A5028477834- Hormonal Regulation and Hypertension
- Estrogen and related hormone effects
- Eicosanoids and Hypertension Pharmacology
- Growth Hormone and Insulin-like Growth Factors
- Biochemical effects in animals
- Cancer, Hypoxia, and Metabolism
- Healthcare and Venom Research
- Ion Transport and Channel Regulation
- Vitamin K Research Studies
- Renin-Angiotensin System Studies
- Bee Products Chemical Analysis
- Hormonal and reproductive studies
- Blood Pressure and Hypertension Studies
- Metabolism, Diabetes, and Cancer
- Lipid metabolism and disorders
- Genomics, phytochemicals, and oxidative stress
- Sphingolipid Metabolism and Signaling
- Amoebic Infections and Treatments
- Steroid Chemistry and Biochemistry
- Free Radicals and Antioxidants
- Mechanisms of cancer metastasis
- Nuclear Receptors and Signaling
- Atherosclerosis and Cardiovascular Diseases
- Adrenal Hormones and Disorders
- Receptor Mechanisms and Signaling
Karolinska Institutet
2009-2023
University Hospital Carl Gustav Carus
2006-2016
Karolinska University Hospital
2015
Medical College of Wisconsin
2013
National Institute of Pharmaceutical Education and Research
2002-2003
Objective Adiponectin and insulin-like growth factor (IGF) binding proteins IGFBP-1 IGFBP-2 are biomarkers of insulin sensitivity. reflects sensitivity in the liver, adiponectin adipose tissue both tissues. Here, we study power adiponectin, IGFBP-1, IGFBP-2, also included IGF-I IGF-II, predicting prediabetes type 2 diabetes (T2D) men women with normal oral glucose tolerance (NGT). Design Subjects NGT (35-56 years) recruited during 1992-1998 were re-investigated 8-10 years later. In a nested...
Background and aims: Non-alcoholic fatty liver disease (NAFLD) is the most common globally. Advanced fibrosis (stage 3–4) robust marker for future mortality, but diagnosis requires biopsy. Current non-invasive scoring systems aimed to identify advanced are imperfect. Insulin-like growth factor I (IGF-I) its binding protein IGFBP-1 derived proteins, that involved in various disorders. The aim of this study was examine possible association between IGF-I NAFLD.Methods: Fasting blood samples...
IGF binding protein 1 (IGFBP1) is a member of the proteins for with an important role in glucose homeostasis. Circulating IGFBP1 derived essentially from liver where it mainly regulated negatively by insulin. Carnosine, natural antioxidant, has been shown to improve metabolic control different animal models diabetes but its mechanisms action are still not completely unraveled. We therefore investigate effect carnosine treatment on regulation db/db mice. Db/db mice and heterozygous...
Mitochondrial dysfunction in type 2 diabetes leads to oxidative stress, which drives disease progression and complications. L-carnosine, an endogenous dipeptide, improves metabolic control, wound healing kidney function animal models of diabetes. Coenzyme Q (CoQ), a component the mitochondrial electron transport chain, possesses similar protective effects on We aimed study effect carnosine CoQ, assess any synergistic CoQ improved mouse model Carnosine enhanced gene expression increased...
Objective IGF-I is a growth factor, which expressed in virtually all tissues. The circulating however derived mainly from the liver. promotes wound healing and its levels are decreased wounds with low regenerative potential such as diabetic wounds. However, contribution of to unknown. Here we investigated role systemic on rate mice deficiency liver-derived (LI-IGF-I-/- mice) during normal (normoglycemic) impaired (diabetes). Methods LI-IGF-I-/- complete inactivation gene hepatocytes were...
Adrenal blood flow (ABF) is closely coupled to steroid hormone release. ACTH and angiotensin (Ang) II stimulate cortisol aldosterone secretion; however, their effects on ABF remain poorly defined. We used the laser-Doppler technique measure rat ABF. Anesthetized male Sprague-Dawley rats were cannulated for mean arterial pressure (MAP) measurement drug infusion. The left adrenal gland was exposed measurement. MAP changes Ang determined. Bolus injections of (0.01-1000 ng/kg) increased (maximal...
Obesity, especially visceral obesity, is strongly associated with arterial hypertension. Indeed, obesity hypertension has to be considered as the most common form of essential However, exact nature relationship between and increased blood pressure remains poorly understood. Involvement renin-independent mechanisms been suggested in adrenal stimulation aldosterone secretion obese patients. This investigation examined plasma levels renin, aldosterone, insulin, HDL LDL hypertensive normotensive...
Alterations in both vasculature and renin-angiotensin-aldosterone system are a consistent finding the metabolic syndrome. Adrenal tissue is highly vascularized encounters blood flow, exceeding by far volume expected for its size. Endothelial cells adrenal therefore major cellular component of adrenocortical tissue. The aim study was to analyze interaction between endothelial steroid producing cells, focusing on cell-factor-mediated activation aldosterone synthesis. human (HUVECs)...
Modification of low-density lipoprotein (LDL) and abnormal aldosterone cortisol metabolism have been implicated in the pathogenesis type 2 diabetes (DM2) diabetic vascular disease. Since LDL serves as a major cholesterol source for adrenal steroidogenesis, we investigated whether modification prediabetic subjects influences adrenocortical release. was isolated from 30 with normal glucose tolerance (NGT-LDL), impaired (IGT-LDL), 26 patients DM2 (DM2-LDL). Oxidation glycoxidation...
Serum aldosterone is a causative factor for various metabolic and cardiovascular disorders. Low-density lipoprotein (LDL) major cholesterol source steroidogenesis; however, the effect of oxidative modification LDL on release not known. We studied hypochlorite-oxidized (oxLDL) adrenal secretion.LDL (native (natLDL)) was obtained from healthy volunteers oxidatively modified in vitro. NCI-H295R cells were stimulated with natLDL oxLDL, quantified by radioimmunoassay. Molecular changes western...
The endothelium releases factors stimulating the adrenal cortex. It is also known that endothelin-1 (ET-1) promotes generation of cortisol and aldosterone, proliferation adrenocortical cells. aim study was to find out whether effect on cells dominated by action ET-1. effects endothelial cell-conditioned medium (ECCM), obtained during growth human umbilical cord vein cells, aldosterone release cancer cell-line NCI-H295R promoter activity steroidogenic acute-regulatory protein (StAR) were...
Endothelial cells have been shown to induce adrenal steroidogenesis and enhance aldosterone secretion via angiotensin II endothelin 1-independent mechanisms. It has demonstrated that endothelial adrenocortical are capable of producing interleukin-6 (IL-6) IL-6 is a factor known stimulate cortisol secretion. We therefore asked whether an effect on generation mediates biosynthesis as observed after exposure cell-conditioned medium (ECCM). Cells from the cancer cell line NCI-H295R were...
Endothelial cells play an important role in the development and functioning of endocrine tissue. They populate adrenal cortex as a part capillaries sinusoids that engulf groups steroidogenic cells. This arrangement enables sufficient paracrine interaction between endothelial Moreover, various cell-derived factors have been known to regulate mineralocorticoid release. In present study, we analyzed human synthesis release aldosterone from adrenocortical (NCI-H295R).