A5075003000- Peripheral Artery Disease Management
- Cardiac, Anesthesia and Surgical Outcomes
- Parathyroid Disorders and Treatments
- Aortic aneurysm repair treatments
- Thyroid Cancer Diagnosis and Treatment
- Cerebrovascular and Carotid Artery Diseases
- Diabetic Foot Ulcer Assessment and Management
- Diagnosis and Treatment of Venous Diseases
- Cell Adhesion Molecules Research
- Thyroid and Parathyroid Surgery
- Aortic Disease and Treatment Approaches
- Vascular Procedures and Complications
- Atherosclerosis and Cardiovascular Diseases
- Coronary Interventions and Diagnostics
- Pituitary Gland Disorders and Treatments
- Blood Coagulation and Thrombosis Mechanisms
- Medical Imaging and Pathology Studies
- Cardiovascular Health and Disease Prevention
- Optical Imaging and Spectroscopy Techniques
- Genetic Syndromes and Imprinting
- Adrenal and Paraganglionic Tumors
- Angiogenesis and VEGF in Cancer
- Medical Education and Admissions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Complement system in diseases
Leiden University Medical Center
2016-2025
Leiden University
2006-2024
Dutch Institute for Clinical Auditing
2020
Society for Vascular Surgery
2020
Haga Hospital
2018-2020
Amsterdam University Medical Centers
2020
University of Amsterdam
2020
Hubrecht Institute for Developmental Biology and Stem Cell Research
2012
Amsterdam UMC Location Vrije Universiteit Amsterdam
2007
University of Colorado Health
2006
The Wnt signaling pathway was originally uncovered as one of the prototype developmental cascades in invertebrates well vertebrates. first indication that also plays a role adult animal came from study intestine Tcf-4 (Tcf7L2) knockout mice. gastrointestinal epithelium continuously self-renews over lifetime an organism and is, fact, most rapidly self-renewing tissue mammalian body. Recent studies indicate central biology stem cells. Furthermore, mutational activation cascade is principle...
Abstract Purpose We conducted a cost-effectiveness analysis in which we compared preoperative [ 18 F]Fluorocholine PET/CT-based one-stop-shop imaging strategy with current best practice PET/CT is only recommended after negative or inconclusive 99m Tc]Tc-methoxy isobutyl isonitrile SPECT/CT for patients suffering from primary hyperparathyroidism. investigated whether the performs as well but at lower costs. Methods developed cohort-level state transition model to evaluate both strategies...
The immune system is thought to play a crucial role in regulating collateral circulation (arteriogenesis), vital compensatory mechanism patients with arterial obstructive disease. Here, we studied the of lymphocytes murine model hindlimb ischemia.Lymphocytes, detected markers for NK1.1, CD3, and CD4, invaded vessel wall. Arteriogenesis was impaired C57BL/6 mice depleted Natural Killer (NK)-cells by anti-NK1.1 antibodies NK-cell-deficient transgenic mice. was, however, unaffected J...
Because late vein graft failure is caused by intimal hyperplasia (IH) and accelerated atherosclerosis, these processes are thought to be inflammation driven, influx of monocytes one the first phenomena seen in IH, we would like provide direct evidence for a role MCP-1 pathway development disease.MCP-1 expression demonstrated various stages disease murine model which venous interpositions placed carotid arteries hypercholesterolemic ApoE3Leiden mice cultured human saphenous (HSV) segments IH...
Abstract Background Postoperative ileus is a common complication of abdominal surgery, leading to patient discomfort, morbidity and prolonged postoperative length hospital stay (LOS). Previous studies suggested that chewing gum stimulates bowel function after but were underpowered evaluate its effect on LOS did not include enhanced recovery surgery (ERAS)-based perioperative care. This study evaluated whether elective reduces time in the setting ERAS-based Methods A multicentre RCT was...
Abstract Background Plaque angiogenesis is associated with atherosclerotic lesion growth, plaque instability and negative clinical outcome. a natural occurring process to fulfil the increasing demand of oxygen nourishment vessel wall. However, inadequate formed, immature neovessels are leaky cause intraplaque haemorrhage. Objective Blockade VEGFR 2 normalizes unbridled neovessel formation induces maturation nascent vessels resulting in prevention haemorrhage influx inflammatory cells into...
