Achyut Guleri
A5015042504- Antimicrobial Resistance in Staphylococcus
- Infective Endocarditis Diagnosis and Management
- Bacterial Identification and Susceptibility Testing
- Clostridium difficile and Clostridium perfringens research
- Nosocomial Infections in ICU
- Orthopedic Infections and Treatments
- Streptococcal Infections and Treatments
- Antibiotics Pharmacokinetics and Efficacy
- Sepsis Diagnosis and Treatment
- Data-Driven Disease Surveillance
- Cardiac Valve Diseases and Treatments
- Microscopic Colitis
- Orthopaedic implants and arthroplasty
- Sinusitis and nasal conditions
- Gut microbiota and health
- Cardiac pacing and defibrillation studies
- Antibiotic Use and Resistance
- Surgical site infection prevention
- Metabolomics and Mass Spectrometry Studies
- Drug-Induced Adverse Reactions
- Infection Control in Healthcare
- Bacterial biofilms and quorum sensing
- Antifungal resistance and susceptibility
- Kawasaki Disease and Coronary Complications
- Infectious Aortic and Vascular Conditions
Mid Yorkshire Hospitals NHS Trust
2022-2023
Pinderfields Hospital
2022
University of Liverpool
2007-2022
Blackpool Victoria Hospital
2007-2022
Blackpool Teaching Hospitals NHS Foundation Trust
2012-2021
Western Infirmary
2005
BackgroundStaphylococcus aureus bacteraemia is a common cause of severe community-acquired and hospital-acquired infection worldwide. We tested the hypothesis that adjunctive rifampicin would reduce bacteriologically confirmed treatment failure or disease recurrence, death, by enhancing early S killing, sterilising infected foci blood faster, reducing risks dissemination metastatic infection.MethodsIn this multicentre, randomised, double-blind, placebo-controlled trial, adults (≥18 years)...
Dysregulated host responses to infection can lead organ dysfunction and sepsis, causing millions of global deaths each year. To alleviate this burden, improved prognostication biomarkers response are urgently needed. We investigated the use whole-blood transcriptomics for stratification patients with severe by integrating data from 3149 samples sepsis due community-acquired pneumonia or fecal peritonitis admitted intensive care healthy individuals into a gene expression reference map. used...
Sepsis, the dysregulated host response to infection causing life-threatening organ dysfunction, is a global health challenge requiring better understanding of pathophysiology and new therapeutic approaches. Here, we applied high-throughput tandem mass spectrometry delineate plasma proteome for sepsis comparator groups (noninfected critical illness, postoperative inflammation, healthy volunteers) involving 2612 samples (from 1611 patients) 4553 liquid chromatography–mass analyses acquired...
Sepsis is a clinical syndrome of life-threatening organ dysfunction caused by dysregulated response to infection, for which disease heterogeneity major obstacle developing targeted treatments. We have previously identified gene-expression-based patient subgroups (sepsis signatures [SRS]) informative outcome and underlying pathophysiology. Here, we aimed investigate the role genetic variation in determining host transcriptomic delineate regulatory networks SRS. Using genotyping RNA-sequencing...
Infective endocarditis (IE) is a complex infection associated with high mortality. Daptomycin, cyclic lipopeptide antibiotic highly active against Gram-positive bacteria, has recently been incorporated into IE treatment guidelines. This retrospective analysis provides insights the use of daptomycin in European Cubicin® Outcomes Registry Experience (EU-CORESM) between 2006 and 2010. Three hundred seventy-eight (10%) 3621 enrolled patients received for IE. Two fifty-nine (69%) had left-sided...
Infective endocarditis, typically caused by Gram-positive organisms such as viridans group streptococci and Staphylococcus aureus, is associated with high mortality morbidity requires aggressive, prolonged antimicrobial treatment sometimes surgery. Dalbavancin, a lipoglycopeptide active against pathogens, has long half-life, which allows IV one dose or two doses interval, offering personalized for complex psychosocial situations facilitating early discharge. In the absence of randomized...
