A5021939051- Pancreatic and Hepatic Oncology Research
- Gallbladder and Bile Duct Disorders
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Surgical Treatments
- Pancreatitis Pathology and Treatment
- Neurogenetic and Muscular Disorders Research
- Esophageal and GI Pathology
- Surgical site infection prevention
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Infectious Diseases and Tuberculosis
- Pleural and Pulmonary Diseases
- Mycobacterium research and diagnosis
- Whipple's Disease and Interleukins
- History of Medical Practice
- Anorectal Disease Treatments and Outcomes
- Economic and Financial Impacts of Cancer
- Cardiac, Anesthesia and Surgical Outcomes
Leiden University
2023-2025
Leiden University Medical Center
2020-2024
Previous studies have reported conflicting results of prolonged antibiotic prophylaxis on infectious complications after pancreatoduodenectomy. This study evaluated the effect antibiotics surgical-site infections (SSIs) pancreatoduodenectomy.A systematic review and meta-analysis was undertaken SSIs in patients with perioperative (within 24 h) versus (over were classified as organ/space or superficial SSI within 30 days surgery. ORs calculated using a Mantel-Haenszel fixed-effect model.Ten...
Consensus and evidence on the impact of pre-emptive antibiotic treatment after pancreatoduodenectomy is lacking, which reflected by contradictory recommendations in (inter)national guidelines current clinical practice. Pre-emptive may reduce risk abdominal surgical site infections patients with a high contaminated bile undergoing pancreatoduodenectomy. This pertains mostly preoperative biliary drainage or an ampullary malignancy. The SPARROW trial will evaluate effect malignancy multicentre,...
Abdominal infections account for substantial morbidity after pancreatoduodenectomy. Contaminated bile is the presumed main risk factor, and prolonged antibiotic prophylaxis might prevent these complications. This study compared organ/space infection (OSIs) rates in patients receiving perioperative versus pancreatoduodenectomy.Patients undergoing pancreatoduodenectomy two Dutch centers between 2016 2019 were included. Perioperative was (cefuroxime metronidazole five days). The primary outcome...