A5061723479- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Vestibular and auditory disorders
- Memory and Neural Mechanisms
- Hearing, Cochlea, Tinnitus, Genetics
- Receptor Mechanisms and Signaling
- Ion channel regulation and function
- Cholinesterase and Neurodegenerative Diseases
- Neurogenesis and neuroplasticity mechanisms
- Neurobiology and Insect Physiology Research
- Immune cells in cancer
- Amino Acid Enzymes and Metabolism
- Musculoskeletal pain and rehabilitation
- Anesthesia and Neurotoxicity Research
- S100 Proteins and Annexins
- Autoimmune Neurological Disorders and Treatments
- Cellular Mechanics and Interactions
- Retinal Development and Disorders
- Neural dynamics and brain function
- Protein Kinase Regulation and GTPase Signaling
- Phosphodiesterase function and regulation
- French Urban and Social Studies
- Pain Mechanisms and Treatments
- Photoreceptor and optogenetics research
University of Mons
2016-2025
University of Kinshasa
2021
Fundación Juan March
2007
In-Q-Tel
2007
University College London
2003-2005
Society for Neuroscience
2003
King's College Hospital
2001
Fund for Scientific Research
1999
École Normale Supérieure - PSL
1999
Centre National de la Recherche Scientifique
1999
In the brain of Alzheimer9s disease (AD) patients, neurotoxic amyloid peptides accumulate and are deposited as senile plaques. A major therapeutic strategy aims to decrease production by inhibition γ-secretase. Presenilins polytopic transmembrane proteins that essential for γ-secretase activity during development in production. By loxP/Cre-recombinase-mediated deletion, we generated mice with postnatal, neuron-specific presenilin-1 (PS1) deficiency, denoted PS1(n−/−), were viable fertile,...
1. Neuronal activity was investigated in the left superior vestibular nucleus (SVN), lateral (LVN), and rostral part of medial (MVN) alert guinea pig after a unilateral (left) labyrinthectomy performed. Vestibular neurons were recorded either immediately (just-postoperative group, n = 6) or 1 wk (1-wk-postoperative compared with intact animals (control 6). 2. Animals prepared for extracellular recording single-unit eye movement (scleral search coil technique). To enable stimulation nerve,...
Prion-like seeding and propagation of Tau-pathology have been demonstrated experimentally may underlie the stereotyped progression neurodegenerative Tauopathies. However, involvement templated misfolding Tau in neuronal network dysfunction behavioral outcomes remains to be explored detail. Here we analyzed repercussions prion-like spreading via connections on function TauP301S transgenic mice. Spontaneous GABAAR-antagonist-induced activity were affected following Tau-misfolding using...
In the guinea pig, a unilateral labyrinthectomy is followed by an initial depression and subsequent restoration of spontaneous activity in neurons ipsilateral vestibular nuclei. two previous works, we have established time course these changes alert pig using electrical stimulation as search stimulus to select analyzed neurons. The latter criterion was important capture many that are silent at rest during immediate postlabyrinthectomy stage. Because it known pathway originating from nuclei...
Long-term memory (LTM) formation has been linked with functional strengthening of existing synapses and other processes including de novo synaptogenesis. However, it is unclear whether synaptogenesis can contribute to LTM formation. Here, using α-calcium/calmodulin kinase II autophosphorylation-deficient (T286A) mutants, we demonstrate that when severely impaired, contextual training-induced PSD95 up-regulation followed by persistent generation multiinnervated spines, a type synapse...
Clinical practice guidelines promote bio-psychosocial management of patients suffering from low back pain (LBP). The objective this study was to examine the current knowledge, attitudes and beliefs physiotherapists about a guideline-adherent approach LBP assess ability recognise signs specific in clinical vignette.Physiotherapists were recruited participate an online study. They asked indicate whether they familiar with evidence-based then fill Health Care Providers' Pain Impairment...
Mutant human presenilin-1 (PS1) causes an Alzheimer's-related phenotype in the brain of transgenic mice combination with mutant amyloid precursor protein by means increased production peptides (Dewachter, I., Van Dorpe, J., Smeijers, L., Gilis, M., Kuiperi, C., Laenen, Caluwaerts, N., Moechars, D., Checler, F., Vanderstichele, H. & Leuven, F. (2000) <i>J. Neurosci.</i> 20, 6452–6458) that aggravate plaques and cerebrovascular (Van Dewachter, Nuyens, Spittaels, K., van den Haute, Mercken,...
Unilateral labyrinthectomy results in oculomotor and postural disturbances that regress a few days during vestibular compensation. The long-term (after 1 mo) consequences of unilateral were investigated by characterizing the static dynamic membrane properties ipsilesional neurons recorded intracellularly guinea pig brain stem slices. We compared responses type A B medial nucleus identified vitro to current steps ramps sinusoidal currents various frequencies. All depolarized 6–10 mV at rest...
