the hypothesis endogenous repair cardiomyocytes critical for maintaining normal cardiac function, so perturbed of spontaneous drives early onset failure. To increase burden damage, knocked out endonucleases xeroderma pigmentosum complementation group G (XPG)...
Reduced nitric oxide (NO)/cGMP signalling is observed in age-related vascular disease. We hypothesize that this disturbed involves effects of genomic instability, a primary causal factor aging, on smooth muscle cells (VSMCs) and the underlying mechanism plays role human To test our hypothesis, we combined experiments mice with instability resulting from defective nucleotide excision repair gene ERCC1 (Ercc1d/− mice), VSMC cultures population genome-wide association studies (GWAS). Aortic...
Abstract We previously identified genomic instability as a causative factor for vascular aging. In the present study, we determined which aging outcomes are due to local endothelial DNA damage, was accomplished by genetic removal of ERCC1 (excision repair cross-complementation group 1) in mice (EC-knockout (EC-KO) mice). EC-KO showed progressive decrease microvascular dilation skin, increased leakage kidney, decreased lung perfusion, and aortic stiffness compared with wild-type (WT)....
Neutralizing antibody (NAb) activity against the viral capsid of adeno-associated (AAV) vectors decreases transduction efficiency, thus limiting transgene expression. Several reports have mentioned a variation in NAb prevalence according to age, AAV serotype, and, most importantly, geographic location. There are currently no specifically describing anti-AAV Latin America. Here, we describe different serotypes (AAV1, AAV2, and AAV9) Colombian patients with heart failure (HF) (referred as...
Methotrexate-associated lymphoproliferative disorders are a heterogeneous group of lymphoid proliferations or lymphomas that develop in patients with autoimmune diseases treated using methotrexate. These often associated Epstein-Barr virus infection and occasionally regress after the withdrawal methotrexate therapy. The disorder this case was diffuse large B-cell lymphoma, unusually presenting as oral ulcers 79-year-old woman on treatment for longstanding rheumatoid arthritis. Latent...
DNA damage is an important contributor to endothelial dysfunction and age-related vascular disease. Recently, we demonstrated in a repair-deficient, prematurely aging mouse model (Ercc1Δ/- mice) that dietary restriction (DR) strongly increases life- health span, including ameliorating dysfunction, by preserving genomic integrity. In this mutant displaying prominent accelerated, age-dependent investigated the signaling pathways involved improved endothelium-mediated vasodilation DR, explore...
Chronic Chagas Cardiomyopathy (CCM) is characterized by a unique pathophysiology in which inflammatory, microvascular and neuroendocrine processes coalesce the development of one most severe cardiomyopathies affecting humans. Despite significant advances understanding molecular mechanisms involved this disease, scarce information available regarding microRNAs clinical parameters disease severity. We aimed to evaluate association between circulating levels six with markers myocardial injury...
Multiple small studies have suggested that women with pre-eclampsia present elevated levels of C-reactive protein (CRP) and interleukin-6 (IL-6). However, little is known regarding the source this CRP IL-6 increase. Therefore, aim study was to evaluate relationship between considering different confounding factors. Using data from a large Colombian case-control (3,590 cases 4,564 normotensive controls), were measured in 914 1297 controls. The association maternal serum risk evaluated using...
Angiogenic factors, such as placental growth factor (PlGF) and soluble Flt-1 (sFlt-1), are key regulators of vascular development. Evidence from in vitro studies indicates that fatty acids can affect angiogenesis. We investigated the associations maternal fish consumption levels with angiogenic factors during pregnancy, cord blood a large population-based prospective cohort. First trimester was assessed among 3134 pregnant women using food-frequency questionnaire. Plasma acid were measured...
Infection with Trypanosoma cruzi Chagas, 1909 is reported to increase the production of reactive oxygen species in patients Chagas disease.Mitochondria dysfunction, host inflammatory response and inadequate antioxidant are described as main factors leading oxidative stress during acute chronic stages disease.The Seahorse XFe24 extracellular flux platform allows energy metabolism determination through mitochondrial respiration glycolysis measurements.XFe24 can be used vitro models T....
The emergence of SARS-CoV-2, the virus causing COVID-19, has resulted in a pandemic that disrupted all sectors society. Less than year after sequencing virus’s genome, emergency use authorization for BNT162b2 vaccine was requested. aim this study to evaluate response BNT162b2-mRNA COVID-19 frontline workers from two hospitals Colombia. Nasopharyngeal swabs were collected molecular detection SARS-CoV-2 using real-time PCR, and blood samples taken assess seroconversion qualitative quantitative...