A5017389205- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Amino Acid Enzymes and Metabolism
- Stress Responses and Cortisol
- Ubiquitin and proteasome pathways
- Alzheimer's disease research and treatments
- Nuclear Receptors and Signaling
- Neurogenesis and neuroplasticity mechanisms
- Multiple Sclerosis Research Studies
- Parkinson's Disease Mechanisms and Treatments
- Epilepsy research and treatment
- Biomedical Research and Pathophysiology
- Neurological disorders and treatments
- Neurological Disease Mechanisms and Treatments
- Memory and Neural Mechanisms
- Neuroendocrine regulation and behavior
- Immunotherapy and Immune Responses
- Histone Deacetylase Inhibitors Research
- RNA regulation and disease
- Retinoids in leukemia and cellular processes
- Botulinum Toxin and Related Neurological Disorders
- Ion channel regulation and function
- Photoreceptor and optogenetics research
- Viral Infections and Immunology Research
VIB-KU Leuven Center for Brain & Disease Research
2024
KU Leuven
2024
Vlaams Instituut voor Biotechnologie
2024
Institut du Fer à Moulin
2019-2023
Inserm
2019-2023
Sorbonne Université
2020-2023
NYU Langone Health
2023
Vrije Universiteit Brussel
2015-2021
Pharmac
2015-2018
University of Pavia
2016
Astrocytes are active players in higher brain function as they can release gliotransmitters, which essential for synaptic plasticity. Various mechanisms have been proposed gliotransmission, including vesicular well non-vesicular ones, example by passive diffusion via connexin hemichannels (HCs). We here investigated whether interfering with connexin43 (Cx43) HCs influenced hippocampal spatial memory. made use of the peptide Gap19 that blocks but not gap junction channels and is specific...
Abstract Accumulating evidence shows a key function for astrocytic connexin43 (Cx43) signaling in epilepsy. However, the lack of experimental distinction between Cx43 gap junction channels (GJCs) and hemichannels (HCs) has impeded identification exact contribution either channel configurations to We therefore investigated whether TAT‐Gap19, Cx mimetic peptide that inhibits HCs but not corresponding GJCs, influences experimentally induced seizures rodents. Dye uptake experiments acute...
Abstract The role of microglia in the amyloid cascade Alzheimer’s disease (AD) is debated due to conflicting findings. Using a genetic and pharmacological approach we demonstrate that depletion before amyloid-β (Aβ) plaque deposition, leads reduction numbers neuritic dystrophy, confirming their initiation. Transplanting human restores Aβ formation. While reduces insoluble levels, soluble concentrations stay consistent, challenging view clear Aβ. In later stages, microglial decreases...
Parkinson's disease is a neurodegenerative disorder characterized by motor and non-motor disturbances. Various pathogenic pathways drive progression including oxidative stress, mitochondrial dysfunction, α-synuclein aggregation impairment of protein degradation systems. Dysfunction the ubiquitin-proteasome system in substantia nigra patients believed to be one causes cell death associated with this disorder. Lactacystin, potent inhibitor proteasome, was previously delivered nigrostriatal...
ABSTRACT The cystine/glutamate antiporter or system exchanges cystine for glutamate, thereby supporting intracellular glutathione synthesis and nonvesicular glutamate release. role of in neurological disorders can be dual remains a matter debate. One important reason the contradictory findings that have been reported to date is use nonspecific anti‐xCT (the specific subunit ) antibodies. Often studies rely on predicted molecular weight 55.5 kDa identify xCT Western blots. However, using...
Abstract The communication between the immune and central nervous system (CNS) is affected in many neurological disorders. Peripheral injections of endotoxin lipopolysaccharide (LPS) are widely used to study this communication: an LPS challenge leads a biphasic syndrome that starts with acute sickness followed by persistent brain inflammation chronic behavioral alterations such as depressive‐like symptoms. In vitro , response treatment has been shown involve enhanced expression . This...
Multiple sclerosis (MS) is an autoimmune demyelinating disease that affects the central nervous system (CNS), leading to neurodegeneration and chronic disability. Accumulating evidence points a key role for neuroinflammation, oxidative stress, excitotoxicity in this degenerative process. System xc − or cystine/glutamate antiporter could tie these pathological mechanisms together: its activity enhanced by reactive oxygen species inflammatory stimuli, enhancement might lead release of toxic...
Summary Objective Besides seizures, patients with epilepsy are affected by a variety of cognitive and psychiatric comorbidities that further impair their quality life. The present study provides an in‐depth characterization the behavioral alterations induced 6 Hz corneal kindling. Furthermore, we correlate these changes to in c‐Fos protein expression throughout brain following Methods Adolescent male Naval Medical Research Institute ( NMRI ) mice were kindled via repetitive subconvulsive...
Abstract Objective The cystine/glutamate antiporter system could represent a new target for antiepileptogenic treatments due to its crucial roles in glutamate homeostasis and neuroinflammation. To demonstrate this, we compared epilepsy development seizure susceptibility xCT knockout mice ( −/− ) littermate controls +/+ different chronic models of epilepsy. Methods Mice were surgically implanted with electrodes the basolateral amygdala chronically stimulated develop self‐sustained status...
<title>Abstract</title> Monoclonal antibodies Aducanumab, Lecanemab, Gantenerumab, and Donanemab have been developed for treatment of Alzheimer’s disease. Here, we used single-molecule detection techniques super-resolution imaging to characterise the binding these beta-amyloid aggregates including human post-mortem brain samples. Lecanemab is best antibody in terms small-soluble aggregates, affinity, aggregate coating, ability bind post-translationally modified species, explaining its...
Parkinson's disease (PD) is a neurodegenerative disorder, characterized by loss of dopamine (DA) neurons in the substantia nigra pars compacta (SNc). Caloric restriction (CR) has been shown to exert ghrelin-dependent neuroprotective effects 1-methyl-4-phenyl-1,2,3,6-tetrathydropyridine (MPTP)-based animal model for PD. We here investigated whether CR lactacystin (LAC) mouse PD, which proteasome disruption leads destruction DA SNc, and this effect mediated via ghrelin receptor. Adult male...
Objectives: The cystine/glutamate antiporter (system xc-) is believed to contribute nonvesicular glutamate release from glial cells in various brain areas. Although recent investigations implicate system xc- mood disorders, unambiguous evidence has not yet been established. Therefore, we evaluated the possible role of depressive state. Methods: We conducted a protein expression analysis specific subunit (xCT) regions corticosterone mouse model, Flinders Sensitive Line rat model and...
The astrocytic cystine/glutamate antiporter system x c - (with xCT as the specific subunit) imports cystine in exchange for glutamate and has been shown to interact with multiple pathways brain that are dysregulated age-related neurological disorders, including homeostasis, redox balance, neuroinflammation. In current study, we investigated effect of genetic deletion on lactacystin (LAC)- 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced degeneration nigrostriatal pathway, models...