Long-term memory (LTM) requires activation of the transcription factor cAMP-responsive element binding protein (CREB). Signaling by Ca2+/calmodulin (CaM) kinase cascade has been implicated in CREB and consolidation processes hippocampus. The CaM beta isoforms belong to cascade, we have generated null mutant mice investigate role these kinases several forms learning memory. mutants were impaired spatial training-induced formation. Furthermore, lacked late, but not early, long-term...
1. In the guinea‐pig, a unilateral labyrinthectomy induces postural disturbances and an ocular nystagmus which abate or disappear over time. These behavioural changes are accompanied by initial collapse subsequent restoration of spontaneous activity in neurones ipsilateral vestibular nuclei. Recently, it has been shown that neuronal remained collapsed at least 10 h whereas its was complete 1 week after lesion. The aims this study were to determine when partially deafferented started compare...
Nowadays, nanoparticles (NPs) of titanium dioxide (TiO2) are abundantly produced. TiO2 NPs present in various food products, paints, cosmetics, sunscreens and toothpastes. However, the toxicity on central nervous system has been poorly investigated until now. The aim this study was to evaluate vitro vivo. In cell cultures derived from embryonic cortical brain rats, a significant decrease neuroblasts observed after 24 96 h incubation with (5 20 μg/ml). This phenomenon resulted an inhibition...
Tau alterations are now considered an executor of neuronal demise and cognitive dysfunction in Alzheimer's disease (AD). Mouse models combining amyloidosis tauopathy their parental counterparts important tools to further investigate the interplay abnormal amyloid-β (Aβ) species pathogenesis, synaptic dysfunction, decline. Here, we crossed APP/PS1 mice with 5 early-onset familial AD mutations (5xFAD) TauP301S (PS19) transgenic mice, denoted F+/T+ phenotypically compared them respective...
Abstract The astrocytic cystine/glutamate antiporter system x c − represents an important source of extracellular glutamate in the central nervous system, with potential impact on excitatory neurotransmission. Yet, its function and importance brain physiology remain incompletely understood. Employing slice electrophysiology mice a genetic deletion specific subunit , xCT (xCT −/− mice), we uncovered decreased neurotransmission at corticostriatal synapses. This effect was partly mitigated by...
Despite the recommendations to use a bio-psycho-social framework, many physiotherapists still manage their patients mainly from biomedical point of view. The purpose this study is analyze impact two different e-learning interventions on knowledge, attitudes, and clinical decision-making managing low back pain (LBP) increase guideline-consistent care. Physiotherapists were allocated (1/1) either an experimental or traditional intervention. Baseline post-intervention assessment included Health...
Abstract During somatosensory neurogenesis, neurons are born in an unspecialized transcriptional state. Several transcription factors these cells follow a broad-to-restricted expression trajectory as development proceeds, giving rise to neuron subtypes with different identities. The relevance of this temporal refinement factor remains unclear the functions patterns have been mostly studied those which they remain active. Here we show that Dach1 encodes bona fide pattern retained and required...
Current thinking about LTP triggered in the area CA1 of hippocampal slices is ruled by two “dogmas”: (1) A single train high-frequency stimulation sufficient to trigger short-lasting (1 – 3 h), whereas multiple trains are required induce long-lasting (L-LTP, more than 4 h). (2) The development late phase L-LTP requires synthesis new proteins. In this study, we found that a could an lasting 8 h was not affected either anisomycin or cycloheximide (two inhibitors protein synthesis). We...
Abstract Background GSK3β is involved in a wide range of physiological functions, and presumed to act the pathogenesis neurological diseases, from bipolar disorder Alzheimer’s disease (AD). In contrast, GSK3α isozyme remained largely ignored with respect both aspects. Results We generated characterized two mouse strains neuron-specific or total deficiency. Behavioral electrophysiological analysis demonstrated importance neuronal GSK3α, not compensating for impaired cognition reduced LTP....
In neurons, the Ca(2+)/calmodulin (CaM) kinase cascade transduces Ca(2+) signaling into gene transcription. The CaM is known to be important for brain development as well memory formation in adult brain, although functions of some members remain unknown. Here we have generated null and hypomorphic mutants study physiological role alpha (CaMKKalpha), which phosphorylates activates both I (CaMKI) CaMKIV, output kinases cascade. We show that CaMKKalpha dispensable long-term potentiation...
The development of the cerebral cortex is a tightly regulated process that relies on exquisitely coordinated actions intrinsic and extrinsic cues. Here, we show communication between forebrain meninges apical neural progenitor cells (aNPC) essential to cortical development, basal compartment aNPC key this process. We found Celsr1, cadherin adhesion G protein coupled receptor family, controls branching processes abutting thereby regulates retinoic acid (RA)-dependent neurogenesis....