A5016612071- Neuroinflammation and Neurodegeneration Mechanisms
- Receptor Mechanisms and Signaling
- Tryptophan and brain disorders
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- T-cell and B-cell Immunology
- Nicotinic Acetylcholine Receptors Study
- Neurogenesis and neuroplasticity mechanisms
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Neurological Disease Mechanisms and Treatments
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Cell Adhesion Molecules Research
- Signaling Pathways in Disease
- Pharmacological Receptor Mechanisms and Effects
- Nuclear Receptors and Signaling
- Neuropeptides and Animal Physiology
- Phosphodiesterase function and regulation
- Monoclonal and Polyclonal Antibodies Research
- Stress Responses and Cortisol
- Memory and Neural Mechanisms
- Cerebrovascular and genetic disorders
- S100 Proteins and Annexins
- Spinal Cord Injury Research
Institut du Fer à Moulin
2012-2023
Inserm
2012-2023
Sorbonne Université
2011-2023
NYU Langone Health
2023
Université Sorbonne Nouvelle
2019-2020
Institut de Biologie de l'École Normale Supérieure
2004-2008
École Normale Supérieure - PSL
2006
Institut Pasteur
1999-2003
Centre National de la Recherche Scientifique
1999-2001
Universidad Complutense de Madrid
1998
In several brain regions, microglia actively promote neuronal apoptosis during development. However, molecular actors leading to trigger death remain mostly unknown. Here, we show that, in the developing hippocampus, apoptotic neurons are contacted by expressing both integrin CD11b and immunoreceptor DAP12. We demonstrate that developmental decreases mice deficient for or addition, function-blocking antibodies directed against decrease when injected into wild-type neonates, but have no...
Several proteins are expressed in both immune and nervous systems. However, their putative nonimmune functions the brain remain poorly understood. KARAP/DAP12 is a transmembrane polypeptide associated with cell-surface receptors hematopoeitic cells. Its mutation humans induces Nasu-Hakola disease, characterized by presenile dementia demyelinization. alteration of white matter occurs months after onset neuropsychiatric symptoms, suggesting that other neuronal alterations occur early phases...
Maturation of functional neuronal circuits during central nervous system development relies on sophisticated mechanisms. First, axonal and dendritic growth should reach appropriate targets for correct synapse elaboration. Second, pruning death are required to eliminate redundant or inappropriate connections. Serotonin, in addition its role as a neurotransmitter, actively participates postnatal establishment refinement brain wiring mammals. Brain resident macrophages, that is, microglia, also...
Epidemiological studies have linked maternal infection during pregnancy to later development of neuropsychiatric disorders in the offspring. In mice, experimental inflammation embryonic impairs behavioral and cognitive performances adulthood. Synaptic dysfunctions may be at origin impairments, however link between prenatal synaptic defects remains established.In this study, we show that alteration microglial function, including inflammation, induces delayed dysfunction adult. DAP12 is a...
Abstract The mechanism through which CD28 costimulation potentiates TCR-driven gene expression is still not clearly defined. Vav-1, an exchange factor for Rho GTPases thought to regulate, mainly Rac-1, various signaling components leading cytokine expression, tyrosine phosphorylated upon engagement. Here, we provide evidence a key role of Vav-1 in CD28-mediated signaling. Overexpression Jurkat cells combination with ligation strongly reduced the concentration staphylococcus enterotoxin E/MHC...
Abstract Severe peripheral infections induce an adaptive sickness behavior and innate immune reaction in various organs including the brain. On long term, persistent alteration of microglia, brain cells, is associated with increased risk psychiatric disorders. It thus critical to identify genes mechanisms controlling intensity duration neuroinflammation induced by challenges. We tested hypothesis that 5‐HT 2B receptor, main serotonin receptor expressed might represent a valuable candidate ....
Retroviral genomes consist of two identical RNA molecules joined noncovalently near their 5'-ends. Recently, models have been proposed for dimer formation on the basis results obtained in vitro with human immunodeficiency virus type 1 and Moloney murine leukemia RNA. It was first that viral dimerizes by forming an interstrand quadruple helix purine tetrads. The second model postulates dimerization is initiated a loop−loop interaction between molecules. In order to better characterize process...
Vezatin is an integral membrane protein associated with cell-cell adhesion complex and actin cytoskeleton. It expressed in the developing mature mammalian brain, but its neuronal function unknown. Here, we show that localizes spines mouse hippocampal neurons codistributes PSD95, a major scaffolding of excitatory postsynaptic density. Forebrain-specific conditional ablation <i>Vezatin</i> induced anxiety-like behavior impaired cued fear-conditioning memory response. knock-down cultured...
Microglial cells are resident innate immune of the brain that constantly scan their environment with long processes and, upon disruption homeostasis, undergo rapid morphological changes. For example, a laser lesion induces in few minutes an oriented growth microglial processes, also called "directional motility", toward site injury. A similar effect can be obtained by delivering locally ATP or serotonin (5-hydroxytryptamine [5-HT]). In this article, we describe protocol to induce directional...
We have previously shown that a tyrosine to leucine replacement in the transmembrane region of T cell receptor (TCR)-β results deficient induction CD95-L and apoptosis upon TCR triggering transfected line. By contrast, interleukin (IL)-2 production expression CD25 CD69 were normally induced. Since mutation TCR-β also resulted impaired association CD3-ζ, it was proposed this chain is specifically required for apoptosis. now show does not derive from general lower second messengers, since...
Abstract Approximately 15 million babies are born prematurely every year and many will face lifetime motor and/or cognitive deficits. Children at higher risk of developing perinatal brain lesions, especially white matter injuries (WMI). Evidence in humans rodents demonstrates that systemic inflammation-induced neuroinflammation, including microglial astrocyte reactivity, is the prominent processes WMI associated with preterm birth. Thus, a new challenge field to develop neuroprotective...
Abstract The proper maturation of emotional and sensory circuits requires a fine tuning serotonin (5-HT) level during early postnatal development. Consistently, dysfunctions the serotonergic system have been associated with neurodevelopmental psychiatric diseases, including autism spectrum disorders (ASD). However, mechanisms underlying developmental effects 5-HT remain partially unknown, one obstacle being action on different cell types. Here, we focused microglia, which play role in brain...
Microglial cells are resident innate immune of the brain that constantly scan their environment with long processes and, upon disruption homeostasis, undergo rapid morphological changes. For example, a laser lesion induces in few minutes an oriented growth microglial processes, also called "directional motility", toward site injury. A similar effect can be obtained by delivering locally ATP or serotonin (5-hydroxytryptamine [5-HT]). In this article, we describe protocol to induce directional...