A5026972917- Colorectal Cancer Surgical Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Optical Imaging and Spectroscopy Techniques
- Nanoplatforms for cancer theranostics
- Surgical Simulation and Training
- Anorectal Disease Treatments and Outcomes
- Radiomics and Machine Learning in Medical Imaging
- Augmented Reality Applications
- Hepatocellular Carcinoma Treatment and Prognosis
- Photoacoustic and Ultrasonic Imaging
- Peripheral Artery Disease Management
- Advanced Radiotherapy Techniques
- Cancer Research and Treatments
- Anatomy and Medical Technology
Leiden University Medical Center
2022-2025
Abstract Background Indocyanine green near-infrared fluorescence bowel perfusion assessment has shown its potential benefit in preventing anastomotic leakage. However, the surgeon's subjective visual interpretation of signal limits validity and reproducibility technique. Therefore, this study aimed to identify objective quantified patterns patients undergoing colorectal surgery using a standardized imaging protocol. Method A video was recorded. Postoperatively, videos were by drawing...
Anastomotic leakage (AL) is one of the major complications after colorectal surgery. Compromised tissue perfusion at anastomosis site increases risk AL. Several cohort studies have shown that indocyanine green (ICG) combined with fluorescent near-infrared imaging a feasible and reproducible technique for real-time intraoperative perfusion, leading to reduced rates resection. Unfortunately, these were not randomised. Therefore, we propose randomised controlled trial assess value ICG-guided...
Abstract Purpose Assessment of tissue perfusion using near-infrared fluorescence (NIR) with indocyanine green (ICG) is gaining popularity, however reliable and objective interpretation remains a challenge. Therefore, this study aimed to establish reference curves for vital across target tissues imaging modality. Methods Data from five prospective cohorts conducted in three Dutch academic medical centres between December 2018 June 2023 was included. Quantitative analysis time-intensity...
SignificanceNear-infrared fluorescence imaging still lacks a standardized, objective method to evaluate fluorescent dye efficacy in oncological surgical applications. This results difficulties translation between preclinical clinical studies with dyes and the reproduction of studies, which turn hampers further novel dyes.AimOur aim is develop semi-automatic standardized objectively assess signals resected tissue.ApproachA procedure was designed quantitative analysis methods were developed...
Background: Robotic liver surgery represents the most recent evolution in field of minimally-invasive surgery. For planning and guidance resections, surgeons currently rely on preoperative 2-dimensional (2D) CT and/or MR imaging intraoperative ultrasonography. Translating 2D images into digital 3-dimensional (3D) models may improve both surgical guidance. The da Vinci® robotic system is a platform suitable for integration multiple modalities one single view. In this study, we describe...
Fluorescence-guided surgery (FGS) has emerged as an innovative technique with promising applications in various surgical specialties. However, clinical implementation is hampered by limited availability of evidence-based reference work supporting the translation towards standard-of-care use practice. Therefore, we developed a consensus statement on current FGS.
Abstract Purpose Metastasectomy is a common treatment option for patients with colorectal lung metastases (CLM). Challenges exist margin assessment and identification of small nodules, especially during minimally invasive surgery. Intraoperative fluorescence imaging has the potential to overcome these challenges. The aim this study was assess feasibility targeting CLM carcinoembryonic antigen (CEA) specific fluorescent tracer SGM-101. Methods This prospective, open-label study. primary...
<title>Abstract</title> Purpose Assessment of tissue perfusion using near-infrared fluorescence (NIR) with indocyanine green (ICG) is gaining popularity, however reliable and objective interpretation remains a challenge. Therefore, this study aimed to establish reference curves for vital multiple target tissues imaging modality. Methods Data from five prospective cohorts conducted in three Dutch academic medical centres between December 2018 June 2023 was included. Quantitative analysis ICG...