A5045832305- Dialysis and Renal Disease Management
- Iron Metabolism and Disorders
- Blood Pressure and Hypertension Studies
- Nutritional Studies and Diet
- Chronic Kidney Disease and Diabetes
- Sodium Intake and Health
- Erythropoietin and Anemia Treatment
- Nutrition and Health in Aging
- Hemoglobinopathies and Related Disorders
- Central Venous Catheters and Hemodialysis
- Bipolar Disorder and Treatment
- Potassium and Related Disorders
- Healthcare cost, quality, practices
- Health Systems, Economic Evaluations, Quality of Life
- Electrolyte and hormonal disorders
- COVID-19 Clinical Research Studies
- Healthcare Systems and Reforms
- Analytical Chemistry and Chromatography
- Chronic Lymphocytic Leukemia Research
- Pharmaceutical Economics and Policy
- Lipoproteins and Cardiovascular Health
- Aortic Thrombus and Embolism
- SARS-CoV-2 and COVID-19 Research
- Renal and Vascular Pathologies
- Therapeutic Uses of Natural Elements
University of British Columbia
2002-2025
Scripps Health
2024
Merck & Co., Inc., Rahway, NJ, USA (United States)
2024
Imperial College London
2023
National University Health System
2023
National University of Singapore
2023
George Institute for Global Health
2023
Creative Commons
2023
Manipal Academy of Higher Education
2023
University of Minnesota
2023
Chronic kidney disease (CKD) affects over 850 million people globally, and the need to prevent its development progression is urgent. During past decade, new perspectives have arisen related quality precision of care for CKD, owing tools interventions CKD diagnosis management. New biomarkers, imaging methods, artificial intelligence techniques, approaches organizing delivering healthcare may help clinicians recognize determine etiology, assess dominant mechanisms at given time points,...
High interdialytic weight gain (IDWG) is associated with adverse outcomes in hemodialysis (HD) patients. We identified temporal and regional trends IDWG, predictors of associations IDWG clinical outcomes.Analysis 1: sequential cross-sections to identify facility- patient-level their trends. Analysis 2: prospective cohort study assess between mortality hospitalization risk.21,919 participants on HD therapy for 1 year or longer the Dialysis Outcomes Practice Patterns Study (DOPPS) phases 2 5...
International variation in anemia assessment and management practices chronic kidney disease (CKD) is poorly understood.We performed a cross-sectional analysis of laboratory monitoring, prevalence the prospective Chronic Kidney Disease Outcomes Practice Patterns Study (CKDopps). A total 6766 participants with CKD Stages 3a-5ND from nephrology clinics Brazil, France, Germany USA were included.Among patients (hemoglobin <12 g/dL), 36-58% had repeat hemoglobin measured 40-61% iron indices...
Significance Statement Management of iron deficiency in patients with nondialysis CKD focuses on improving erythropoiesis. Studies heart failure similar pathogenesis found that treating improves cardiovascular outcomes, regardless anemia. To evaluate a possible anemia-independent association stores outcomes individuals CKD, the authors studied nephrology-based clinics from multinational cohort. They show deficiency, as reflected by transferrin saturation index, is associated higher risk...
The uptake of the Kidney Disease: Improving Global Outcomes (KDIGO) 2012 chronic kidney disease (CKD) Guideline is not fully described in real-world nephrology practice across world.We used baseline data from CKD and Practice Patterns Study (2013-2017), a 4-country cohort patients with estimated glomerular filtration rate <60 ml/min per 1.73 m2 recruited national samples clinics, to describe adherence measures for monitoring delaying progression. Data were collected as clinical practice,...
Essential medicines are defined as those that "satisfy the priority health care needs of population" and selected with due regard to public relevance based on their efficacy, safety, comparative cost-effectiveness.1World Health Organization The Selection Use Medicines. Report WHO Expert Committee (Including 12th Model List Medicines). WHO, 2003Google Scholar They intended be accessible within context functioning systems in adequate quantities, appropriate dosage forms, ensured quality...
