A5050041136- Amino Acid Enzymes and Metabolism
- Neuroscience and Neuropharmacology Research
- Biomedical Research and Pathophysiology
- Neuroinflammation and Neurodegeneration Mechanisms
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Drug Transport and Resistance Mechanisms
- Cancer, Stress, Anesthesia, and Immune Response
- Effects of Radiation Exposure
- Diabetes Treatment and Management
- Pancreatic function and diabetes
- Receptor Mechanisms and Signaling
- Immune Response and Inflammation
- Epilepsy research and treatment
- Neurogenesis and neuroplasticity mechanisms
- Tryptophan and brain disorders
- Renal Transplantation Outcomes and Treatments
Vrije Universiteit Brussel
2020-2024
Geneeskundige en Gezondheidsdienst
2019
Pharmac
2019
Abstract The astrocytic cystine/glutamate antiporter system x c − represents an important source of extracellular glutamate in the central nervous system, with potential impact on excitatory neurotransmission. Yet, its function and importance brain physiology remain incompletely understood. Employing slice electrophysiology mice a genetic deletion specific subunit , xCT (xCT −/− mice), we uncovered decreased neurotransmission at corticostriatal synapses. This effect was partly mitigated by...
Abstract The cystine/glutamate antiporter system x c − has been identified as the major source of extracellular glutamate in several brain regions well a modulator neuroinflammation, and genetic deletion its specific subunit xCT (xCT −/− ) is protective mouse models for age-related neurological disorders. However, previously observed oxidative shift plasma cystine/cysteine ratio adult mice led to hypothesis that would negatively affect life- healthspan. Still, till now role physiological...
xCT (Slc7a11), the specific subunit of cystine/glutamate antiporter system x
Despite ample evidence for the therapeutic potential of inhibition cystine/glutamate antiporter system x c − in neurological disorders and cancer, none proposed inhibitors is selective. In this context, a lot research has been performed using EMA- FDA-approved drug sulfasalazine (SAS). Even though molecule already on market decades as an anti-inflammatory drug, serious side effects due to its use have reported. Whereas treatment main indications, SAS needs be cleaved intestine into compound...
The astrocytic cystine/glutamate antiporter system x c - (with xCT as the specific subunit) imports cystine in exchange for glutamate and has been shown to interact with multiple pathways brain that are dysregulated age-related neurological disorders, including homeostasis, redox balance, neuroinflammation. In current study, we investigated effect of genetic deletion on lactacystin (LAC)- 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced degeneration nigrostriatal pathway, models...
Purpose Total body irradiation (TBI) followed by bone marrow transplantation (BMT) is used in pre-clinical research to generate mouse chimeras that allow study the function of a protein specifically on immune cells. Adverse consequences juvenile and brain are well described include general fatigue, neuroinflammation, neurodegeneration cognitive impairment. Yet, long-term TBI/BMT performed healthy adult mice have been poorly investigated.
Event Abstract Back to The cystine/glutamate antiporter system xc- as modulator of corticostriatal neurotransmission Olaya Lara1*, Eduard Bentea1, Agnes Villers2, Cynthia Moore3, Adam Funk4, Sinead O'Donovan4, Lise Verbruggen1, Laura De Pauw1, Erica Depasquale5, Madeline Churchill3, Hideyo Sato6, Laurence Ris2, Charles K. Meshul7, Robert McCullumsmith4 and Ann Massie1 1 Vrije University Brussel, Belgium 2 Mons, 3 Portland VA Research Foundation, United States 4 Toledo, 5 Cincinnati, 6...