The European Cubicin® Outcomes Registry and Experience (EU-CORESM) was a retrospective, non-interventional, multicenter study which evaluated the safety effectiveness of daptomycin therapy in patients with Gram-positive infections including infective endocarditis (IE). Data from EU-CORE registry were collected for IE who had received at least one dose between January 2006 April 2012, across 18 countries Europe (12), Latin America (5) Asia (1). Clinical outcomes assessed as success (cured or...
Background Staphylococcus aureus bacteraemia is a common and frequently fatal infection. Adjunctive rifampicin may enhance early S. killing, sterilise infected foci blood faster, thereby reduce the risk of dissemination, metastatic infection death. Objectives To determine whether or not adjunctive reduces bacteriological (microbiologically confirmed) failure/recurrence death through 12 weeks from randomisation. Secondary objectives included evaluating impact on all-cause mortality,...
Received 29 November 2012; returned 20 February 2013; revised 16 May accepted 18 2013 Raised vancomycin MICs have been associated with poor outcomes for methicillin-resistant Staphylococcus aureus (MRSA) bacteraemia in the USA and mainland Europe. We investigated if this also applies UK, where EMRSA-15 (clonal complex 22) dominates. Isolates from UK patients receiving therapy MRSA 2008–10 were collected, along clinical details. Outcomes (i.e. patient survival or resolution) reported 28 days...
As the recent outbreaks in Edinburgh and Camarthen, UK, have shown, Legionella pneumonia (LP) remains a significant public health problem, which is not only confined to those who travelled abroad. In both sporadic cases, diagnosis can go unrecognised. We reviewed demographics, comorbidities, diagnosis, treatment clinical outcome of LP cases over five years district general hospital northwest England. Over half were UK acquired 'classic' features common. Clinical criteria for diagnosing...
Methicillin-resistant Staphylococcus aureus (MRSA) infections represent a significant challenge. Rapid and accurate identification of MRSA in hospital admissions is essential for timely treatment decisions, isolation/bio-burden reduction reducing potential cross-transmission/acquisition these infections. Here we present the clinical benefits cost-effectiveness rapid screening programme, which was implemented at Blackpool Victoria Hospital. The economic advantages continuing service despite...
We describe an unusual case of Aspergillus fumigatus empyema and bronchopleural fistulae after extrapleural pneumonectomy (EPP) chemoradiotherapy (CRT), which was treated successfully under salvage conditions with debridement, innovative topical antifungal application supplemented systemic therapy went on for a definitive surgical procedure. Combinations CRT EPP have been recommended in select group patients malignant mesothelioma. Irrespective the combination, is associated mortality range...
European Cubicin® Outcomes Registry and Experience (EU-CORE) was a retrospective, non-interventional, multicenter registry that collected real-world clinical outcomes following daptomycin use for the treatment of Gram-positive infections. EU-CORE data from patients with infective endocarditis (IE) who underwent heart valve replacement were analysed.Clinical assessed as success (cured or improved), failure, non-evaluable. Adverse events (AEs) recorded up to 30 days after treatment.Of 610 IE,...
Background: Appendicitis is a common surgical emergency with numerous postoperative infective complications. We report an unusual case of iliac crest osteomyelitis as late complication following appendectomy for perforated gangrenous appendicitis. Methods: Review the pertinent English language literature. Results: To best our knowledge, this first in literature to describe The diagnosis was made aid magnetic resonance imaging and radioisotope bone scans. treated successfully broad-spectrum...
This study aims to demonstrate the utility of a threshold logistic approach identifying thresholds for specific antibiotic use associated with Clostridioides difficile infection (CDI) in an English teaching hospital.A combined nonlinear modeling and regression, named logistic, was used identify risk scores hospital-level hospital-onset, healthcare-associated (HOHA) CDI cases.Using regression approach, incidence greater than 0.2645 cases/1000 occupied bed-days (OBD; 85th percentile)...