Conflicting findings and knowledge gaps exist regarding links between anemia, physical activity, health-related quality of life (HRQOL), chronic kidney disease (CKD) progression, mortality in moderate-to-advanced CKD. Using the CKD Outcomes Practice Patterns Study, we report associations hemoglobin (Hgb) with HRQOL Hgb activity progression stage 3-5 nondialysis (ND)-CKD patients.Prospectively collected data were analyzed from 2,121 ND-CKD patients, aged ≥18 years, at 43 nephrologist-run US...
Abstract Renin‐angiotensin‐aldosterone system inhibitors (RAASi) are recommended for chronic kidney disease (CKD) patients. In this study, we describe RAASi prescription patterns in the Chronic Kidney Disease Outcomes and Practice Patterns Study (CKDopps) Brazil, Germany, France, United States (US). 5870 patients (mean age 66‐72 years; congestive heart failure [CHF] 11%‐19%; diabetes 43%‐54%; serum potassium ≥5 20%‐35%) were included. was more common Germany (80%) France (77%) than Brazil...
We investigated the effect of Post-Acute COVID Syndrome or "long-COVID" on kidney function among patients followed in post-COVID recovery clinics (PCRC) British Columbia, Canada.Long-COVID referred to PCRC between July 2020 April 2022, aged ≥18 years who had an estimated glomerular filtration rate (eGFR) value recorded at 3 months from coronavirus disease 2019 (COVID-19) diagnosis (index) date were included. Those requiring renal replacement therapy prior index excluded. Primary outcome was...
ABSTRACT Background The Kidney Failure Risk Equation (KFRE) can play a better role in vascular access (VA) planning patients with chronic kidney disease (CKD) requiring hemodialysis (HD). We described the VA creation and utilization pattern under existing estimated glomerular filtration rate (eGFR)-based referral, investigated utility of KFRE score as an adjunct variable planning. Methods Patients CKD aged ≥18 years eGFR &lt;20 mL/min/1.73 m2 who chose HD dialysis modality from January...
We investigated the long-term effect of COVID-19 on eGFR trajectory and association with progression to kidney failure in patients CKD. Patients living non-dialysis dependent CKD from British Columbia, Canada infected (cases) were matched 1:2 non-COVID-19 controls variables including pre-COVID-19 annual rate decline. followed 90 days date diagnosis. The Cox proportional hazards model was used for primary outcome defined as a composite reaching <15 ml/min/1.73m2, initiation maintenance...
Abstract Previously lacking in the literature, we describe longitudinal patterns of anemia prescriptions for non-dialysis-dependent chronic kidney disease (NDD-CKD) patients under nephrologist care. We analyzed data from 2818 Stage 3-5 NDD-CKD Brazil, Germany, and US, naïve to medications (oral iron, intravenous [IV] or erythropoiesis stimulating agent [ESA]) at enrollment CKDopps. report cumulative incidence function (CIF) medication initiation stratified by baseline characteristics. Even...
We investigated the implications of implementing race-free CKD-EPI 2021 equation among real-world CKD patients from British Columbia, Canada. This study included non-dialysis dependent aged ≥19 years who were registered in Patient Records and Outcome Management Information System (PROMIS) as March 31, 2016 (index date) with ≥1 serum creatinine measurement within 1 year prior to index date. Patients history kidney transplantation before date excluded. versus 2009 was exposure variable....
Dialysis patients have a high risk for inadequate nutrition. Their nutritional status is particularly susceptible to deterioration when faced with intercurrent events such as hospitalization. This study was conducted improve the understanding of temporal evolution parameters foundation rational and proactive intervention.
Infective endocarditis, typically caused by Gram-positive organisms such as viridans group streptococci and Staphylococcus aureus, is associated with high mortality morbidity requires aggressive, prolonged antimicrobial treatment sometimes surgery. Dalbavancin, a lipoglycopeptide active against pathogens, has long half-life, which allows IV one dose or two doses interval, offering personalized for complex psychosocial situations facilitating early discharge. In the absence of randomized...
Wastewater testing of SARS-CoV-2 has been adopted globally and shown to be a useful, non-intrusive surveillance method for monitoring COVID-19 trends. In Singapore, wastewater widely implemented across various sites facilitated timely management response. From April 2020 February 2022, RNA concentrations in monitored three populations, nationally, the community, High Density Living Environments (HDLEs) were aggregated into indices compared with reported cases hospitalisations. Temporal...