Genetic factors appear to be important in the restenotic process after percutaneous coronary intervention (PCI), as well inflammation, a pivotal factor restenosis. TNFalpha, key regulator of inflammatory responses, may exert critical influence on development restenosis PCI. The GENetic DEterminants Restenosis (GENDER) project included 3104 patients who underwent successful Systematic genotyping for six polymorphisms TNFalpha gene was performed. role also assessed ApoE*3-Leiden mice, knockout...
AimsFailure of vein graft conduits due to thickening, accelerated atherosclerosis, and subsequent plaque rupture is applicable 50% all grafts within 10 years. New potential therapeutic targets treat disease may be found in components the innate immune system, such as mast cells complement factors, which are known involved atherosclerosis destabilization. Interestingly, can activated by factor C5a and, therefore, a direct role for C5a-mediated cell activation anticipated. We hypothesize that...
Hypoparathyroidism is one of the most common complications after total or completion thyroidectomy. The reported incidence rate hypoparathyroidism in literature highly variable. Data that provide a better understanding magnitude this postoperative complication are warranted and can stepping stone for further collaborations aim to reduce rates establish uniform treatment protocols.To evaluate postoperative, persistent thyroidectomy patients who were referred university hospital centers assess...
Abstract Purpose Assessment of tissue perfusion using near-infrared fluorescence (NIR) with indocyanine green (ICG) is gaining popularity, however reliable and objective interpretation remains a challenge. Therefore, this study aimed to establish reference curves for vital across target tissues imaging modality. Methods Data from five prospective cohorts conducted in three Dutch academic medical centres between December 2018 June 2023 was included. Quantitative analysis time-intensity...
<title>Abstract</title> Non-functional parathyroid carcinoma (NFPC) is an exceptionally rare malignancy, with ± 50 reported cases since the description of glands in late 19<sup>th</sup> century. Unlike functional carcinomas (PC), which present extreme hyperparathyroidism (HPT) and are monitored using calcium hormone (PTH) levels, monitoring patients non-functional only relies on imaging. In this study, we two novel primary NFPC, alongside a comprehensive review literature including detailed...
Traditional exploration of surgical professionals' personality traits focuses on general characteristics at the domain-level five-factor model. Personality has been related to clinically-relevant areas such as clinical decision-making and team effectiveness, yet there is limited insight in surgeons facet-level Big Five. Here, we performed a large-scale study examining domain- facet-variations four generations subspecialties. The Five Inventory-2, measuring five domains fifteen corresponding...
Blok, Joris J. MD, PhD; Snijders, Heleen Huizing, Floortje MSc; Schmitz, Roderick F. Kerstjens, Lieke Sier, Vincent Q. Cathelijne C. MA; Lijkwan, Maarten A. Schepers, Abbey PhD Author Information
Restenosis is a negative effect of percutaneous coronary intervention (PCI). No clinical factors are available that allow good risk stratification. However, evidence exists genetic important in the restenotic process as well inflammation, pivotal factor restenosis. Association studies have identified genes may predispose to restenosis, but confirmation by large prospective lacking. Our aim was identify polymorphisms and haplotypes involved inflammatory pathways restenosis.The GENetic...
Tertiary hyperparathyroidism (tHPT), i.e., persistent HPT after kidney transplantation, affects 17–50% of transplant recipients. Treatment tHPT is mandatory since persistently elevated PTH concentrations KTx increase the risk renal allograft dysfunction and osteoporosis. The introduction cinacalcet in 2004 seemed to offer a medical treatment alternative parathyroidectomy (PTx). However, optimal management remains unclear. A retrospective analysis was performed on patients receiving...
Contemporary quality control methods are often insufficient in predicting clinical outcomes after revascularization lower extremity arterial disease (LEAD) patients. This study evaluates the potential of near-infrared fluorescence imaging with indocyanine green to predict outcome following revascularization. Near-infrared was performed before and within 5 days procedure. Clinical improvement defined as substantial pain free walking distance, reduction rest- and/or nocturnal pain, or tendency...
Background— Venous bypass grafts may fail because of development intimal hyperplasia and accelerated atherosclerosis. Inflammation plays a major role in these processes. Complement is an important part the immune system participates regulation inflammation. The exact complement process atherosclerosis vein has not yet been explored, however. Methods Results— To assess graft atherosclerosis, mouse model, which venous interposition was placed common carotid artery, used. In this thickening...