A5055693428- Pharmaceutical studies and practices
- Pharmaceutical Practices and Patient Outcomes
- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Patient Safety and Medication Errors
- Medication Adherence and Compliance
- Pharmacovigilance and Adverse Drug Reactions
- Antibiotic Use and Resistance
- Pharmacy and Medical Practices
- Asthma and respiratory diseases
- Health Sciences Research and Education
- Child and Adolescent Health
- Pain Management and Opioid Use
- Healthcare Decision-Making and Restraints
- Respiratory and Cough-Related Research
- Metabolism and Genetic Disorders
- Neonatal and fetal brain pathology
- Healthcare Technology and Patient Monitoring
- Musculoskeletal pain and rehabilitation
- Pregnancy and Medication Impact
- Health Systems, Economic Evaluations, Quality of Life
- Antibiotics Pharmacokinetics and Efficacy
- Infant Development and Preterm Care
- Electronic Health Records Systems
- Pediatric Pain Management Techniques
Leipzig University
2016-2025
University Hospital Leipzig
2016-2025
University of Freiburg
2024
Bundeswehrkrankenhaus
2024
GTx (United States)
2023
Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie
2021
Heidelberg University
2005-2016
University Hospital Heidelberg
2005-2016
Klinikum Konstanz
2016
Heidelberg University
2007-2010
The frequency of drug administration errors and incompatibilities between intravenous drugs before after an intervention in intensive care unit (ICU) is discussed.Critically ill adult patients with intoxications, multiorgan failure, serious infections were included a retrospective analysis prospective two-period, one-sequence study. In the analysis, most frequent brands i.v. medications used ICU gastroenterologic department teaching hospital identified. All possible combinations resulting...
<h3>Objectives</h3> Prescription of excessive doses is the most common prescription error, provoking dose-dependent adverse drug reactions. Clinical decision support systems (CDSS) can prevent errors especially when mainly clinically relevant warnings are issued. We have built and evaluated a CDSS providing upper dose limits personalised to individual patient characteristics thus guaranteeing for specific warnings. <h3>Methods</h3> For 170 compounds, detailed information on (according label)...
Children treated in a pediatric intensive care unit (PICU) often receive several drugs together, among them defined as high-alert medications (HAMs). Those carry high risk of causing patient harm, for example, due to higher potential interactions. HAMs should therefore be administered with caution, especially PICU.
Background/Objectives: In older patients, falls constitute a significant public health concern and major cause of hospital admission. Fall-risk-increasing drugs (FRIDs) represent key risk factor for falls. Therefore, modifying these represents an important strategy preventing recurrent further patient harm. The objective this study was to evaluate structured interprofessional collaboration between physicians pharmacists on managing FRIDs in patients who present the emergency department (ED)...
Purpose We aimed to explore the perspectives of parents children with epilepsy regarding extent adverse drug reactions (ADRs) antiseizure medications (ASMs) they are willing accept for a certain degree seizure reduction. Methods presented table showing two levels likelihood occurrence (low/high) and severity (mild/severe) number ADRs including irritability, impairment attention, fatigue. For each combination severity, 98 were asked indicate reduction which given ADR. Results Even in exchange...
Adverse drug reactions (ADRs) occur frequently in the treatment with antiseizure medication (ASM). We investigated influence of experienced ADRs on desired or actual modifications paediatric patients from parents' perspective. interviewed 104 parents children an epilepsy diagnosis routine care at a German university hospital. The questionnaire comprised questions about current and previous experiences ASM regarding leading to modifications. Of 94 ASM, 11/94 (12 %) because ADRs. 66 treatment,...
Abstract Background Severe asthma and moderate-to-severe atopic dermatitis can significantly impact the lives of children adolescents. However, real-world data on pediatric patients’ perceptions their medication are limited. Methods This non-interventional cross-sectional study at a university hospital explored perceptions. We included patients aged between 6 17 with severe and/or dermatitis. For treated dupilumab, minimum dupilumab treatment duration 16 weeks was required. conducted one...
<h3>Background</h3> Drug administration in children is an error-prone task for nurses and parents because individual dose adjustment often necessary, suitable formulations are frequently lacking. Hence, the absence of measures their prevention, medication errors likely to occur. <h3>Objective</h3> To assess error prevalence drug by mouth or gastric tube before after implementing a programme quality improvement parents. <h3>Design, setting participants</h3> Prospective, two-period cohort...
Aims and objectives To prevent medication errors in drug handling a paediatric ward. Background One five preventable adverse events hospitalised children is caused by errors. Errors prescription have been studied frequently, but data regarding handling, including preparation administration, are scarce. Design A three‐step intervention study monitoring procedure was used to detect handling. Methods After approval the ethics committee, pharmacists monitored nurses on an 18‐bed ward university...
Problem School and preschool teachers play a key role in the care of children with epilepsy. Yet, data about their knowledge on epilepsy are scarce. Methods Assessment attitudes towards by conducting questionnaire survey Leipzig Blankenburg, Germany, from August 2013 to January 2014. Results 1243 questionnaires were completed 302 school teachers, 883 56 students two unclassified participants. Of respondents, 140 (11%) stated have already been actively involved an emergency situation, another...
A prospective controlled intervention cohort study in cancer pain patients (n=50 per group) admitted to radiation oncology wards (62 beds, 3 wards) was conducted a 1621-bed university hospital. We investigated the effect of an consisting daily assessment using numeric visual analog scale (NVAS) and therapy counseling clinicians based on computerized clinical decision support system (CDSS) correct deviations from guidelines. Effects guideline adherence (primary outcome), relief at rest during...
In Germany, preschool teachers supervise children up to six years of age and are also responsible for supervising older pupils after school. This study explored the impact a teaching session on epilepsy in charge from 1 10 age.We evaluated benefit offered all Leipzig, 2014-2015, by asking them complete same questionnaire 12-24 months pre-intervention, 12 postintervention.Both questionnaires were completed 123 teachers. The number who felt they prepared handle an acute seizure rose 36 (29%)...
Background: to assess the intuitiveness of parents’ administration pediatric emergency devices (inhalation, rectal, buccal, nasal, and auto-injector). Methods: We invited parents without prior experience administer five dummy dolls. observed whether chose correct route subsequently performed procedures clinically relevant errors. interviewed for their self-assessment own performance willingness in actual emergencies. Results: The was best inhalation device (81/84, 96% parents) worst...
Commercially available extracts from <i>Boswellia serrata</i> resin used as anti-inflammatory drugs or phytonutrients show paradoxical concentration-dependent potentiating and inhibitory actions on 5-lipoxygenase (5-LO) product synthesis in stimulated PMNs. In our attempt to characterize the stimulating constituents, we identified tetracyclic triterpene 3-oxo-tirucallic acid (3-oxo-TA), which, range 2.5 15 μM, enhanced 5-LO formation ionophore-challenged polymorphonuclear cells (PMNs) (e.g.,...