A5053622487- Neurobiology and Insect Physiology Research
- Erythrocyte Function and Pathophysiology
- Axon Guidance and Neuronal Signaling
- Hearing, Cochlea, Tinnitus, Genetics
- Cancer-related molecular mechanisms research
- Hereditary Neurological Disorders
- Ion channel regulation and function
- Pain Mechanisms and Treatments
- Neurogenesis and neuroplasticity mechanisms
- Classical Philosophy and Thought
- Pediatric Pain Management Techniques
- Hemispheric Asymmetry in Neuroscience
- Neural dynamics and brain function
- Congenital heart defects research
- Neuroendocrine regulation and behavior
- Zebrafish Biomedical Research Applications
- Genetics and Neurodevelopmental Disorders
- Historical, Literary, and Cultural Studies
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Pain Management and Placebo Effect
- Cellular Mechanics and Interactions
- Developmental Biology and Gene Regulation
- Olfactory and Sensory Function Studies
- Pharmacological Effects and Toxicity Studies
Université Libre de Bruxelles
2015-2025
Université de Montpellier
2019-2024
Institute for Neurosciences of Montpellier
2019-2024
Inserm
2019-2024
École Normale Supérieure de Lyon
2023-2024
Centre National de la Recherche Scientifique
2023-2024
Institut de Génomique Fonctionnelle de Lyon
2023-2024
Distinct subfamilies of proneural bHLH transcription factors (TFs) control neurogenesis and influence neuronal fate specification throughout the developing nervous system. While members different generally display divergent expression functions, those within same subfamily are often co-expressed, raising questions about their respective roles. Here, we assess functional equivalence two paralogous TFs Neurog1 Neurog2, focusing on neurons dorsal root ganglia (DRG) which underlie our ability to...
Abstract During somatosensory neurogenesis, neurons are born in an unspecialized transcriptional state. Several transcription factors these cells follow a broad-to-restricted expression trajectory as development proceeds, giving rise to neuron subtypes with different identities. The relevance of this temporal refinement factor remains unclear the functions patterns have been mostly studied those which they remain active. Here we show that Dach1 encodes bona fide pattern retained and required...
V1 interneurons are inhibitory neurons that play an essential role in vertebrate locomotion. The molecular mechanisms underlying their genesis remain, however, largely undefined. Here, we show the transcription factor Prdm12 is selectively expressed p1 progenitors of hindbrain and spinal cord frog embryo, a similar restricted expression profile observed nerve other vertebrates as well cephalochordate amphioxus. Using frog, chick mice, analyzed regulation found its caudal neural tube...
Ribosomes are essential nanomachines responsible for protein production. Although ribosomes present in every living cell, ribosome biogenesis dysfunction diseases, called ribosomopathies, impact particular tissues specifically. Here, we evaluate the importance of box C/D snoRNA-associated ribosomal RNA methyltransferase fibrillarin (Fbl) early embryonic development Xenopus laevis . We report that developing embryos, neural plate, crest cells (NCCs), and NCC derivatives rich fbl transcripts....
Touch sensation is primarily encoded by mechanoreceptors, called low-threshold mechanoreceptors (LTMRs), with their cell bodies in the dorsal root ganglia. Because of great diversity terms molecular signature, terminal endings morphology, and electrophysiological properties, mirroring complexity tactile experience, LTMRs are a model choice to study cues differentially controlling neuronal diversification. While transcriptional codes that define different LTMR subtypes have been extensively...
Functionally distinct classes of dorsal root ganglia (DRG) somatosensory neurons arise from neural crest cells (NCCs) in two successive phases differentiation assumed to be respectively and independently controlled by the proneural genes Neurog2 Neurog1. However, precise role during this process remains unclear, notably because no neuronal loss has been reported hitherto Neurog2-/- mutants. Here, we show that at trunk levels, deficiency impairs production subsets all DRG neuron subtypes. We...
Highlights•Loss of Prdm12 induces Bax-dependent apoptosis in developing somatosensory ganglia•Prdm12 represses the visceral determinants Phox2a/b ganglia•Repression by is time and context dependent•Visceral fate switch surviving ectopic cell incompleteSummaryPrdm12 a transcriptional regulator essential for emergence somatic nociceptive lineage during sensory neurogenesis. The exact mechanisms which promotes nociceptor development remain, however, poorly understood. Here, we report that...
