A5066024296- Ion channel regulation and function
- Neurobiology and Insect Physiology Research
- Erythrocyte Function and Pathophysiology
- Pain Mechanisms and Treatments
- Hearing, Cochlea, Tinnitus, Genetics
- Tactile and Sensory Interactions
- Pediatric Pain Management Techniques
- Classical Philosophy and Thought
- Vestibular and auditory disorders
- Chemical and Physical Studies
- Historical, Literary, and Cultural Studies
- Hemispheric Asymmetry in Neuroscience
- Neural dynamics and brain function
- Transcranial Magnetic Stimulation Studies
- Cellular transport and secretion
- Anesthesia and Pain Management
- Planarian Biology and Electrostimulation
- Neuroscience and Neural Engineering
- Language, Metaphor, and Cognition
- Neuroscience of respiration and sleep
- Muscle activation and electromyography studies
- Musculoskeletal pain and rehabilitation
- Sleep and Wakefulness Research
- Anesthesia and Neurotoxicity Research
- Neuroendocrine regulation and behavior
Max Delbrück Center
2020-2024
Institut de Génomique Fonctionnelle de Lyon
2023-2024
École Normale Supérieure de Lyon
2023-2024
Centre National de la Recherche Scientifique
2023-2024
Institute for Neurosciences of Montpellier
2023-2024
Inserm
2023-2024
Université de Montpellier
2023-2024
University College London
2014-2017
Great Ormond Street Hospital for Children NHS Foundation Trust
2015
Abstract PIEZO2 is a trimeric mechanically-gated ion channel expressed by most sensory neurons in the dorsal root ganglia. Mechanosensitive channels are also genetically required for normal touch sensation both mice and humans. We previously showed that strongly modulated membrane voltage. Specifically, it only at very positive voltages all available opening mechanical force. Conversely, blocked negative resting potentials. The physiological function of this unusual biophysical property...
Neonatal surgical injury triggers developmentally regulated long-term changes that include enhanced hyperalgesia and spinal microglial reactivity after reinjury. To further evaluate priming of response by neonatal hindpaw incision, the authors investigated functional role p38 mitogen-activated protein kinase reincision in adult rodents.Plantar incision was performed anesthetized rats, with or without previous on postnatal day 3. Numbers distribution phosphorylated-p38 (1, 3, 24 h)...
In Brief The rostroventral medial medulla (RVM) is part of a rapidly acting spino-bulbo-spinal loop that activated by ascending nociceptive inputs and drives descending feedback modulation spinal nociception. the adult rat, RVM can facilitate or inhibit dorsal horn neuron but in young animals facilitation dominates. It not known whether this early life loop. We hypothesized newborn functions independently sensory input, before maturation control. show here noxious hind paw pinch evokes no...
Descending connections from brainstem nuclei are known to exert powerful control of spinal nociception and pain behaviours in adult mammals. Here we present evidence that descending serotonergic fibres not only inhibit nociceptive activity, but also facilitate non-noxious tactile activity the healthy rat dorsal horn via activation 5-HT3 receptors (5-HT3Rs). We further show this differential emerges a non-modality selective system young rats. Serotonergic background 5-HT3R mediated...
Abstract Touch sensation is primarily encoded by mechanoreceptors, called Low-Threshold Mechanoreceptors (LTMRs), with their cell bodies in the Dorsal Root Ganglia (DRG). Because of great diversity terms molecular signature, terminal endings morphology and electrophysiological properties, mirroring complexity tactile experience, LTMRs are a model choice to study cues differentially controlling neuronal diversification. While transcriptional codes that define different LTMR subtypes have been...
Abstract PIEZO2 mechanosensitive channels are required for normal touch sensation. However, almost completely blocked at negative resting membrane potentials. We show that voltage-block can be relieved by mutations a conserved Arginine (R2756) which dramatically sensitizes the channel to mechanical stimuli. generated Piezo2 R2756H/R2756H and R2756K/R2756K knock-in mice ask how voltage regulates endogenous mechanosensitivity of sensory neurons. Surprisingly, currents in nociceptors, neurons...
Touch sensation is primarily encoded by mechanoreceptors, called Low-Threshold Mechanoreceptors (LTMRs), with their cell bodies in the Dorsal Root Ganglia (DRG). Because of great diversity terms molecular signature, terminal endings morphology and electrophysiological properties, mirroring complexity tactile experience, LTMRs are a model choice to study cues differentially controlling neuronal diversification. While transcriptional codes that define different LTMR subtypes have been...
Fingertip mechanoreceptors comprise sensory neuron endings together with specialized skin cells that form the end-organ. Exquisitely sensitive vibration-sensing neurons are associated Meissner’s corpuscles and Pacinian 1 . Such end-organ structures have been recognized for more than 160 years, but their exact functions remained a matter of speculation. Here we examined role USH2A in touch sensation humans mice. The gene encodes transmembrane protein very large extracellular domain....
Touch sensation is primarily encoded by mechanoreceptors, called Low-Threshold Mechanoreceptors (LTMRs), with their cell bodies in the Dorsal Root Ganglia. Because of great diversity terms molecular signature, terminal endings morphology and electrophysiological properties, mirroring complexity tactile experience, LTMRs are a model choice to study cues differentially controlling neuronal diversification. While transcriptional codes that define different LTMR subtypes have been extensively...