A5088032672- Osteoarthritis Treatment and Mechanisms
- Acute Ischemic Stroke Management
- Bone health and osteoporosis research
- Cellular Mechanics and Interactions
- Tendon Structure and Treatment
- Mesenchymal stem cell research
- Bone and Joint Diseases
- Knee injuries and reconstruction techniques
- Plant Molecular Biology Research
- Cerebrovascular and Carotid Artery Diseases
- Plant Reproductive Biology
- Stroke Rehabilitation and Recovery
- Proteoglycans and glycosaminoglycans research
- Plant tissue culture and regeneration
- Tissue Engineering and Regenerative Medicine
- Hydrogels: synthesis, properties, applications
- Bone Metabolism and Diseases
- Periodontal Regeneration and Treatments
- Plant nutrient uptake and metabolism
- Lung Cancer Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Thermoregulation and physiological responses
- Adipokines, Inflammation, and Metabolic Diseases
- Fibroblast Growth Factor Research
- Blood properties and coagulation
North Carolina State University
2016-2025
University of Minnesota
2021-2022
Trinity College Dublin
2011-2016
University of Notre Dame
2011-2016
University of the Witwatersrand
1999
Seedling emergence is critical for food security. It requires rapid hypocotyl elongation and apical hook formation, both of which are mediated by regulated cell expansion. How these events coordinated in etiolated seedlings unclear. Here, we show that biphasic control expansion the phytohormone auxin underlies this process. Shortly after germination, high levels restrain elongation. This provides a temporal window involving gravity-induced maximum on eventual concave side hook. induces...
Stroke patients lose bone mass and experience fracture at an elevated rate. Although functional intraosseous vasculature is necessary for skeletal maintenance, the effect of stroke on osteovasculature unknown. In this study we characterized changes to osteovascular perfusion, structure, composition following mild-to-moderate severity in mice, both with without exercise therapy. Twelve-week-old male mice (n = 27) received either ischemic (middle cerebral artery occlusion) or sham procedure,...
Cartilage tissue engineering is a growing field due to the lack of regenerative capacity native tissue. The use bioreactors for cartilage common, but results are controversial. Some studies suggest that microgravity ideal chondrogenesis, while others show mimicking hydrostatic pressure crucial formation. A parallel study comparing effects loading and unloading on chondrogenesis has not been performed.The goal this was evaluate human adipose-derived stem cells (hASC) under two different...
Development and maintenance of a vascular network are critical for bone growth homeostasis; strategies that promote function clinical success tissue-engineered constructs. Co-culture endothelial cells (ECs) with mesenchymal stem (MSCs) exposure to 10% cyclic tensile strain have both been shown regulate osteogenesis in isolation, but potential synergistic effects yet be explored. The objective this study was expose an MSC-EC co-culture examine the role mechanical stimulus on behavior. We...
Although hydrostatic pressure (HP) is known to regulate chondrogenic differentiation of mesenchymal stromal/stem cells (MSCs), improved insight into the mechanotransduction HP may form basis for novel tissue engineering strategies. Previously, we demonstrated that matrix stiffness and calcium ion (Ca(++)) mobility HP; however, mechanisms, by which these Ca(++) signaling pathways are initiated, currently unknown. The purinergic pathway, in adenosine triphosphate (ATP) released activates...
Ischemic stroke induces rapid loss in bone mineral density that is up to 13 times greater than during normal aging, leading a markedly increased risk of fracture. Little known about skeletal changes following beyond loss. In this study, we use mild-moderate middle cerebral artery occlusion model determine the effects ischemic without bedrest on microstructure, dynamic formation, and tissue composition. Twenty-seven 12-week-old male C57Bl/6J mice received either or sham surgery then daily...
Abstract Rationale Stroke patients lose bone mass and experience fracture at an elevated rate. Although functional intraosseous vasculature is necessary for skeletal maintenance, the effect of stroke on osteovasculature unknown. Objective To characterize changes to osteovascular function, structure, composition following mild-to-moderate-severity ischemic in mice, both with without exercise therapy. Methods Results Twelve-week-old male mice (n=27) received either a (middle cerebral artery...
A purposeful sample of Black Sowetan residents who had sustained a stroke were studied to identify the problems they encountering after discharge back their homes. descriptive qualitative approach was used comprising semi-structured interviews in subjects’ Audio recorded data transcribed extenso, and coded into themes. The revealed that lacked knowledge disease processes. However, medication non-complianc largely due financial transportation difficulties attending clinics. Although most able...
ABSTRACT Ischemic stroke induces rapid loss in bone mineral density that is up to 13 times greater than during normal aging, leading a markedly increased risk of fracture. Little known about skeletal changes following beyond loss. In this study we use mild-moderate middle cerebral artery occlusion model determine the effects ischemic without bedrest on microstructure, dynamic formation, and tissue composition. Twenty-seven 12-week-old male C57Bl/6J mice received either or sham surgery then...
Abstract Although body mass index is positively associated with bone mineral density, suggesting obesity protective against fracture, elderly obese individuals experience greater fracture risk at certain sites than non-obese peers, structural or material changes contribute to fragility. Diet-induced rodent studies have reported detrimental microstructure and some apparent-level properties, but tissue-level are not well understood. Because adipose tissue highly vascularized, remodeling...
Abstract Seedling emergence is critical for food security. It requires rapid hypocotyl elongation and apical hook formation, both of which are mediated by regulated cell expansion. How these events coordinated in etiolated seedlings unclear. Here, we show that biphasic control expansion the phytohormone auxin underlies this process. Shortly after germination, high levels restrain elongation. This provides a temporal window involving gravity-induced maximum on eventual concave side hook,...
Fluid pressurization is the dominant load-bearing mechanism of in vivo joint environment, supporting up to 90% compressive loads cartilage[1]. In accordance with its prominence cartilaginous tissues, hydrostatic pressure (HP) significantly enhances chondrogenic differentiation mesenchymal stem cells (MSCs) [2,3]. However, surprisingly little known about mechanisms by which sense HP and translate it into a biochemical signal. This partly due fact that generates state stress deformation, as...