Prdm12 is a conserved epigenetic transcriptional regulator that displays restricted expression in nociceptors of the developing peripheral nervous system. In mice, required for development entire nociceptive lineage. humans, PRDM12 mutations cause congenital insensitivity to pain, likely because loss nociceptors. maintained mature suggesting yet-to-be explored functional role adults. Using inducible conditional knockout mouse models, we report adult no longer cell survival but continues play...
Abstract Touch sensation is primarily encoded by mechanoreceptors, called Low-Threshold Mechanoreceptors (LTMRs), with their cell bodies in the Dorsal Root Ganglia (DRG). Because of great diversity terms molecular signature, terminal endings morphology and electrophysiological properties, mirroring complexity tactile experience, LTMRs are a model choice to study cues differentially controlling neuronal diversification. While transcriptional codes that define different LTMR subtypes have been...
Abstract Prdm12 is an epigenetic regulator expressed in developing and mature nociceptive neurons, playing a key role their specification during neurogenesis modulating pain sensation at adulthood. In vitro studies suggested that recruits the methyltransferase G9a through its zinc finger domains to regulate target gene expression, but how interacts with whether plays Prdm12’s functional properties sensory ganglia remain unknown. Here we report Prdm12-G9a interaction likely direct it involves...
Touch sensation is primarily encoded by mechanoreceptors, called Low-Threshold Mechanoreceptors (LTMRs), with their cell bodies in the Dorsal Root Ganglia (DRG). Because of great diversity terms molecular signature, terminal endings morphology and electrophysiological properties, mirroring complexity tactile experience, LTMRs are a model choice to study cues differentially controlling neuronal diversification. While transcriptional codes that define different LTMR subtypes have been...
Touch sensation is primarily encoded by mechanoreceptors, called low-threshold mechanoreceptors (LTMRs), with their cell bodies in the dorsal root ganglia. Because of great diversity terms molecular signature, terminal endings morphology, and electrophysiological properties, mirroring complexity tactile experience, LTMRs are a model choice to study cues differentially controlling neuronal diversification. While transcriptional codes that define different LTMR subtypes have been extensively...
Summary During somatosensory neurogenesis, neurons are born in an unspecialized transcriptional state, with several transcription factors following a broad-to-restricted expression dynamic as development proceeds, supporting neuron subtype identities. The relevance of this temporal refinement remains however unclear, these being selectively involved which they ultimately maintained. Here we found that Dach1 encodes for bona fide factor retained and required tactile neurons. Within developing...
Functionally distinct classes of dorsal root ganglia (DRG) somatosensory neurons arise from neural crest cells (NCCs) during two successive phases differentiation assumed to be respectively controlled by the proneural genes Neurog2 and Neurog1. However, individual requirement in this system still remains unclear notably since no neuronal loss has been reported hitherto Neurog2-/- mutants. Here, we reveal that at thoracic levels, Neurog2-deficiency generally impairs formation subsets all...
ABSTRACT Ribosomes are essential nanomachines responsible for protein production. Although ribosomes present in every living cell, ribosome biogenesis dysfunction diseases, called ribosomopathies, impact particular tissues specifically. Here, we evaluate the importance of box C/D snoRNA-associated ribosomal RNA methyltransferase fibrillarin (Fbl) early embryonic development Xenopus laevis . We report that developing embryos, neural plate, crest cells (NCCs), and NCC derivatives rich fbl...
ABSTRACT Prdm12 is an epigenetic regulator expressed in developing and mature nociceptive neurons, playing a key role their specification during neurogenesis modulating pain sensation at adulthood. In vitro studies suggested that recruits the methyltransferase G9a through its zinc finger domains to regulate target gene expression, but how interacts with whether plays Prdm12’s functional properties sensory ganglia remain unknown. Here we report SET domain of necessary sufficient for...
Touch sensation is primarily encoded by mechanoreceptors, called Low-Threshold Mechanoreceptors (LTMRs), with their cell bodies in the Dorsal Root Ganglia. Because of great diversity terms molecular signature, terminal endings morphology and electrophysiological properties, mirroring complexity tactile experience, LTMRs are a model choice to study cues differentially controlling neuronal diversification. While transcriptional codes that define different LTMR subtypes have been extensively...