A5088929193- Dialysis and Renal Disease Management
- Erythropoietin and Anemia Treatment
- Central Venous Catheters and Hemodialysis
- Health Systems, Economic Evaluations, Quality of Life
- Blood Pressure and Hypertension Studies
- Chronic Kidney Disease and Diabetes
- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Renal and Vascular Pathologies
- Electrolyte and hormonal disorders
- Pharmacological Effects and Toxicity Studies
- Muscle and Compartmental Disorders
- Geriatric Care and Nursing Homes
- Restless Legs Syndrome Research
- Acute Kidney Injury Research
- Potassium and Related Disorders
- Hemodynamic Monitoring and Therapy
- Platelet Disorders and Treatments
- Renal Transplantation Outcomes and Treatments
- Renal function and acid-base balance
- Healthcare Policy and Management
- Palliative Care and End-of-Life Issues
- Parkinson's Disease Mechanisms and Treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Parathyroid Disorders and Treatments
George Washington University
2021-2024
Milken Institute
2023
Renaissance Services (United States)
2019-2022
Colorado Kidney Care
2022
AstraZeneca (United Kingdom)
2021
AstraZeneca (United States)
2020-2021
Arbor Research Collaborative for Health
2021
Baxter (United States)
2011-2020
Wilmington University
2020
Deerfield (United States)
2013-2019
Abstract Objective Safer and more effective therapies are needed for the treatment of systemic lupus erythematosus (SLE). B lymphocytes have been shown to play fundamental pathogenic roles in SLE, therefore, elimination cells with use rituximab may represent a new therapy SLE. Methods A phase I/II dose‐escalation trial added ongoing SLE was conducted. Rituximab administered as single infusion 100 mg/m 2 (low dose), 375 (intermediate or 4 infusions (1 week apart) (high dose). CD19+ were...
Infection is the Achilles heel of peritoneal dialysis. Exit site mupirocin prevents Staphylococcus aureus dialysis (PD) infections but does not reduce Pseudomonas aeruginosa or other Gram-negative infections, which are associated with considerable morbidity and sometimes death. Patients from three centers (53% incident to PD 47% prevalent) were randomized in a double-blinded manner daily gentamicin cream catheter exit site. Infections tracked prospectively by organism expressed as episodes...
PURPOSE: To determine if the natural anticoagulant protein C plays a role in pathogenesis of systemic calciphylaxis, syndrome characterized by extensive vascular and soft tissue calcification skin necrosis, which is similar to that seen warfarin-induced necrosis.PATIENTS AND METHODS: The study population included five patients with end-stage renal disease calciphylaxis undergoing hemodialysis, 12 without evidence dialysis, eight nephrotic syndrome, normal healthy volunteers.Protein antigen...
♦Extending technique survival on peritoneal dialysis (PD) remains a major challenge in optimizing outcomes for PD patients while increasing utilization. The primary objective of the Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS) is to identify modifiable practices associated with improvements patient survival. In collaboration International Society (ISPD), PDOPPS seeks standardize PD-related data definitions provide forum effective international collaborative clinical...
A study was undertaken to ascertain the effects of recombinant human erythropoietin (r-HuEPO) on renal function in chronic failure predialysis patients. The effect improvement anemia by r-HuEPO rate decline patients has not been previously studied prospectively a large number using reliable measures glomerular filtration (GFR). To investigate efficacy, safety, and impact therapy insufficiency patients, 48-week, randomized, open-label, multicenter initiated 83 anemic, (serum creatinine 3 8...
Remote patient management (RPM) offers renal health care providers and patients with end-stage kidney disease opportunities to embrace home dialysis therapies greater confidence the potential obtain better clinical outcomes. Barriers evidence required increase adoption of RPM by nephrology community need be clearly defined. Ten from specialties including nephrology, cardiology, pediatrics, epidemiology, nursing, informatics experience in use systems gathered Vienna, Austria discuss for,...
Quantifying contemporary peritoneal dialysis time on therapy is important for patients and providers. We describe in the context of outcomes hemodialysis transfer, death, kidney transplantation basis multinational, observational Peritoneal Dialysis Outcomes Practice Patterns Study (PDOPPS) from 2014 to 2017.Among 218 randomly selected facilities (7121 patients) PDOPPS Australia/New Zealand, Canada, Japan, Thailand, United Kingdom, States, we calculated cumulative incidence start or over 5...
Remote monitoring (RM) is defined as the surveillance of device-transmitted outpatient data. RM expected to enable better management chronic diseases. The objective this research was identify public policies concerning in four European countries. Searches medical literature, Internet, and Ministry Health websites for United Kingdom (UK), Germany, Italy, Spain were performed order diseases, including end stage renal disease (ESRD), pulmonary obstructive (COPD), diabetes, heart failure,...
