A5087775718- SARS-CoV-2 and COVID-19 Research
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Neuroscience and Neuropharmacology Research
- Amino Acid Enzymes and Metabolism
- Hematological disorders and diagnostics
- COVID-19 Clinical Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- COVID-19 and healthcare impacts
- Ubiquitin and proteasome pathways
- Parkinson's Disease Mechanisms and Treatments
- Neuroendocrine Tumor Research Advances
- Tryptophan and brain disorders
- Biomedical Research and Pathophysiology
- Nuclear Receptors and Signaling
- Immunodeficiency and Autoimmune Disorders
- Long-Term Effects of COVID-19
- Drug-Induced Adverse Reactions
- Receptor Mechanisms and Signaling
- Botulinum Toxin and Related Neurological Disorders
- Lung Cancer Research Studies
- Photoreceptor and optogenetics research
- Pain Management and Treatment
- Osteomyelitis and Bone Disorders Research
- Histone Deacetylase Inhibitors Research
Antwerp University Hospital
2021-2025
Netherlands Comprehensive Cancer Organisation
2024
Vrije Universiteit Brussel
1986-2022
University of Antwerp
2021
Geneeskundige en Gezondheidsdienst
2016-2019
Pharmac
2018
Universitair Ziekenhuis Brussel
1987-2012
Statistics Belgium
1996
Cancer patients are at a higher risk of developing severe coronavirus disease 2019 (COVID-19). However, the safety and efficacy COVID-19 vaccination in cancer undergoing treatment remain unclear.In this interventional prospective multicohort study, priming booster doses BNT162b2 vaccine were administered 21 days apart to solid tumor receiving chemotherapy, immunotherapy, targeted or hormonal therapy, with hematologic malignancy rituximab after allogeneic hematopoietic stem cell...
Gastroenteropancreatic neuroendocrine neoplasms(GEP NEN) exhibit substantial biological heterogeneity, impacting clinical management and outcomes. In 2019, the WHO introduced tumour(NET) grade 3 (G3) subgroup, characterized by Ki-67>20% a well-differentiated morphology poorly differentiated carcinomas(NEC) (Ki-67>20%). Since this update, questions about prognostic implications best treatment strategies for NET G3 NEC remain. Therefore we initiated real-world retrospective observational...
The level of protection against SARS-CoV-2 breakthrough infections conferred by the presence anti-S1 antibodies (IgGs) in cancer patients is still understudied. This work examines existence an immunoglobulin G (IgG) -based correlate (CoP) established prospectively collected observational data about with different variants a large cohort study vaccinated patients. 760 were longitudinally followed-up, starting before first vaccination until six months after second booster. Anti-S1 IgGs...
Abstract The astrocytic cystine/glutamate antiporter system x c − represents an important source of extracellular glutamate in the central nervous system, with potential impact on excitatory neurotransmission. Yet, its function and importance brain physiology remain incompletely understood. Employing slice electrophysiology mice a genetic deletion specific subunit , xCT (xCT −/− mice), we uncovered decreased neurotransmission at corticostriatal synapses. This effect was partly mitigated by...
Abstract Introduction: Long COVID is defined as the continuation of symptoms, unexplainable by alternative diagnosis, longer than four weeks after SARS-CoV-2 infection. These symptoms might hinder daily activities and overall well-being, ultimately impacting quality life (QoL). Several studies have reported fatigue most common symptom, followed dyspnoea, headache myalgia. Although it assumed that long affects 10–20% infected individuals, recently numbers up to 60% were described for patients...
Multiple sclerosis (MS) is an autoimmune demyelinating disease that affects the central nervous system (CNS), leading to neurodegeneration and chronic disability. Accumulating evidence points a key role for neuroinflammation, oxidative stress, excitotoxicity in this degenerative process. System xc − or cystine/glutamate antiporter could tie these pathological mechanisms together: its activity enhanced by reactive oxygen species inflammatory stimuli, enhancement might lead release of toxic...
Purpose: Patients with cancer display reduced humoral responses after double-dose COVID-19 vaccination, whereas their cellular response is more comparable that in healthy individuals. Recent studies demonstrated a third vaccination dose boosts these immune responses, both people and patients cancer. Because of the availability many different vaccines, have been boosted vaccine from one used for vaccination. Data on such alternative schedules are scarce. This prospective study compares...
Abstract The cystine/glutamate antiporter system x c − has been identified as the major source of extracellular glutamate in several brain regions well a modulator neuroinflammation, and genetic deletion its specific subunit xCT (xCT −/− ) is protective mouse models for age-related neurological disorders. However, previously observed oxidative shift plasma cystine/cysteine ratio adult mice led to hypothesis that would negatively affect life- healthspan. Still, till now role physiological...
Despite ample evidence for the therapeutic potential of inhibition cystine/glutamate antiporter system x c − in neurological disorders and cancer, none proposed inhibitors is selective. In this context, a lot research has been performed using EMA- FDA-approved drug sulfasalazine (SAS). Even though molecule already on market decades as an anti-inflammatory drug, serious side effects due to its use have reported. Whereas treatment main indications, SAS needs be cleaved intestine into compound...
The astrocytic cystine/glutamate antiporter system x c - (with xCT as the specific subunit) imports cystine in exchange for glutamate and has been shown to interact with multiple pathways brain that are dysregulated age-related neurological disorders, including homeostasis, redox balance, neuroinflammation. In current study, we investigated effect of genetic deletion on lactacystin (LAC)- 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced degeneration nigrostriatal pathway, models...
Background: Currently, nanoliposomal irinotecan (nal-IRI) + 5-fluorouracil/folinic acid (5-FU/LV) is the only approved second-line treatment for patients suffering from metastatic pancreatic ductal adenocarcinoma (mPDAC). However, also other chemotherapeutic regimens are used in this setting and due to lack of clear real-world data on efficacy different regimens, there no consensus optimal sequence mPDAC patients. Objectives: To provide information safe efficacious use nal-IRI 5-FU/LV...
Erdheim-Chester disease (ECD) is a rare non-Langerhans’ cell histiocytosis. Mild but permanent juxta-articular bone pain in mainly knees and ankles the most frequent associated symptom. Despite pathognomonic radiographic findings, cases are still diagnosed by pathologist. The lesions consist of lipid-storing CD 68 +/ 1a – non- Langerhans’ histiocytes, frequently localized also involving multiple organ systems body. We present case report which diagnosis ECD was established with 99mTc MDP SPECT/CT.
Proper glutamatergic neurotransmission requires a balance between glutamate release and removal. The removal is mainly catalyzed by the transporters EAAT1-3, while glutamate-cystine exchanger (system xc− with specific subunit xCT) represents one of mechanisms. Previous studies spinal cord have focused on cellular distribution EAAT1-3 special reference to dorsal horn, but not provided quantitative data systematically compared multiple segments. Here we studied xCT in sections segments using...
Patients with cancer, especially hematological are at increased risk for breakthrough COVID-19 infection. So far, a predictive biomarker that can assess compromised vaccine-induced anti-SARS-CoV-2 immunity in cancer patients has not been proposed. We employed machine learning approaches to identify signature based on blood cytokines, chemokines, and immune- non-immune-related growth factors linked vaccine immunogenicity 199 receiving the BNT162b2 vaccine. C-reactive protein (general marker...