A5079259216- Bone health and osteoporosis research
- Parathyroid Disorders and Treatments
- Geology and Paleoclimatology Research
- Isotope Analysis in Ecology
- Paleontology and Stratigraphy of Fossils
- Vitamin D Research Studies
- Bone health and treatments
- Marine Biology and Ecology Research
- Marine and coastal ecosystems
- Renal function and acid-base balance
- Marine Bivalve and Aquaculture Studies
- Genetic Syndromes and Imprinting
- Clay minerals and soil interactions
- Radioactive contamination and transfer
- Calcium Carbonate Crystallization and Inhibition
- Metabolism and Genetic Disorders
- Medical Imaging and Pathology Studies
- Body Composition Measurement Techniques
- Bone and Joint Diseases
- Muscle metabolism and nutrition
- Sports Performance and Training
- Methane Hydrates and Related Phenomena
- Groundwater and Isotope Geochemistry
- Geological and Geophysical Studies
GEOMAR Helmholtz Centre for Ocean Research Kiel
2011-2025
GEOMAR Technologie GmbH - GTG
2020
We assessed the potential of Calcium (Ca) isotope fractionation measurements in blood (δ44/42CaBlood) and urine (δ44/42CaUrine) as a new biomarker for diagnosis osteoporosis. One hundred post-menopausal women aged 50 to 75 years underwent dual-energy X-ray absorptiometry (DXA), gold standard determination bone mineral density. After exclusion with kidney failure vitamin D deficiency (<25 nmol/l) 80 remained study. Of these 14 fulfilled diagnostic criteria osteoporosis based on DXA. Both...
The boron isotopic ratio of 11 B/ 10 B (δ SRM951 ) and trace element composition marine carbonates are key proxies for understanding carbon cycling (pH) palaeoceanographic change. However, method validation comparability results between laboratories requires carbonate reference materials. Here, we report an inter‐laboratory comparison study to both assign δ compositions new synthetic materials (RMs), NIST RM 8301 (Coral) (Foram) assess the variance data among laboratories. Non‐certified...
Abstract Calcium supplementation before exercise attenuates the decrease in serum calcium and increase PTH bone resorption. This study investigated effect of on metabolism during load carriage women. Forty-eight women completed two sessions (load 1 n = 48; 2 40) (12.8 km 120 min carrying 20 kg) 60 after consuming either 1000 mg (Calcium) or nothing (Control) a randomised order. Pre- post-exercise urine samples were analysed for isotope ratio (δ44/42Ca). Fasted blood taken (pre-exercise), (0,...
Dysregulated calcium homeostasis is common in chronic kidney disease and causally associated with disorders of bone mineralization. However, radiological measures biomarkers do not allow accurate evaluation balance. Non-radioactive isotopes, 42Ca 44Ca, are present our diet sequestered into body compartments following principles kinetic isotope fractionation. Isotopically light preferentially incorporated bone, while heavier 44Ca excreted. The ratio (44/42Caserum) increases when formation...
ABSTRACT Serum calcium (Ca), bone biomarkers, and radiological imaging do not allow accurate evaluation of mineral balance (BMB), a key determinant density (BMD) fracture risk. We studied naturally occurring stable (non-radioactive) Ca isotopes in different body pools as potential biomarker BMB. 42Ca 44Ca are absorbed from our diet sequestered into compartments following kinetic principles isotope fractionation; isotopically light is preferentially incorporated bone, whereas heavier remains...
To further explore the clinical applicability of calcium (Ca) isotope marker (CIM), we determined
Timely and accurate diagnosis of osteoporosis is essential for adequate therapy. Calcium isotope ratio (δ44/42Ca) determination has been suggested as a sensitive, noninvasive, radiation-free biomarker the osteoporosis, reflecting bone calcium balance. The quantitative diagnostic based on calculation δ44/42Ca difference between blood, urine, bone. underlying cellular processes, however, have not studied systematically. We quantified transport fractionation during in vitro formation resorption...
Serum calcium isotopes (δ44/42Ca) have been suggested as a non-invasive and sensitive Ca balance marker. Quantitative δ44/42Ca changes associated with flux across body compartment barriers relative to the dietary correlation of δ44/42CaSerum bone histology are unknown. We analyzed by mass-spectrometry in rats after two weeks standard-Ca-diet (0.5%) four subsequent standard- low-Ca-diet (0.25%). In animals on net gain was 61 ± 3% femur content 68 41% standard-Ca-diet, mineralized area per...
Abstract Background and Aims Dysregulated mineral homeostasis is common in chronic kidney disease (CKD) associated with bone demineralization vascular calcification. The balance between formation resorption, which reflect the calcium (Ca) (BCaB), cannot be determined without biopsy invasive not easily repeatable. Recently, we have shown that stable (i.e. non-radioactive) Ca isotopes, 42Ca 44Ca, can measured serum their ratio (δ44/42Caserum) quantitatively determines net gain or loss of Ca....