A5078299864- Nanoplatforms for cancer theranostics
- Colorectal Cancer Surgical Treatments
- Cancer Research and Treatments
- Lung Cancer Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Gastric Cancer Management and Outcomes
- Cardiac, Anesthesia and Surgical Outcomes
- Esophageal Cancer Research and Treatment
- Reconstructive Surgery and Microvascular Techniques
- Photodynamic Therapy Research Studies
- Cancer, Hypoxia, and Metabolism
- Neuroendocrine Tumor Research Advances
- Breast Cancer Treatment Studies
- Optical Imaging and Spectroscopy Techniques
- Breast Implant and Reconstruction
- Anorectal Disease Treatments and Outcomes
- Esophageal and GI Pathology
- Surgical site infection prevention
- Pancreatic and Hepatic Oncology Research
- Photoacoustic and Ultrasonic Imaging
- Bone fractures and treatments
- Surgical Simulation and Training
- Endometrial and Cervical Cancer Treatments
- Lymphatic System and Diseases
- Lung Cancer Research Studies
Radboud University Nijmegen
2024
Radboud University Medical Center
2024
University Medical Center
2024
Erasmus MC Cancer Institute
2024
The Netherlands Cancer Institute
2022-2024
Leiden University
2012-2023
Leiden University Medical Center
2007-2023
Emory University
2013
Beth Israel Deaconess Medical Center
2009-2012
Hokkaido University
2012
BACKGROUND The fundamental principle of oncologic surgery is the complete resection malignant cells. However, small tumors are often difficult to find during using conventional techniques. objectives this study were determine if optical imaging, a contrast agent already approved for other indications, could improve hepatic metastasectomy with curative intent, optimize dose and timing, mechanism accumulation. METHODS high tissue penetration near‐infrared (NIR) light was exploited by use FLARE...
Near-infrared (NIR) fluorescent sentinel lymph node (SLN) mapping in breast cancer requires optimized imaging systems and lymphatic tracers.A small, portable version of the FLARE system, termed Mini-FLARE, was developed for capturing color video two semi-independent channels NIR fluorescence (700 800 nm) real time. Initial optimization tracer dose performed using 35-kg Yorkshire pigs a 6-patient pilot clinical trial. More refined 24 consecutive patients. All patients received standard care...
Near-infrared (NIR) fluorescence imaging using indocyanine green (ICG) has the potential to improve sentinel lymph node (SLN) mapping of breast cancer. We performed a randomized clinical trial assess value blue dyes when used in combination with NIR fluorescence. also preliminarily examined possibility performing SLN without radiotracers.Clinical subjects were 24 consecutive cancer patients scheduled undergo biopsy. All received standard care 99(m) technetium-nanocolloid and 1.6 mL 500 μM...
Background: The ability to determine flap perfusion in reconstructive surgery is still primarily based on clinical examination. In this study, the authors demonstrate use of an intraoperative, near-infrared fluorescence imaging system for evaluation perforator location and perfusion. Methods: Indocyanine green was injected intravenously six breast cancer patients undergoing a deep inferior epigastric reconstruction after mastectomy. Three dose levels indocyanine were assessed using...
Despite recent advances in perforator flap reconstruction, there can be significant variability vessel size and location. Although preoperative evaluation may provide valuable information, real-time intraoperative methods have the potential to greatest benefit. Our laboratory has developed Fluorescence-Assisted Resection Exploration (FLARE™) near-infrared (NIR) fluorescence imaging system for visualization of details underlying vasculature. The FLARE™ uses indocyanine green, a safe reliable...
Regional lymph node involvement is the most important prognostic factor in cutaneous melanoma. As only 20% of patients with melanoma have occult nodal disease and would benefit from a regional lymphadenectomy, sentinel (SLN) biopsy was introduced. Near-infrared (NIR) fluorescence has been hypothesized to improve SLN mapping. To assess potential intraoperative NIR imaging mapping examine optimal dose indocyanine green adsorbed human serum albumin (ICG:HSA). Fifteen consecutive underwent...
<i>Background:</i> Intraoperative visualization of pancreatic tumors has the potential to improve radical resection rates. common bile duct and anastomoses could be added value. In this study, we explored use indocyanine green (ICG) for these applications attempted optimize injection timing dose. <i>Methods:</i> Eight patients undergoing a pancreaticoduodenectomy were injected intravenously with 5 or 10 mg ICG. During after injection, pancreas, tumor, surrounding...
Intraoperative identification of parathyroid adenomas can be challenging. We hypothesized that low-doses methylene blue (MB) and near-infrared fluorescence (NIRF) imaging could used to identify intraoperatively.MB was injected intravenously after exploration at a dose 0.5 mg/kg into 12 patients who underwent surgery. NIRF performed using the Mini-FLARE system.In 10 patients, histology confirmed adenoma. In 9 these clearly adenoma during Seven had positive preoperative (99m) Tc-sestamibi...
Abstract Background Indocyanine green near-infrared fluorescence bowel perfusion assessment has shown its potential benefit in preventing anastomotic leakage. However, the surgeon's subjective visual interpretation of signal limits validity and reproducibility technique. Therefore, this study aimed to identify objective quantified patterns patients undergoing colorectal surgery using a standardized imaging protocol. Method A video was recorded. Postoperatively, videos were by drawing...
<h3>Objective:</h3> In early cervical cancer, a total pelvic lymphadenectomy is the standard of care, even though most patients have negative nodes and thus undergo unnecessarily. Although value sentinel lymph node (SLN) mapping in early-stage cancer has not yet been established, near-infrared (NIR) fluorescence imaging promising technique to perform this procedure. Near-infrared based on invisible NIR light can provide high sensitivity, high-resolution, real-time image guidance during...
Sentinel lymph node (SLN) mapping in colorectal cancer may have prognostic and therapeutic significance; however, currently available techniques are not optimal. We hypothesized that the combination of invisible near-infrared (NIR) fluorescent light ex vivo injection could solve remaining problems SLN cancer.The FLARE imaging system was used for real-time identification SLNs after NIR lymphatic tracer HSA800 colon rectum (n = 4) pigs. A total 32 mappings were performed oncologic resection...