A5029668625- Dialysis and Renal Disease Management
- Health Systems, Economic Evaluations, Quality of Life
- Renal Transplantation Outcomes and Treatments
- Renal Diseases and Glomerulopathies
- Cell Adhesion Molecules Research
- Blood Coagulation and Thrombosis Mechanisms
- Central Venous Catheters and Hemodialysis
- Organ Donation and Transplantation
- Atrial Fibrillation Management and Outcomes
- Venous Thromboembolism Diagnosis and Management
- Healthcare cost, quality, practices
- Radiation Dose and Imaging
- Microbial metabolism and enzyme function
- Motor Control and Adaptation
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Hernia repair and management
- Neural and Behavioral Psychology Studies
- Cardiac and Coronary Surgery Techniques
- Diabetes Treatment and Management
- Ultrasound in Clinical Applications
- Fungal Infections and Studies
- Bone and Dental Protein Studies
- Lung Cancer Treatments and Mutations
- Renal and Vascular Pathologies
- Signaling Pathways in Disease
University of Toronto
2020-2024
Sunnybrook Health Science Centre
2023-2024
Health Sciences Centre
2023-2024
Toronto General Hospital
2020-2021
SickKids Foundation
2021
Wellcome Centre for Cell-Matrix Research
2021
University Health Network
2020-2021
St. Michael's Hospital
2020
National Guard Health Affairs
2017
King Abdulaziz Medical City
2016-2017
This study investigated the association of intra-abdominal adhesions with risk peritoneal dialysis (PD) catheter complications. Individuals undergoing laparoscopic PD insertion were prospectively enrolled from eight centers in Canada and United States. Patients grouped based on presence observed during insertion. The primary outcome was composite never starting, termination PD, or need for an invasive procedure caused by flow restriction abdominal pain. Seven hundred fifty-eight individuals...
Colistin therapy is associated with the development of nephrotoxicity. We examined incidence and risk factors nephrotoxicity colistin dosing. included adult hospitalized patients who received intravenous (IV) for >72 h between January 2014 December 2015. The primary endpoint was colistin-associated acute kidney injury (AKI). secondary analyses were predictors nephrotoxicity, proportions inappropriately dosed according to Food Drug Administration (FDA), European Medicines Agency (EMA),...
As more people survive into old age, a greater number are becoming eligible for dialysis treatment end-stage renal failure. In the UK elderly have previously been excluded from programmes, and continuing financial constraints unlikely to improve this situation. There few data on views of subjects replacement treatment. We have, therefore, explored in study.50 were selected hospital geriatric wards nursing homes. A short clinical vignette about 75-year-old patient with failure was presented,...
Visuomotor abnormalities are common in aging and age-related disease, yet difficult to quantify. This study investigated the effects of healthy aging, sex, handedness on performance a tracing task. Participants (n = 150, aged 21–95 years, 75 females) used stylus follow moving target around circle tablet computer with their dominant nondominant hands. also performed Trail Making Test (a measure executive function). Deviations from circular path were computed derive an “error” time series. For...
In Saudi Arabia, only 9% of dialysis patients are on peritoneal (PD), and this has been the case for years. A number centers around world have sought to understand underutilization PD by asking nephrologists directly. study, we aimed gather information that will answer question “Why is underutilized in Arabia?” hoping a roadmap may be developed overcome hurdles study underscores, allowing more utilize valuable modality.
Incremental peritoneal dialysis (PD) offers patients newly starting less than the standard "full dose" of PD, reducing treatment burden and intrusiveness while minimizing symptoms renal failure. PD is a cost-effective approach that has been associated with slower rates decline in residual kidney function. This also produces waste turn reduces environmental footprint compared to prescriptions. It aligns International Society Peritoneal Dialysis (ISPD) Practice Recommendations for...
Over a ten-year period we have studied 75 cases of adult acute lymphoblastic leukaemia (ALL). Sixty the were seen from 1979 to 1984 and represent an unselected series all known in region 3 000 people. Study these patients has given further insight into heterogeneous, clinical cytological nature ALL. Three protocols been used results are presented indicating that conventional approaches treatment this disease unsatisfactory. Not could be entered on but included give overall perspective...
Objective: The objective of the study was to determine whether ideational apraxia (IA), a loss ability plan sequence actions needed achieve goal, is associated with Parkinson disease (PD). Background: frontal lobes play an important role in planning and sequencing, many patients PD have lobe dysfunction. Methods: Ten right-handed 10 neurologically psychiatrically healthy people participated. To assess for IA, participants were given sets pictures that showed steps completing task, but shown...
Despite the fact that many of medical outcome data peritoneal dialysis (PD) have been improving over past few years, PD remains an underutilized modality in countries worldwide. Most nephrologists those report a high rate patients' refusal. We conducted this survey-based study to determine obstacles behind underutilization Saudi Arabia from perspectives and understand reasons for their Nine-hundred twenty hemodialysis (HD) patients, who had never on before, participated study. Responses...
Abstract Background Focal and segmental glomerulosclerosis (FSGS) is a histologic pattern of injury that characterizes wide spectrum diseases. Many genetic causes have been identified in FSGS but even families with comprehensive testing, significant proportion remain unexplained. Methods In family adult-onset autosomal dominant FSGS, linkage analysis was performed 11 members followed by whole exome sequencing (WES) 3 affected relatives to identify candidate genes. Results Pathogenic variants...
Podocyte dysfunction is the main pathologic mechanism driving development of FSGS and other morphologic types steroid-resistant nephrotic syndrome (SRNS). Despite significant progress, genetic causes most cases SRNS have yet to be identified.
Blood group incompatibility (ABOi) is the most common barrier to living donor kidney transplantation. Options for such recipients include paired donation (KPD) or desensitization methodology reduce blood antibody response.The objective of this study report on first North America experience in ABOi transplantation using Glycosorb ABO immunoadsorption columns.Retrospective observational cohort study.Renal transplant program at St. Michael's Hospital, Unity Health Toronto, University...
It occurs because of acute or chronic dysfunction in one organ leading to the other. Underlying mechanisms include arterial under-filling, neurohormonal activation, venous congestion and endothelial dysfunction.[1][1] Around 60% patients with decompensated heart failure have
Heparin has been shown to enhance ADP-induced platelet aggregation in patients undergoing cardiopulmonary bypass surgery. This effect appears be maximal throughout the initial 30 minutes of systemic heparinization and once reached is maintained procedure. The prebypass state regained following heparin reversal by protamine sulphate. It possible that this on function may contribute towards some microembolization phenomena seen
A patient with nephrotic syndrome of unknown aetiology was found to have a grossly prolonged prothrombin time in the absence any other coagulation abnormality and no clinical bleeding problem. Subsequent investigations showed his plasma contained an inhibitor-like substance, directed against human but not animal thromboplastin.
The objective of this study was to determine adherence the 2010 Consolidated Standards Reporting Trials (CONSORT) standards for reported randomized controlled trials (RCTs) assessing immunosuppressive medications in kidney transplant population between 2007 and 2013. period divided into two arms, 2007-2010 2010-2013. RCTs were extracted from 3 major databases, CONSORT evaluated using score. Of 540 extracted, 110 selected study, comprising 55 each period. median score 17. Significant...
[Voir la version anglaise de l’article ici: www.cmaj.ca/lookup/doi/10.1503/cmaj.230226][1] Il est causé par une dysfonction chronique ou aigüe dans 1 ces 2 organes, qui entraîne l’autre. Parmi les mécanismes le sous-tendent, on compte sous-remplissage artériel