Hypokalemia, including normal range values <4 mEq/l, has been associated with increased peritonitis and mortality in patients peritoneal dialysis. This study sought to describe international variation hypokalemia, potential modifiable hypokalemia risk factors, the covariate-adjusted relationship of mortality.Baseline serum potassium was determined 7421 from 7 countries Peritoneal Dialysis Outcomes Practice Patterns Study (2014-2017). Association baseline patient treatment factors subsequent...
Transition to hemodialysis (HD) is a common outcome in peritoneal dialysis (PD), but the associated mortality risk poorly understood. This study sought identify rates of and factors for after transitioning from PD HD.Patients with incident (between 2000 2014) who transferred HD ≥1 day were identified, using data Australia New Zealand Dialysis Transplantation registry (ANZDATA), Canadian Organ Replacement Register (CORR), Europe Renal Association (ERA) Registry, United States System (USRDS)....
Cystinuria is characterized by cystine stone formation and loss of renal function. Conservative therapy generally ineffective penicillamine can be complicated serious side effects. To our knowledge, we report the first clinical use captopril in treatment homozygous cystinuria two siblings. In patient, a 70% reduction excretion was observed after 26 weeks with 150 mg/d captopril. Discontinuation drug resulted return to baseline excretion, further function, nephrotic range proteinuria....
For chronic kidney disease patients who progress to end-stage renal disease, survival is dependent on replacement therapy in the form of transplantation or dialysis. Peritoneal dialysis (PD), which can be performed at home, both more convenient and less costly than hemodialysis that requires three 4-h visits per week facility complicated equipment. Remote management (RTM), technologies collect medical information transmit it healthcare providers for patient management, has potential improve...
Abstract Previously lacking in the literature, we describe longitudinal patterns of anemia prescriptions for non-dialysis-dependent chronic kidney disease (NDD-CKD) patients under nephrologist care. We analyzed data from 2818 Stage 3-5 NDD-CKD Brazil, Germany, and US, naïve to medications (oral iron, intravenous [IV] or erythropoiesis stimulating agent [ESA]) at enrollment CKDopps. report cumulative incidence function (CIF) medication initiation stratified by baseline characteristics. Even...
Cardiovascular events are the dominant cause of death in patients with ESRD. Until recently, plaque rupture due to atherogenic dyslipoproteinemias was presumed be a major mechanism cardiovascular dialysis patients. But how reasonable that hypothesis and it entirely discredited by results 4D AURORA? This article places conventional lipids—cholesterol triglyceride—within more physiologic framework apoB lipoproteins. Viewed from perspective particle number, failure statins lower mortality...
Nonmedical factors influencing utilization of home dialysis at the facility level are poorly quantified. Home is comparably effective and safe but less expensive to society Medicare than in-center hemodialysis. Elimination modifiable practice variation unrelated medical could contribute improvements in patient outcomes use scarce resources.Prevalent data by were collected from 2007 ESRD Network's annual reports. Facility characteristic Medicare's Dialysis Compare file. A multivariate...
Background United States Renal Data System (USRDS) data from 2014 show that African Americans (AA) are underrepresented in the home dialysis population, with 6.4% versus 9.2% utilization general populace. This racial disparity may be inaccurately ascribed to nation as a whole if regional and inter-state variability exists. investigation sought examine by minority Medicare beneficiary populations across US nationally, regionally, individual state. Methods The 2012 100% Outpatient Standard...
Patient-reported measures are increasingly recognized as important predictors of clinical outcomes in peritoneal dialysis (PD). We sought to understand associations between patient-reported perceptions the advantages and disadvantages PD outcomes.In this cohort study, 2760 patients Peritoneal Dialysis Outcomes Practice Patterns Study (PDOPPS) completed a questionnaire on their experience, 2014 2017. In questionnaire, PDOPPS rated 17 aspects experience 5-category ordinal scale, with responses...
Optimal management of anemia chronic kidney disease (CKD) remains controversial. This retrospective study aimed to describe the epidemiology and selected clinical outcomes in patients with CKD US.Data were extracted from Henry Ford Health System databases. Adults stages 3a-5 not on dialysis (estimated glomerular filtration rate < 60 mL/min/1.73m2) between January 1, 2013 December 31, 2017 identified. Patients renal replacement therapy or active cancer bleeding excluded. followed for ≥12...
Hemodialysis only partially corrects the defects in platelet function associated with uremia. Platelet contact artificial surfaces of dialysis filter during hemodialysis can itself cause activation, degranulation, and loss membrane glycoproteins. Although transient dysfunction that occurs after foreign cardiopulmonary bypass has been well characterized, there no such investigation hemodialysis. In this study patients, bleeding times (BT) response their platelets to thrombin, ristocetin,...